Wnt signalling and prostate cancer
The Wnt signalling pathway plays a role in the direction of embryological development and maintenance of stem cell populations. Heritable alterations in genes encoding molecules of the Wnt pathway, including mutation and epigenetic events, have been demonstrated in a variety of cancers. It has been...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2005-06, Vol.8 (2), p.119-126 |
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| container_title | Prostate cancer and prostatic diseases |
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| creator | Yardy, G W Brewster, S F |
| description | The Wnt signalling pathway plays a role in the direction of embryological development and maintenance of stem cell populations. Heritable alterations in genes encoding molecules of the Wnt pathway, including mutation and epigenetic events, have been demonstrated in a variety of cancers. It has been proposed that disruption of this pathway is a significant step in the development of many tumours. Interactions between
β
-catenin—the effector molecule of the Wnt pathway—and the androgen receptor highlight the pathway's relevance to urological malignancy. Mutation or altered expression of Wnt genes in tumours may give prognostic information and treatments are being developed which target this pathway. |
| doi_str_mv | 10.1038/sj.pcan.4500794 |
| format | Article |
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β
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β
-catenin—the effector molecule of the Wnt pathway—and the androgen receptor highlight the pathway's relevance to urological malignancy. Mutation or altered expression of Wnt genes in tumours may give prognostic information and treatments are being developed which target this pathway.</description><subject>Androgen receptors</subject><subject>beta Catenin</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cytoskeletal Proteins - physiology</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins - physiology</subject><subject>Male</subject><subject>Malignancy</subject><subject>Mutation</subject><subject>Prognosis</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Protein-Tyrosine Kinases</subject><subject>Receptors, Androgen - physiology</subject><subject>review</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Stem cells</subject><subject>Trans-Activators - physiology</subject><subject>Tumors</subject><subject>Wnt protein</subject><subject>Wnt Proteins</subject><subject>β-Catenin</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1PGzEQxa2KqnyUM6dWEZV62zD-Xh8RohQJqZcijpbjnQ0bbbzB9h7473G6KRFIyAdb9m_evPEj5IzCnAKvL9JqvvEuzIUE0EZ8IkdUaFVJBfVBOXMlK11LdkiOU1oBgKEGvpBDKmswSpkjcv4Q8ix1y-D6vgvLmQvNbBOHlF3GWVH2GL-Sz63rE57u9hNy_-v679Xv6u7Pze3V5V3lJRO5ohLpAhqunUPqJNfFX9PKBRZHsPB127LWo1cCkDNgDVBDlXRGaN04xgU_IT8n3dL_acSU7bpLHvveBRzGZJWuDasVFPDHO3A1jLFMkCxTQnLGqOaFOv-QYgak1mwLzSdo6Xq0XWiHHJ0vq8F154eAbVfuL2npLGRtYG_yX8Ejuj4_pqEfczeE9Ba8mEBffjNFbO0mdmsXny0Fu83OppXdZmd32ZWK7zvD42KNzZ7fhVUAmIBUnsIS436ijzW_TSXB5THiq-b_9xcIgquG</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Yardy, G W</creator><creator>Brewster, S F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Wnt signalling and prostate cancer</title><author>Yardy, G W ; Brewster, S F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-15e1b0d37aae1a537038df5be1470bc8ff2fcec640e3202d019165a9477da2343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Androgen receptors</topic><topic>beta Catenin</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cytoskeletal Proteins - physiology</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Intercellular Signaling Peptides and Proteins - physiology</topic><topic>Male</topic><topic>Malignancy</topic><topic>Mutation</topic><topic>Prognosis</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Protein-Tyrosine Kinases</topic><topic>Receptors, Androgen - physiology</topic><topic>review</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Stem cells</topic><topic>Trans-Activators - physiology</topic><topic>Tumors</topic><topic>Wnt protein</topic><topic>Wnt Proteins</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yardy, G W</creatorcontrib><creatorcontrib>Brewster, S F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yardy, G W</au><au>Brewster, S F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt signalling and prostate cancer</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>8</volume><issue>2</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract>The Wnt signalling pathway plays a role in the direction of embryological development and maintenance of stem cell populations. 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β
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| subjects | Androgen receptors beta Catenin Biomedical and Life Sciences Biomedicine Cancer Research Cell Transformation, Neoplastic Cytoskeletal Proteins - physiology Epigenetics Gene expression Genes Humans Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - physiology Male Malignancy Mutation Prognosis Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - physiopathology Prostatic Neoplasms - therapy Protein-Tyrosine Kinases Receptors, Androgen - physiology review Signal Transduction Signaling Stem cells Trans-Activators - physiology Tumors Wnt protein Wnt Proteins β-Catenin |
| title | Wnt signalling and prostate cancer |
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