Expression Patterns of Plasma Proteins in Spontaneously Diabetic Rats after Oral Administration of a Kampo Medicine, Hachimi-jio-gan, Using SELDI ProteinChip Platform

We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2005, Vol.28(6), pp.1031-1037
Hauptverfasser:	Kiga, Chizuru, Nakagawa, Takako, Koizumi, Keiichi, Sakurai, Hiroaki, Shibagaki, Yukari, Ogawa, Kazuo, Goto, Hirozo, Saiki, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biomarker Blood Proteins - biosynthesis Blood Proteins - genetics Diabetes Mellitus - drug therapy Diabetes Mellitus - genetics Diabetes Mellitus - metabolism diabetic WBN/Kob rat Drugs, Chinese Herbal - administration & dosage Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Hachimi-jio-gan Kampo medicine Male Medicine, Kampo Protein Array Analysis - methods Protein Chip Rats Rats, Wistar surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS)
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