Insulin stimulates arterial neointima formation in normal rats after balloon injury
Aim: Insulin resistance in patients is associated with increased atherosclerosis and arterial restenosis. It is thought that the concomitant hyperinsulinaemia exacerbates vascular disease because resistance to insulin‐induced glucose disposal is associated with resistance to certain effects of insu...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2006-05, Vol.8 (3), p.348-351 |
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| container_title | Diabetes, obesity & metabolism |
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| creator | Foster, E. Zhang, S. Kahn, A. M. |
| description | Aim: Insulin resistance in patients is associated with increased atherosclerosis and arterial restenosis. It is thought that the concomitant hyperinsulinaemia exacerbates vascular disease because resistance to insulin‐induced glucose disposal is associated with resistance to certain effects of insulin which inhibit, but with no resistance to other effects which promote, neointimal hyperplasia. We sought to determine the net effect of hyperinsulinaemia on neointimal hyperplasia in normal animals.
Methods: Rats were infused with or without insulin for 16 days and the carotid artery injured by balloon catheter on day 2.
Results: Steady‐state serum insulin concentrations were 0.56 ± 0.04 and 1.25 ± 0.05 nm for control and hyperinsulinaemic rats respectively (p |
| doi_str_mv | 10.1111/j.1463-1326.2005.00513.x |
| format | Article |
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Methods: Rats were infused with or without insulin for 16 days and the carotid artery injured by balloon catheter on day 2.
Results: Steady‐state serum insulin concentrations were 0.56 ± 0.04 and 1.25 ± 0.05 nm for control and hyperinsulinaemic rats respectively (p < 0.01). Systolic blood pressures, weights and serum glucose levels were not affected by hyperinsulinaemia. Fourteen days after injury, the neointima‐to‐media area ratio was 0.72 ± 0.07 and 1.39 ± 0.15 for control and hyperinsulinaemic rats respectively (p < 0.05). Media area was unaffected by hyperinsulinaemia.
Conclusions: The effects of hyperinsulinaemia which promote neointimal hyperplasia after balloon injury of rat carotid artery predominate over the effects which inhibit it even in normal animals.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/j.1463-1326.2005.00513.x</identifier><identifier>PMID: 16634996</identifier><language>eng</language><publisher>Oxford, UK; Malden, USA: Blackwell Publishing Ltd</publisher><subject>angioplasty ; Angioplasty, Balloon - adverse effects ; Animals ; atherosclerosis ; Blood Glucose - metabolism ; Blood Pressure ; Carotid Arteries - pathology ; diabetes ; Hyperinsulinism - blood ; Hyperinsulinism - complications ; Hyperinsulinism - pathology ; Hyperplasia - blood ; Hyperplasia - etiology ; Hyperplasia - physiopathology ; insulin ; Insulin - blood ; Insulin Resistance ; Male ; neointima ; Rats ; Rats, Sprague-Dawley ; Tunica Intima - pathology ; Tunica Media - pathology</subject><ispartof>Diabetes, obesity & metabolism, 2006-05, Vol.8 (3), p.348-351</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4043-204732555135687b2be5faae90ef796fc53b01514e39ba0288fcde8470ca7e533</citedby><cites>FETCH-LOGICAL-c4043-204732555135687b2be5faae90ef796fc53b01514e39ba0288fcde8470ca7e533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1463-1326.2005.00513.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1463-1326.2005.00513.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16634996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foster, E.</creatorcontrib><creatorcontrib>Zhang, S.</creatorcontrib><creatorcontrib>Kahn, A. M.</creatorcontrib><title>Insulin stimulates arterial neointima formation in normal rats after balloon injury</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aim: Insulin resistance in patients is associated with increased atherosclerosis and arterial restenosis. It is thought that the concomitant hyperinsulinaemia exacerbates vascular disease because resistance to insulin‐induced glucose disposal is associated with resistance to certain effects of insulin which inhibit, but with no resistance to other effects which promote, neointimal hyperplasia. We sought to determine the net effect of hyperinsulinaemia on neointimal hyperplasia in normal animals.
Methods: Rats were infused with or without insulin for 16 days and the carotid artery injured by balloon catheter on day 2.
Results: Steady‐state serum insulin concentrations were 0.56 ± 0.04 and 1.25 ± 0.05 nm for control and hyperinsulinaemic rats respectively (p < 0.01). Systolic blood pressures, weights and serum glucose levels were not affected by hyperinsulinaemia. Fourteen days after injury, the neointima‐to‐media area ratio was 0.72 ± 0.07 and 1.39 ± 0.15 for control and hyperinsulinaemic rats respectively (p < 0.05). Media area was unaffected by hyperinsulinaemia.
