The rTS Signaling Pathway as a Target for Drug Development
The rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overexpression can cause the downregulation of TS protein...
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| Veröffentlicht in: | Clinical colorectal cancer 2005-05, Vol.5 (1), p.57-60 |
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| container_title | Clinical colorectal cancer |
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| creator | Dolnick, Bruce J. |
| description | The
rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that
rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overexpression can cause the downregulation of TS protein in a colon cancer cell line through the production of ≥ 1 previously unknown signaling molecules. This observation signified the presence of a previously unidentified signaling pathway. The existence of a signaling pathway that can regulate TS protein levels and the widespread expression of the rTβ protein suggests that a new target for drug development may be on the horizon. This review describes the relationship between the
rTS and
TS genes and the known and potential effects of rTS RNAs and rTS proteins. We also present the structure of an identified TS downregulatory compound that may serve as a lead compound for development. |
| doi_str_mv | 10.3816/CCC.2005.n.017 |
| format | Article |
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rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that
rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overexpression can cause the downregulation of TS protein in a colon cancer cell line through the production of ≥ 1 previously unknown signaling molecules. This observation signified the presence of a previously unidentified signaling pathway. The existence of a signaling pathway that can regulate TS protein levels and the widespread expression of the rTβ protein suggests that a new target for drug development may be on the horizon. This review describes the relationship between the
rTS and
TS genes and the known and potential effects of rTS RNAs and rTS proteins. We also present the structure of an identified TS downregulatory compound that may serve as a lead compound for development.</description><identifier>ISSN: 1533-0028</identifier><identifier>EISSN: 1938-0674</identifier><identifier>DOI: 10.3816/CCC.2005.n.017</identifier><identifier>PMID: 15929807</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acyl-homocysteine lactone ; Antineoplastic Agents - pharmacology ; Antisense RNA ; Down-Regulation ; Growth regulation ; Humans ; Neoplasms - drug therapy ; Neoplasms - enzymology ; Neoplasms - physiopathology ; Recombinant Proteins ; RNA, Antisense ; RNA, Messenger ; Signal Transduction ; Thymidylate synthase ; Thymidylate Synthase - biosynthesis ; Thymidylate Synthase - genetics ; Thymidylate Synthase - metabolism</subject><ispartof>Clinical colorectal cancer, 2005-05, Vol.5 (1), p.57-60</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c257t-5c9e9f20a12a984597e17a4ef6e523afd316a1c6685b4fcb22e8b4cbc21fac5d3</citedby><cites>FETCH-LOGICAL-c257t-5c9e9f20a12a984597e17a4ef6e523afd316a1c6685b4fcb22e8b4cbc21fac5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3816/CCC.2005.n.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15929807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dolnick, Bruce J.</creatorcontrib><title>The rTS Signaling Pathway as a Target for Drug Development</title><title>Clinical colorectal cancer</title><addtitle>Clin Colorectal Cancer</addtitle><description>The
rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that
rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overexpression can cause the downregulation of TS protein in a colon cancer cell line through the production of ≥ 1 previously unknown signaling molecules. This observation signified the presence of a previously unidentified signaling pathway. The existence of a signaling pathway that can regulate TS protein levels and the widespread expression of the rTβ protein suggests that a new target for drug development may be on the horizon. This review describes the relationship between the
rTS and
TS genes and the known and potential effects of rTS RNAs and rTS proteins. We also present the structure of an identified TS downregulatory compound that may serve as a lead compound for development.</description><subject>Acyl-homocysteine lactone</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antisense RNA</subject><subject>Down-Regulation</subject><subject>Growth regulation</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - enzymology</subject><subject>Neoplasms - physiopathology</subject><subject>Recombinant Proteins</subject><subject>RNA, Antisense</subject><subject>RNA, Messenger</subject><subject>Signal Transduction</subject><subject>Thymidylate synthase</subject><subject>Thymidylate Synthase - biosynthesis</subject><subject>Thymidylate Synthase - genetics</subject><subject>Thymidylate Synthase - metabolism</subject><issn>1533-0028</issn><issn>1938-0674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EolBYGZEntgTbiWObDaW8pEogNcyW49ykQXkUOynqvydVKzEx3TN850j3Q-iGkjCSNLlP0zRkhPCwCwkVJ-iCqkgGJBHx6ZR5FAWEMDlDl95_TSmJKD1HM8oVU5KIC_SQrQG7bIVXddWZpu4q_GGG9Y_ZYeOxwZlxFQy47B1euLHCC9hC029a6IYrdFaaxsP18c7R5_NTlr4Gy_eXt_RxGVjGxRBwq0CVjBjKjJIxVwKoMDGUCXAWmbKIaGKoTRLJ87i0OWMg89jmltHSWF5Ec3R32N24_nsEP-i29haaxnTQj14nQiomVDyB4QG0rvfeQak3rm6N22lK9N6WnmzpvS3d6cnWVLg9Lo95C8UfftQzAfIAwPTftganva2hs1DUDuygi77-b_sXjNx3Ng</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Dolnick, Bruce J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>The rTS Signaling Pathway as a Target for Drug Development</title><author>Dolnick, Bruce J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-5c9e9f20a12a984597e17a4ef6e523afd316a1c6685b4fcb22e8b4cbc21fac5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acyl-homocysteine lactone</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antisense RNA</topic><topic>Down-Regulation</topic><topic>Growth regulation</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - enzymology</topic><topic>Neoplasms - physiopathology</topic><topic>Recombinant Proteins</topic><topic>RNA, Antisense</topic><topic>RNA, Messenger</topic><topic>Signal Transduction</topic><topic>Thymidylate synthase</topic><topic>Thymidylate Synthase - biosynthesis</topic><topic>Thymidylate Synthase - genetics</topic><topic>Thymidylate Synthase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dolnick, Bruce J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical colorectal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dolnick, Bruce J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rTS Signaling Pathway as a Target for Drug Development</atitle><jtitle>Clinical colorectal cancer</jtitle><addtitle>Clin Colorectal Cancer</addtitle><date>2005-05</date><risdate>2005</risdate><volume>5</volume><issue>1</issue><spage>57</spage><epage>60</epage><pages>57-60</pages><issn>1533-0028</issn><eissn>1938-0674</eissn><abstract>The
rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that
rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overexpression can cause the downregulation of TS protein in a colon cancer cell line through the production of ≥ 1 previously unknown signaling molecules. This observation signified the presence of a previously unidentified signaling pathway. The existence of a signaling pathway that can regulate TS protein levels and the widespread expression of the rTβ protein suggests that a new target for drug development may be on the horizon. This review describes the relationship between the
rTS and
TS genes and the known and potential effects of rTS RNAs and rTS proteins. We also present the structure of an identified TS downregulatory compound that may serve as a lead compound for development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15929807</pmid><doi>10.3816/CCC.2005.n.017</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1533-0028 |
| ispartof | Clinical colorectal cancer, 2005-05, Vol.5 (1), p.57-60 |
| issn | 1533-0028 1938-0674 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acyl-homocysteine lactone Antineoplastic Agents - pharmacology Antisense RNA Down-Regulation Growth regulation Humans Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - physiopathology Recombinant Proteins RNA, Antisense RNA, Messenger Signal Transduction Thymidylate synthase Thymidylate Synthase - biosynthesis Thymidylate Synthase - genetics Thymidylate Synthase - metabolism |
| title | The rTS Signaling Pathway as a Target for Drug Development |
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