8-chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells

8-Chloro-cyclic AMP (8-Cl-cAMP), which is known to induce growth inhibition, apoptosis, and differentiation in various cancer cell lines, has been studied as a putative anticancer drug. However, the mechanism of anticancer activities of 8-Cl-cAMP has not been fully understood. Previously, we reporte...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-06, Vol.65 (11), p.4896-4901
Hauptverfasser:	AHN, Young-Ho, JOONG MOK JUNG, SEUNG HWAN HONG
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Chloroadenosine - analogs & derivatives 2-Chloroadenosine - pharmacology 8-Bromo Cyclic Adenosine Monophosphate - analogs & derivatives 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell Growth Processes - drug effects Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation - drug effects HL-60 Cells Humans K562 Cells MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical sciences p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Tumors
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