WST11, A Novel Water-soluble Bacteriochlorophyll Derivative; Cellular Uptake, Pharmacokinetics, Biodistribution and Vascular-targeted Photodynamic Activity Using Melanoma Tumors as a Model

WST11 is a novel negatively charged water-soluble palladium-bacteriochlorophyll derivative that was developed for vascular-targeted photodynamic therapy (VTP) in our laboratory. The in vitro results suggest that WST11 cellular uptake, clearance and phototoxicity are mediated by serum albumin traffic...

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Veröffentlicht in:	Photochemistry and photobiology 2005-03, Vol.81 (2), p.342-351
Hauptverfasser:	Mazor, Ohad, Brandis, Alexander, Plaks, Vicki, Neumark, Eran, Rosenbach-Belkin, Varda, Salomon, Yoram, Scherz, Avigdor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriochlorophylls - chemistry Bacteriochlorophylls - pharmacokinetics Bacteriochlorophylls - therapeutic use Cell Line, Tumor Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - radiation effects In Vitro Techniques Light Male Melanoma, Experimental - blood supply Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Mice Mice, Nude Molecular Structure Photochemotherapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Rats Rats, Wistar Research s Serum Albumin, Bovine - pharmacology Solubility Sucrose - pharmacology Time Factors Tissue Distribution Water - chemistry Xenograft Model Antitumor Assays
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