Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans
The antibacterial activity of quaternary ammonium polyethylenimine (PEI) nanoparticles embedded at 1% w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with Streptoccocus mutans by: (i) t...
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| Veröffentlicht in: | Biomaterials 2006-07, Vol.27 (21), p.3995-4002 |
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| creator | Beyth, Nurit Yudovin-Farber, Ira Bahir, Ran Domb, Abraham J. Weiss, Ervin I. |
| description | The antibacterial activity of quaternary ammonium polyethylenimine (PEI) nanoparticles embedded at 1%
w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with
Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (
p |
| doi_str_mv | 10.1016/j.biomaterials.2006.03.003 |
| format | Article |
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w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with
Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (
p<0.001) was found in all three types of composite resins incorporated with the synthesized nanoparticles. The effect lasted for at least 1 month. SEM demonstrated bacterial debris and no streptococcal chains at 24
h of bacterial contact. The addition of 1%
w/w of nanoparticles did not affect the flexural modulus and the flexural strength of the dental composite materials.The results indicate that quaternary ammonium PEI nanoparticles immobilized in resin-based materials have a strong antibacterial activity upon contact without leach-out of the nanoparticles and without compromise in mechanical properties.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2006.03.003</identifier><identifier>PMID: 16564083</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - chemistry ; Antibacterial ; Cell Survival - drug effects ; Coated Materials, Biocompatible - administration & dosage ; Coated Materials, Biocompatible - chemistry ; Composite Resins - chemistry ; Dental composite ; Dental Materials - chemistry ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Materials Testing ; Nanoparticles ; Nanostructures - chemistry ; Nanostructures - ultrastructure ; Particle Size ; Polyethyleneimine - administration & dosage ; Polyethyleneimine - chemistry ; Polyethylenimine ; Quaternary ammonium ; Quaternary Ammonium Compounds - administration & dosage ; Quaternary Ammonium Compounds - chemistry ; Streptococcus ; Streptococcus mutans ; Streptococcus mutans - cytology ; Streptococcus mutans - drug effects</subject><ispartof>Biomaterials, 2006-07, Vol.27 (21), p.3995-4002</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-b16dcd59efd8631d1aaa4366daaa0aff06835b7ffdd15095f4a711bbc5f7628e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2006.03.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16564083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beyth, Nurit</creatorcontrib><creatorcontrib>Yudovin-Farber, Ira</creatorcontrib><creatorcontrib>Bahir, Ran</creatorcontrib><creatorcontrib>Domb, Abraham J.</creatorcontrib><creatorcontrib>Weiss, Ervin I.</creatorcontrib><title>Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The antibacterial activity of quaternary ammonium polyethylenimine (PEI) nanoparticles embedded at 1%
w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with
Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (
p<0.001) was found in all three types of composite resins incorporated with the synthesized nanoparticles. The effect lasted for at least 1 month. SEM demonstrated bacterial debris and no streptococcal chains at 24
h of bacterial contact. The addition of 1%
w/w of nanoparticles did not affect the flexural modulus and the flexural strength of the dental composite materials.The results indicate that quaternary ammonium PEI nanoparticles immobilized in resin-based materials have a strong antibacterial activity upon contact without leach-out of the nanoparticles and without compromise in mechanical properties.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Antibacterial</subject><subject>Cell Survival - drug effects</subject><subject>Coated Materials, Biocompatible - administration & dosage</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Composite Resins - chemistry</subject><subject>Dental composite</subject><subject>Dental Materials - chemistry</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Materials Testing</subject><subject>Nanoparticles</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>Particle Size</subject><subject>Polyethyleneimine - administration & dosage</subject><subject>Polyethyleneimine - chemistry</subject><subject>Polyethylenimine</subject><subject>Quaternary ammonium</subject><subject>Quaternary Ammonium Compounds - administration & dosage</subject><subject>Quaternary Ammonium Compounds - chemistry</subject><subject>Streptococcus</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - cytology</subject><subject>Streptococcus mutans - drug effects</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EotvCK6CIA7eEcRI7CbeqQEGqxAE4W449Ll7Fdmo7lfYFeG682pXgVk4zHn3__PL8hLyl0FCg_P2-mW1wMmO0cklNC8Ab6BqA7hnZ0XEYazYBe052QPu2njhtL8hlSnsob-jbl-SCcsZ7GLsd-X3ts52lOi2rSmMfbT5UwVQafS4jFdwaks2YSlsm1lt_Xz1sR38v46GSzgVvN1etYTlg_nVY0FtnPVZe-rDKmK1ailreF23K1fcccc1BBaW2VLktS59ekRem_AVfn-sV-fn504-bL_Xdt9uvN9d3tWLAcz1TrpVmExo98o5qKqXsO851qSCNAT52bB6M0ZoymJjp5UDpPCtmBt6O2F2Rd6e9awwPG6YsnE0Kl0V6DFsSfBgnOgJ7EmynHng575MgnSYGFHgBP5xAFUNKEY1Yo3XlgIKCOOYq9uLfXMUxVwGdKLkW8ZuzyzY71H-l5yAL8PEEYLneo8UokrLoFWobUWWhg_0fnz8w9cDw</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Beyth, Nurit</creator><creator>Yudovin-Farber, Ira</creator><creator>Bahir, Ran</creator><creator>Domb, Abraham J.</creator><creator>Weiss, Ervin I.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans</title><author>Beyth, Nurit ; 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w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with
Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (
p<0.001) was found in all three types of composite resins incorporated with the synthesized nanoparticles. The effect lasted for at least 1 month. SEM demonstrated bacterial debris and no streptococcal chains at 24
h of bacterial contact. The addition of 1%
w/w of nanoparticles did not affect the flexural modulus and the flexural strength of the dental composite materials.The results indicate that quaternary ammonium PEI nanoparticles immobilized in resin-based materials have a strong antibacterial activity upon contact without leach-out of the nanoparticles and without compromise in mechanical properties.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16564083</pmid><doi>10.1016/j.biomaterials.2006.03.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Antibacterial Cell Survival - drug effects Coated Materials, Biocompatible - administration & dosage Coated Materials, Biocompatible - chemistry Composite Resins - chemistry Dental composite Dental Materials - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Materials Testing Nanoparticles Nanostructures - chemistry Nanostructures - ultrastructure Particle Size Polyethyleneimine - administration & dosage Polyethyleneimine - chemistry Polyethylenimine Quaternary ammonium Quaternary Ammonium Compounds - administration & dosage Quaternary Ammonium Compounds - chemistry Streptococcus Streptococcus mutans Streptococcus mutans - cytology Streptococcus mutans - drug effects |
| title | Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans |
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