Identification of AMP N1-oxide in royal jelly as a component neurotrophic toward cultured rat pheochromocytoma PC12 cells

An extract of royal jelly (RJ) induced processes from cultured rat pheochromocytoma PC12 cells. Active components were isolated, and identified as adenosine monophosphate (AMP) and AMP Nsub(1) -oxide. AMP Nsub(1) oxide was more than 20 times as active as AMP, judging from the minimal concentration t...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2006-04, Vol.70 (4), p.897-906
Hauptverfasser:	Hattori, N.(Gifu Pharmaceutical Univ. (Japan)), Nomoto, H, Mishima, S, Inagaki, S, Goto, M, Sako, M, Furukawa, S
Format:	Artikel
Sprache:	eng
Schlagworte:	ABEILLE DOMESTIQUE ABEJA MELIFERA ABEJA REINA Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - chemistry Adenosine Monophosphate - isolation & purification Adenosine Monophosphate - pharmacology AMP Animals Biological and medical sciences Cell Movement - drug effects Cell Proliferation - drug effects Cell Shape Chromatography, Ion Exchange Fatty Acids - chemistry Fundamental and applied biological sciences. Psychology GELEE ROYALE HONEY BEES JALEA REAL Magnetic Resonance Spectroscopy Molecular Structure NEUROFISIOLOGIA Neurons - cytology Neurons - drug effects NEUROPHYSIOLOGIE NEUROPHYSIOLOGY Oxides - chemistry Oxides - isolation & purification Oxides - pharmacology PC12 Cells Purinergic P1 Receptor Agonists QUEEN BEES RAT RATA RATS Receptors, Purinergic P1 - metabolism REINE D'ABEILLE ROYAL JELLY Spectrometry, Mass, Electrospray Ionization
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