Direct Comparison of Umbilical Cord Blood versus Bone Marrow–Derived Endothelial Precursor Cells in Mediating Neovascularization in Response to Vascular Ischemia

Endothelial precursor cells (EPCs) cultured from adult bone marrow (BM) have been shown to mediate neovasculogenesis in murine models of vascular injury. We sought to directly compare umbilical cord blood (UCB)- and BM-derived EPC surface phenotypes and in vivo functional capacity. UCB and BM EPCs d...

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Veröffentlicht in:	Biology of blood and marrow transplantation 2006-05, Vol.12 (5), p.585-593
Hauptverfasser:	Finney, Marcie R., Greco, Nicholas J., Haynesworth, Stephen E., Martin, Joseph M., Hedrick, David P., Swan, Jimmy Z., Winter, Daniel G., Kadereit, Suzanne, Joseph, Matthew E., Fu, Pingfu, Pompili, Vincent J., Laughlin, Mary J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Bone Marrow Transplantation Capillaries - ultrastructure Cell Differentiation Cord Blood Stem Cell Transplantation Endothelial Cells - cytology Endothelial precursor cells Endothelium, Vascular - cytology Female Hindlimb - blood supply Humans Immunophenotyping Infant, Newborn Ischemia - physiopathology Ischemia - surgery Laser-Doppler Flowmetry Lipoproteins, LDL - metabolism Mice Mice, Inbred NOD Mice, SCID Muscle, Skeletal - blood supply Neovascularization Neovascularization, Physiologic - physiology Plant Lectins - metabolism Receptors, Cell Surface - metabolism Receptors, CXCR4 - biosynthesis Receptors, Scavenger - metabolism Stem Cells - classification Stem Cells - cytology Stromal Cells - cytology Transplantation, Heterologous Umbilical cord blood Vascular ischemia
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