Preoperative Radiotherapy Improves Outcome in Recurrent Rectal Cancer
PURPOSE: METHODS: RESULTS:The median follow-up of patients alive for the total group was 16 (range, 4-156) months. Tumor characteristics were comparable between the two groups. Complete resections were performed in 64 percent of the patients who received preoperative radiation and 45 percent of the...
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| Veröffentlicht in: | Diseases of the colon & rectum 2005-05, Vol.48 (5), p.918-928 |
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| container_title | Diseases of the colon & rectum |
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| creator | Vermaas, Maarten Ferenschild, Floris T. J Nuyttens, Joost J. M. E Marinelli, Andreas W. K. S Wiggers, Theo van der Sijp, Joost R. M. M Verhoef, Cornelis Graveland, Wilfried J Eggermont, Alexander M. M de Wilt, Johannes H. W |
| description | PURPOSE:
METHODS:
RESULTS:The median follow-up of patients alive for the total group was 16 (range, 4-156) months. Tumor characteristics were comparable between the two groups. Complete resections were performed in 64 percent of the patients who received preoperative radiation and 45 percent of the nonirradiated patients. A complete response after radiotherapy was found in 10 percent of the preoperative irradiated patients (n = 6). There were no differences in morbidity and reintervention rate between the two groups. Local control after preoperative radiotherapy was statistically significantly higher after three and five years (P = 0.036). Overall survival and metastases-free survival were not different in both groups. Complete response to preoperative radiotherapy was predictive for an improved survival.
CONCLUSIONS: |
| doi_str_mv | 10.1007/s10350-004-0891-6 |
| format | Article |
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METHODS:
RESULTS:The median follow-up of patients alive for the total group was 16 (range, 4-156) months. Tumor characteristics were comparable between the two groups. Complete resections were performed in 64 percent of the patients who received preoperative radiation and 45 percent of the nonirradiated patients. A complete response after radiotherapy was found in 10 percent of the preoperative irradiated patients (n = 6). There were no differences in morbidity and reintervention rate between the two groups. Local control after preoperative radiotherapy was statistically significantly higher after three and five years (P = 0.036). Overall survival and metastases-free survival were not different in both groups. Complete response to preoperative radiotherapy was predictive for an improved survival.
CONCLUSIONS:</description><identifier>ISSN: 0012-3706</identifier><identifier>EISSN: 1530-0358</identifier><identifier>DOI: 10.1007/s10350-004-0891-6</identifier><identifier>PMID: 15785886</identifier><identifier>CODEN: DICRAG</identifier><language>eng</language><publisher>Secaucus, NJ: The ASCRS</publisher><subject>Aged ; Biological and medical sciences ; Combined Modality Therapy ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - radiotherapy ; Neoplasm Recurrence, Local - surgery ; Preoperative Care ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Radiotherapy Dosage ; Radiotherapy, Adjuvant ; Rectal Neoplasms - pathology ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Treatment Outcome ; Tumors</subject><ispartof>Diseases of the colon & rectum, 2005-05, Vol.48 (5), p.918-928</ispartof><rights>The ASCRS 2005</rights><rights>2005 INIST-CNRS</rights><rights>The American Society of Colon and Rectal Surgeons 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4674-1b8936a7efb02a42213566c81903740573e3b7745da60a34072e594bd58daa533</citedby><cites>FETCH-LOGICAL-c4674-1b8936a7efb02a42213566c81903740573e3b7745da60a34072e594bd58daa533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16864499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15785886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vermaas, Maarten</creatorcontrib><creatorcontrib>Ferenschild, Floris T. J</creatorcontrib><creatorcontrib>Nuyttens, Joost J. M. E</creatorcontrib><creatorcontrib>Marinelli, Andreas W. K. S</creatorcontrib><creatorcontrib>Wiggers, Theo</creatorcontrib><creatorcontrib>van der Sijp, Joost R. M. M</creatorcontrib><creatorcontrib>Verhoef, Cornelis</creatorcontrib><creatorcontrib>Graveland, Wilfried J</creatorcontrib><creatorcontrib>Eggermont, Alexander M. M</creatorcontrib><creatorcontrib>de Wilt, Johannes H. W</creatorcontrib><title>Preoperative Radiotherapy Improves Outcome in Recurrent Rectal Cancer</title><title>Diseases of the colon & rectum</title><addtitle>Dis Colon Rectum</addtitle><description>PURPOSE:
METHODS:
RESULTS:The median follow-up of patients alive for the total group was 16 (range, 4-156) months. Tumor characteristics were comparable between the two groups. Complete resections were performed in 64 percent of the patients who received preoperative radiation and 45 percent of the nonirradiated patients. A complete response after radiotherapy was found in 10 percent of the preoperative irradiated patients (n = 6). There were no differences in morbidity and reintervention rate between the two groups. Local control after preoperative radiotherapy was statistically significantly higher after three and five years (P = 0.036). Overall survival and metastases-free survival were not different in both groups. Complete response to preoperative radiotherapy was predictive for an improved survival.
