Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German population
In human populations, the correct historical interpretation of a genetic structure is often hampered by an almost inherent inability to differentiate between ancient and more recent influences upon extant gene pools. One method to trace recent population movements is the analysis of surnames, which,...
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| Veröffentlicht in: | European journal of human genetics : EJHG 2006-05, Vol.14 (5), p.577-582 |
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| container_title | European journal of human genetics : EJHG |
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| creator | Immel, Uta-Dorothee Krawczak, Michael Udolph, Jürgen Richter, Angela Rodig, Heike Kleiber, Manfred Klintschar, Michael |
| description | In human populations, the correct historical interpretation of a genetic structure is often hampered by an almost inherent inability to differentiate between ancient and more recent influences upon extant gene pools. One method to trace recent population movements is the analysis of surnames, which, at least in Central Europe, can be thought of as traits ‘linked’ to the Y chromosome. Illegitimacy, extramarital birth and changes of surnames may have substantially obscured this linkage. In order to assess the actual extent of correlation between surnames and Y-chromosomal haplotypes in Central Europe, we typed Y-chromosomal short tandem repeat markers in 419 German males from Halle. These individuals were subdivided into three groups according to the origin of their respective surname, namely German (G), Slavic (S) or ‘Mixed’ (M). The distribution of the haplotypes was compared by Analysis of Molecular Variance. While the M group was indistinguishable from group G (Φ
ST
=−0.0008,
P
>0.5), a highly significant difference (Φ
ST
=0.0277,
P |
| doi_str_mv | 10.1038/sj.ejhg.5201572 |
| format | Article |
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ST
=−0.0008,
P
>0.5), a highly significant difference (Φ
ST
=0.0277,
P
<0.001) was observed between the S group and the combined G+M group. This surprisingly strong differentiation is comparable to that of European populations of much larger geographic and linguistic difference. In view of the major migration from Slavic countries into Germany in the 19th century, it appears likely that the observed concurrence of Slavic surnames and Y chromosomes is of a recent rather than an early origin. Our results suggest that surnames may provide a simple means to stratify, and thereby to render more efficient, Y-chromosomal analyses of Central Europeans that target more ancient events.</description><identifier>ISSN: 1018-4813</identifier><identifier>EISSN: 1476-5438</identifier><identifier>DOI: 10.1038/sj.ejhg.5201572</identifier><identifier>PMID: 16435000</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Bioinformatics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Birth ; Chromosomes ; Chromosomes, Human, Y - ultrastructure ; Cytogenetics ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; European Continental Ancestry Group ; Gene Expression ; Gene Frequency ; General aspects. Genetic counseling ; Genetic structure ; Genetic testing ; Genetic Variation ; Genetics, Population ; Genotype ; Germany ; Haplotypes ; Human Genetics ; Humans ; Legal medicine ; Male ; Males ; Medical genetics ; Medical sciences ; Migration ; Mutation ; Poland ; Population genetics ; Software ; Studies ; Writers ; Y Chromosomes</subject><ispartof>European journal of human genetics : EJHG, 2006-05, Vol.14 (5), p.577-582</ispartof><rights>Springer Nature Switzerland AG 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-2cf1871e3ac8dc0b1d2eb1fe55e9417aecb30793329d756ecadb23f31fda3c833</citedby><cites>FETCH-LOGICAL-c465t-2cf1871e3ac8dc0b1d2eb1fe55e9417aecb30793329d756ecadb23f31fda3c833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejhg.5201572$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejhg.5201572$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17693607$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16435000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Immel, Uta-Dorothee</creatorcontrib><creatorcontrib>Krawczak, Michael</creatorcontrib><creatorcontrib>Udolph, Jürgen</creatorcontrib><creatorcontrib>Richter, Angela</creatorcontrib><creatorcontrib>Rodig, Heike</creatorcontrib><creatorcontrib>Kleiber, Manfred</creatorcontrib><creatorcontrib>Klintschar, Michael</creatorcontrib><title>Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German population</title><title>European journal of human genetics : EJHG</title><addtitle>Eur J Hum Genet</addtitle><addtitle>Eur J Hum Genet</addtitle><description>In human populations, the correct historical interpretation of a genetic structure is often hampered by an almost inherent inability to differentiate between ancient and more recent influences upon extant gene pools. One method to trace recent population movements is the analysis of surnames, which, at least in Central Europe, can be thought of as traits ‘linked’ to the Y chromosome. Illegitimacy, extramarital birth and changes of surnames may have substantially obscured this linkage. In order to assess the actual extent of correlation between surnames and Y-chromosomal haplotypes in Central Europe, we typed Y-chromosomal short tandem repeat markers in 419 German males from Halle. These individuals were subdivided into three groups according to the origin of their respective surname, namely German (G), Slavic (S) or ‘Mixed’ (M). The distribution of the haplotypes was compared by Analysis of Molecular Variance. While the M group was indistinguishable from group G (Φ
ST
=−0.0008,
P
>0.5), a highly significant difference (Φ
ST
=0.0277,
P
