Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class...
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| Veröffentlicht in: | Development (Cambridge) 2005-06, Vol.132 (12), p.2809-2823 |
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| creator | Kobayashi, Akio Kwan, Kin-Ming Carroll, Thomas J McMahon, Andrew P Mendelsohn, Cathy L Behringer, Richard R |
| description | Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1 -null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract. |
| doi_str_mv | 10.1242/dev.01858 |
| format | Article |
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Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1 -null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.01858</identifier><identifier>PMID: 15930111</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Animals ; Body Patterning - genetics ; Epithelium - metabolism ; Gene Expression Regulation, Developmental ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Kidney - abnormalities ; Kidney - embryology ; Kidney - metabolism ; LIM-Homeodomain Proteins ; Mesoderm - cytology ; Mesoderm - metabolism ; Mice ; Mice, Knockout ; Mice, Transgenic ; Morphogenesis ; Mutation - genetics ; Organ Specificity ; Phenotype ; Transcription Factors</subject><ispartof>Development (Cambridge), 2005-06, Vol.132 (12), p.2809-2823</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-d421a02cc9020fd95eeb34d0492481669c8304a1d1d466bc0fbd3ca082ef4b203</citedby><cites>FETCH-LOGICAL-c283t-d421a02cc9020fd95eeb34d0492481669c8304a1d1d466bc0fbd3ca082ef4b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3664,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15930111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Akio</creatorcontrib><creatorcontrib>Kwan, Kin-Ming</creatorcontrib><creatorcontrib>Carroll, Thomas J</creatorcontrib><creatorcontrib>McMahon, Andrew P</creatorcontrib><creatorcontrib>Mendelsohn, Cathy L</creatorcontrib><creatorcontrib>Behringer, Richard R</creatorcontrib><title>Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1 -null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract.</description><subject>Animals</subject><subject>Body Patterning - genetics</subject><subject>Epithelium - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Kidney - abnormalities</subject><subject>Kidney - embryology</subject><subject>Kidney - metabolism</subject><subject>LIM-Homeodomain Proteins</subject><subject>Mesoderm - cytology</subject><subject>Mesoderm - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Morphogenesis</subject><subject>Mutation - genetics</subject><subject>Organ Specificity</subject><subject>Phenotype</subject><subject>Transcription Factors</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRS0EYpqGBT-AvEJikcavPLxEw2ukRmxgbTl2pWNI4uByBuYX-Go8dEssWZVUdXSrbl1CnnN24EKJ1x5uD4x3dfeA7Lhq20pzoR-SHdM1q7jW_Io8QfzGGJNN2z4mV7zWknHOd-T324A5LC5Tu3iK8GODJQc70RwQN6hwBReG4Kh1OdyGHABpHGgegR5vPlVusoh0jDPEPv6iJ1hKP8ycDjHRvPXbZBOdY1rHeD_DgNRvKSwn-j34Be5oOR2muM5l61PyaLATwrNL3ZOv7999uf5YHT9_uLl-c6yc6GSuvBLcMuGcZoINXtcAvVSeKS1Ux5tGu04yZbnnXjVN79jQe-ks6wQMqhdM7snLs-6aYrGL2cwBHUyTXSBuaJq2K1Ky_i_I20bJtqB78uoMuhQREwxmTWG26c5wZu4TMsWm-ZtQYV9cRLd-Bv-PvERSgMMZGMNp_BkSmD7EKZ5KTmgu7zJciiJsRMe0_AO2jZ6o</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Kobayashi, Akio</creator><creator>Kwan, Kin-Ming</creator><creator>Carroll, Thomas J</creator><creator>McMahon, Andrew P</creator><creator>Mendelsohn, Cathy L</creator><creator>Behringer, Richard R</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development</title><author>Kobayashi, Akio ; Kwan, Kin-Ming ; Carroll, Thomas J ; McMahon, Andrew P ; Mendelsohn, Cathy L ; Behringer, Richard R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-d421a02cc9020fd95eeb34d0492481669c8304a1d1d466bc0fbd3ca082ef4b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Body Patterning - genetics</topic><topic>Epithelium - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Kidney - abnormalities</topic><topic>Kidney - embryology</topic><topic>Kidney - metabolism</topic><topic>LIM-Homeodomain Proteins</topic><topic>Mesoderm - cytology</topic><topic>Mesoderm - metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Morphogenesis</topic><topic>Mutation - genetics</topic><topic>Organ Specificity</topic><topic>Phenotype</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Akio</creatorcontrib><creatorcontrib>Kwan, Kin-Ming</creatorcontrib><creatorcontrib>Carroll, Thomas J</creatorcontrib><creatorcontrib>McMahon, Andrew P</creatorcontrib><creatorcontrib>Mendelsohn, Cathy L</creatorcontrib><creatorcontrib>Behringer, Richard R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Akio</au><au>Kwan, Kin-Ming</au><au>Carroll, Thomas J</au><au>McMahon, Andrew P</au><au>Mendelsohn, Cathy L</au><au>Behringer, Richard R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>132</volume><issue>12</issue><spage>2809</spage><epage>2823</epage><pages>2809-2823</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1 -null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. 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| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2005-06, Vol.132 (12), p.2809-2823 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Body Patterning - genetics Epithelium - metabolism Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Kidney - abnormalities Kidney - embryology Kidney - metabolism LIM-Homeodomain Proteins Mesoderm - cytology Mesoderm - metabolism Mice Mice, Knockout Mice, Transgenic Morphogenesis Mutation - genetics Organ Specificity Phenotype Transcription Factors |
| title | Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development |
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