CONCLUSIONS:</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Adjuvant</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0012-3706</issn><issn>1530-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtKAzEQhoMoWg8P4I0sgt6tTs7ZSylVCwVF9Dpkd6d0dQ812W3p25vaguBVMuGbmZ8vhFxSuKMA-j5Q4BJSAJGCyWiqDsiISh5fuDSHZARAWco1qBNyGsJnLIGBPiYnVGojjVEjMnn12C3Ru75aYfLmyqrrF7FcbpJps_TdCkPyMvRF12BStckbFoP32PbbW-_qZOzaAv05OZq7OuDF_jwjH4-T9_FzOnt5mo4fZmkhlBYpzU3GldM4z4E5wRjlUqnC0Ay4FiA1R55rLWTpFDguQDOUmchLaUrnJOdn5HY3Nyb7HjD0tqlCgXXtWuyGYJU2mZY8i-D1P_CzG3wbs1lG4ybJGESI7qDCdyF4nNulrxrnN5aC3Qq2O8E2CrZbwVbFnqv94CFvsPzr2BuNwM0ecKFw9dxHQVX445RRQmTbhGLHrbu6Rx--6mGN3i7Q1f0ibgTgQvKUAUhh4PeXYwz-A_1okEk</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Vermaas, Maarten</creator><creator>Ferenschild, Floris T. J</creator><creator>Nuyttens, Joost J. M. E</creator><creator>Marinelli, Andreas W. K. S</creator><creator>Wiggers, Theo</creator><creator>van der Sijp, Joost R. M. M</creator><creator>Verhoef, Cornelis</creator><creator>Graveland, Wilfried J</creator><creator>Eggermont, Alexander M. M</creator><creator>de Wilt, Johannes H. W</creator><general>The ASCRS</general><general>Springer</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>Preoperative Radiotherapy Improves Outcome in Recurrent Rectal Cancer</title><author>Vermaas, Maarten ; Ferenschild, Floris T. J ; Nuyttens, Joost J. M. E ; Marinelli, Andreas W. K. S ; Wiggers, Theo ; van der Sijp, Joost R. M. M ; Verhoef, Cornelis ; Graveland, Wilfried J ; Eggermont, Alexander M. M ; de Wilt, Johannes H. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4674-1b8936a7efb02a42213566c81903740573e3b7745da60a34072e594bd58daa533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - radiotherapy</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Adjuvant</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vermaas, Maarten</creatorcontrib><creatorcontrib>Ferenschild, Floris T. J</creatorcontrib><creatorcontrib>Nuyttens, Joost J. M. E</creatorcontrib><creatorcontrib>Marinelli, Andreas W. K. S</creatorcontrib><creatorcontrib>Wiggers, Theo</creatorcontrib><creatorcontrib>van der Sijp, Joost R. M. M</creatorcontrib><creatorcontrib>Verhoef, Cornelis</creatorcontrib><creatorcontrib>Graveland, Wilfried J</creatorcontrib><creatorcontrib>Eggermont, Alexander M. M</creatorcontrib><creatorcontrib>de Wilt, Johannes H. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diseases of the colon & rectum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vermaas, Maarten</au><au>Ferenschild, Floris T. 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METHODS:
RESULTS:The median follow-up of patients alive for the total group was 16 (range, 4-156) months. Tumor characteristics were comparable between the two groups. Complete resections were performed in 64 percent of the patients who received preoperative radiation and 45 percent of the nonirradiated patients. A complete response after radiotherapy was found in 10 percent of the preoperative irradiated patients (n = 6). There were no differences in morbidity and reintervention rate between the two groups. Local control after preoperative radiotherapy was statistically significantly higher after three and five years (P = 0.036). Overall survival and metastases-free survival were not different in both groups. Complete response to preoperative radiotherapy was predictive for an improved survival.
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| ispartof | Diseases of the colon & rectum, 2005-05, Vol.48 (5), p.918-928 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Combined Modality Therapy Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Neoplasm Recurrence, Local - surgery Preoperative Care Prognosis Proportional Hazards Models Prospective Studies Radiotherapy Dosage Radiotherapy, Adjuvant Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Treatment Outcome Tumors |
| title | Preoperative Radiotherapy Improves Outcome in Recurrent Rectal Cancer |
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