<0.001) was observed between the S group and the combined G+M group. This surprisingly strong differentiation is comparable to that of European populations of much larger geographic and linguistic difference. In view of the major migration from Slavic countries into Germany in the 19th century, it appears likely that the observed concurrence of Slavic surnames and Y chromosomes is of a recent rather than an early origin. Our results suggest that surnames may provide a simple means to stratify, and thereby to render more efficient, Y-chromosomal analyses of Central Europeans that target more ancient events.</description><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Birth</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Y - ultrastructure</subject><subject>Cytogenetics</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>European Continental Ancestry Group</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>General aspects. Genetic counseling</subject><subject>Genetic structure</subject><subject>Genetic testing</subject><subject>Genetic Variation</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Germany</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Legal medicine</subject><subject>Male</subject><subject>Males</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Migration</subject><subject>Mutation</subject><subject>Poland</subject><subject>Population genetics</subject><subject>Software</subject><subject>Studies</subject><subject>Writers</subject><subject>Y Chromosomes</subject><issn>1018-4813</issn><issn>1476-5438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0UGL1TAQB_Aiiruunr1JEPTWt0nTNOlRlnUVFgRdD57CNJ3ua0mbmmkX3rc3j1d4IIinBOY3kzD_LHsr-E5waa5p2OGwf9ypgguli2fZpSh1latSmufpzoXJSyPkRfaKaOA8FbV4mV2IqpSKc36Ztb9yt49hDBRG8OzHw3e2h9mH5TAjgwn8gXpiEZ8QPDFa4wQj5kAUXA8LtoyWCAuwfmLLHtkt0JLfYRxhYnOYVw9LH6bX2YsuteOb7bzKfn6-fbj5kt9_u_t68-k-d2WllrxwnTBaoARnWscb0RbYiA6VwroUGtA1kutayqJutarQQdsUspOia0E6I-VV9vE0d47h94q02LEnh97DhGElW2lTpwn8v1DoouRSmQTf_wWHcNyBJ1sIbaq0Q5XQ9Qm5GIgidnaO_QjxYAW3x5gsDfYYk91iSh3vtrFrM2J79lsuCXzYAJAD30WYXE9np6taVlwnx0-OUml6xHj-37_e_gNGAK1O</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Immel, Uta-Dorothee</creator><creator>Krawczak, Michael</creator><creator>Udolph, Jürgen</creator><creator>Richter, Angela</creator><creator>Rodig, Heike</creator><creator>Kleiber, Manfred</creator><creator>Klintschar, Michael</creator><general>Springer International Publishing</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German population</title><author>Immel, Uta-Dorothee ; Krawczak, Michael ; Udolph, Jürgen ; Richter, Angela ; Rodig, Heike ; Kleiber, Manfred ; Klintschar, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-2cf1871e3ac8dc0b1d2eb1fe55e9417aecb30793329d756ecadb23f31fda3c833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Birth</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Y - ultrastructure</topic><topic>Cytogenetics</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>European Continental Ancestry Group</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>General aspects. Genetic counseling</topic><topic>Genetic structure</topic><topic>Genetic testing</topic><topic>Genetic Variation</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Germany</topic><topic>Haplotypes</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Legal medicine</topic><topic>Male</topic><topic>Males</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Migration</topic><topic>Mutation</topic><topic>Poland</topic><topic>Population genetics</topic><topic>Software</topic><topic>Studies</topic><topic>Writers</topic><topic>Y Chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Immel, Uta-Dorothee</creatorcontrib><creatorcontrib>Krawczak, Michael</creatorcontrib><creatorcontrib>Udolph, Jürgen</creatorcontrib><creatorcontrib>Richter, Angela</creatorcontrib><creatorcontrib>Rodig, Heike</creatorcontrib><creatorcontrib>Kleiber, Manfred</creatorcontrib><creatorcontrib>Klintschar, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of human genetics : EJHG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Immel, Uta-Dorothee</au><au>Krawczak, Michael</au><au>Udolph, Jürgen</au><au>Richter, Angela</au><au>Rodig, Heike</au><au>Kleiber, Manfred</au><au>Klintschar, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German population</atitle><jtitle>European journal of human genetics : EJHG</jtitle><stitle>Eur J Hum Genet</stitle><addtitle>Eur J Hum Genet</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>14</volume><issue>5</issue><spage>577</spage><epage>582</epage><pages>577-582</pages><issn>1018-4813</issn><eissn>1476-5438</eissn><abstract>In human populations, the correct historical interpretation of a genetic structure is often hampered by an almost inherent inability to differentiate between ancient and more recent influences upon extant gene pools. One method to trace recent population movements is the analysis of surnames, which, at least in Central Europe, can be thought of as traits ‘linked’ to the Y chromosome. Illegitimacy, extramarital birth and changes of surnames may have substantially obscured this linkage. In order to assess the actual extent of correlation between surnames and Y-chromosomal haplotypes in Central Europe, we typed Y-chromosomal short tandem repeat markers in 419 German males from Halle. These individuals were subdivided into three groups according to the origin of their respective surname, namely German (G), Slavic (S) or ‘Mixed’ (M). The distribution of the haplotypes was compared by Analysis of Molecular Variance. While the M group was indistinguishable from group G (Φ
ST
=−0.0008,
P
>0.5), a highly significant difference (Φ
ST
=0.0277,
P
<0.001) was observed between the S group and the combined G+M group. This surprisingly strong differentiation is comparable to that of European populations of much larger geographic and linguistic difference. In view of the major migration from Slavic countries into Germany in the 19th century, it appears likely that the observed concurrence of Slavic surnames and Y chromosomes is of a recent rather than an early origin. Our results suggest that surnames may provide a simple means to stratify, and thereby to render more efficient, Y-chromosomal analyses of Central Europeans that target more ancient events.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>16435000</pmid><doi>10.1038/sj.ejhg.5201572</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedicine Birth Chromosomes Chromosomes, Human, Y - ultrastructure Cytogenetics Deoxyribonucleic acid DNA DNA - chemistry European Continental Ancestry Group Gene Expression Gene Frequency General aspects. Genetic counseling Genetic structure Genetic testing Genetic Variation Genetics, Population Genotype Germany Haplotypes Human Genetics Humans Legal medicine Male Males Medical genetics Medical sciences Migration Mutation Poland Population genetics Software Studies Writers Y Chromosomes |
| title | Y-chromosomal STR haplotype analysis reveals surname-associated strata in the East-German population |
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