Conclusions: The effects of hyperinsulinaemia which promote neointimal hyperplasia after balloon injury of rat carotid artery predominate over the effects which inhibit it even in normal animals.</description><subject>angioplasty</subject><subject>Angioplasty, Balloon - adverse effects</subject><subject>Animals</subject><subject>atherosclerosis</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Carotid Arteries - pathology</subject><subject>diabetes</subject><subject>Hyperinsulinism - blood</subject><subject>Hyperinsulinism - complications</subject><subject>Hyperinsulinism - pathology</subject><subject>Hyperplasia - blood</subject><subject>Hyperplasia - etiology</subject><subject>Hyperplasia - physiopathology</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>neointima</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFFPgzAQxxujcXP6FQxPvoEtpVASX8zUOYPuQY2-NYWVpNjBbCFu395jLPPVJk2vvd__evdHyCM4ILCuq4BEMfUJDeMgxJgFsAkNNkdofEgc7-LQ5ykOR-jMuQpjHFGenKIRiWMapWk8Rq_z2nVG155r9aozslXOk7ZVVkvj1arRNbxLr2zsSra6qT1A6_5iPCtbYEtgvVwa0-ySVWe35-iklMapi_05Qe8P92_TRz9bzObT28wvImjED3GU0JAx6JzFPMnDXLFSSpViVSZpXBaM5pgwEima5hKHnJfFUvEowYVMFKN0gq6GumvbfHfKtWKlXaGMkdB450Sc8DSC6QHkA1jYxjmrSrG2MJXdCoJFb6ioRO-b6H0TvaFiZ6jYgPRy_0eXr9TyT7h3EICbAfjRRm3_XVjcLZ4hALk_yLVr1eYgl_YL2qcJEx8vM5HNMP3kT5ng9Bff8ZOV</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Foster, E.</creator><creator>Zhang, S.</creator><creator>Kahn, A. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Insulin stimulates arterial neointima formation in normal rats after balloon injury</title><author>Foster, E. ; Zhang, S. ; Kahn, A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4043-204732555135687b2be5faae90ef796fc53b01514e39ba0288fcde8470ca7e533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>angioplasty</topic><topic>Angioplasty, Balloon - adverse effects</topic><topic>Animals</topic><topic>atherosclerosis</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Carotid Arteries - pathology</topic><topic>diabetes</topic><topic>Hyperinsulinism - blood</topic><topic>Hyperinsulinism - complications</topic><topic>Hyperinsulinism - pathology</topic><topic>Hyperplasia - blood</topic><topic>Hyperplasia - etiology</topic><topic>Hyperplasia - physiopathology</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>neointima</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Foster, E.</creatorcontrib><creatorcontrib>Zhang, S.</creatorcontrib><creatorcontrib>Kahn, A. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foster, E.</au><au>Zhang, S.</au><au>Kahn, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin stimulates arterial neointima formation in normal rats after balloon injury</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2006-05</date><risdate>2006</risdate><volume>8</volume><issue>3</issue><spage>348</spage><epage>351</epage><pages>348-351</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Aim: Insulin resistance in patients is associated with increased atherosclerosis and arterial restenosis. It is thought that the concomitant hyperinsulinaemia exacerbates vascular disease because resistance to insulin‐induced glucose disposal is associated with resistance to certain effects of insulin which inhibit, but with no resistance to other effects which promote, neointimal hyperplasia. We sought to determine the net effect of hyperinsulinaemia on neointimal hyperplasia in normal animals.
Methods: Rats were infused with or without insulin for 16 days and the carotid artery injured by balloon catheter on day 2.
Results: Steady‐state serum insulin concentrations were 0.56 ± 0.04 and 1.25 ± 0.05 nm for control and hyperinsulinaemic rats respectively (p < 0.01). Systolic blood pressures, weights and serum glucose levels were not affected by hyperinsulinaemia. Fourteen days after injury, the neointima‐to‐media area ratio was 0.72 ± 0.07 and 1.39 ± 0.15 for control and hyperinsulinaemic rats respectively (p < 0.05). Media area was unaffected by hyperinsulinaemia.
Conclusions: The effects of hyperinsulinaemia which promote neointimal hyperplasia after balloon injury of rat carotid artery predominate over the effects which inhibit it even in normal animals.</abstract><cop>Oxford, UK; Malden, USA</cop><pub>Blackwell Publishing Ltd</pub><pmid>16634996</pmid><doi>10.1111/j.1463-1326.2005.00513.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Diabetes, obesity & metabolism, 2006-05, Vol.8 (3), p.348-351 |
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| source | MEDLINE; Wiley Online Library Journals |
| subjects | angioplasty Angioplasty, Balloon - adverse effects Animals atherosclerosis Blood Glucose - metabolism Blood Pressure Carotid Arteries - pathology diabetes Hyperinsulinism - blood Hyperinsulinism - complications Hyperinsulinism - pathology Hyperplasia - blood Hyperplasia - etiology Hyperplasia - physiopathology insulin Insulin - blood Insulin Resistance Male neointima Rats Rats, Sprague-Dawley Tunica Intima - pathology Tunica Media - pathology |
| title | Insulin stimulates arterial neointima formation in normal rats after balloon injury |
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