Is fibromyalgia a muscle disorder?
The presence of abnormalities in fibromyalgia muscle using current methodological approaches is well established. The more serious abnormalities are demonstrated by histologic studies particularly on electron microscopy: disorganisation of Z bands and abnormalities in the number and shape of mitocho...
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| Veröffentlicht in: | Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2006-05, Vol.73 (3), p.239-242 |
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| container_title | Joint, bone, spine : revue du rhumatisme |
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| creator | Le Goff, Paul |
| description | The presence of abnormalities in fibromyalgia muscle using current methodological approaches is well established. The more serious abnormalities are demonstrated by histologic studies particularly on electron microscopy: disorganisation of Z bands and abnormalities in the number and shape of mitochondria. Biochemical studies and P 31 magnetic resonance spectroscopy show inconstant abnormalities of ATP and phosphocreatine levels. Mitochondrial abnormalities reduced capillary circulation and thickened capillary endothelium may result in decreased availability of oxygen and impaired oxidative phosphorylation as well as ATP synthesis. These abnormalities do not seem to be the consequences of the much-discussed deconditioning of muscles although these consequences are not well known. Further studies of energy metabolism of the muscle during exercise are needed. |
| doi_str_mv | 10.1016/j.jbspin.2005.03.022 |
| format | Article |
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The more serious abnormalities are demonstrated by histologic studies particularly on electron microscopy: disorganisation of Z bands and abnormalities in the number and shape of mitochondria. Biochemical studies and P 31 magnetic resonance spectroscopy show inconstant abnormalities of ATP and phosphocreatine levels. Mitochondrial abnormalities reduced capillary circulation and thickened capillary endothelium may result in decreased availability of oxygen and impaired oxidative phosphorylation as well as ATP synthesis. These abnormalities do not seem to be the consequences of the much-discussed deconditioning of muscles although these consequences are not well known. Further studies of energy metabolism of the muscle during exercise are needed.</description><identifier>ISSN: 1297-319X</identifier><identifier>DOI: 10.1016/j.jbspin.2005.03.022</identifier><identifier>PMID: 16488643</identifier><language>eng</language><publisher>France: Elsevier SAS</publisher><subject>Adenosine Triphosphate - analysis ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Energy Metabolism ; Fibromyalgia ; Fibromyalgia - diagnosis ; Fibromyalgia - pathology ; Fibromyalgia - physiopathology ; Humans ; Microcirculation - physiopathology ; Microscopy, Electron ; Mitochondria, Muscle - physiology ; Mitochondria, Muscle - ultrastructure ; Muscle disease ; Muscle, Skeletal - chemistry ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Muscle, Skeletal - ultrastructure ; Muscular Diseases - diagnosis ; Muscular Diseases - pathology ; Muscular Diseases - physiopathology ; Pain ; Phosphocreatine - analysis</subject><ispartof>Joint, bone, spine : revue du rhumatisme, 2006-05, Vol.73 (3), p.239-242</ispartof><rights>2006 Elsevier SAS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-e20b8a200f313885751e4fd58d97b86942035b13910adde4423310b47d23a92a3</citedby><cites>FETCH-LOGICAL-c360t-e20b8a200f313885751e4fd58d97b86942035b13910adde4423310b47d23a92a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1297319X05001739$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16488643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Goff, Paul</creatorcontrib><title>Is fibromyalgia a muscle disorder?</title><title>Joint, bone, spine : revue du rhumatisme</title><addtitle>Joint Bone Spine</addtitle><description>The presence of abnormalities in fibromyalgia muscle using current methodological approaches is well established. 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Further studies of energy metabolism of the muscle during exercise are needed.</description><subject>Adenosine Triphosphate - analysis</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Energy Metabolism</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - diagnosis</subject><subject>Fibromyalgia - pathology</subject><subject>Fibromyalgia - physiopathology</subject><subject>Humans</subject><subject>Microcirculation - physiopathology</subject><subject>Microscopy, Electron</subject><subject>Mitochondria, Muscle - physiology</subject><subject>Mitochondria, Muscle - ultrastructure</subject><subject>Muscle disease</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscle, Skeletal - ultrastructure</subject><subject>Muscular Diseases - diagnosis</subject><subject>Muscular Diseases - pathology</subject><subject>Muscular Diseases - physiopathology</subject><subject>Pain</subject><subject>Phosphocreatine - analysis</subject><issn>1297-319X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhmeh2Fp9A5GC4C7xzCWTmY0ixUuh4EbB3TDJnMiEpKkzjdC38Vl8MlNScOfqbL7_P-d8hFxQSClQeVOndRE3fp0ygCwFngJjR2RKmc4TTvX7hJzGWAMAZ5k8IRMqhVJS8Cm5WsZ55YvQtTvbfHg7tz_fbR_LBufOxy44DHdn5LiyTcTzw5yRt8eH18Vzsnp5Wi7uV0nJJWwTZFAoO1xQccqVyvKMoqhcppzOCyW1YMCzgnJNwTqHQjDOKRQid4xbzSyfkeuxdxO6zx7j1rQ-ltg0do1dH43MlYacywEUI1iGLsaAldkE39qwMxTMXoipzSjE7IUY4GYQMsQuD_190aL7Cx1sDMDtCODw5ZfHYGLpcV2i8wHLrXGd_3_DLxhRc80</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Le Goff, Paul</creator><general>Elsevier SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Is fibromyalgia a muscle disorder?</title><author>Le Goff, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-e20b8a200f313885751e4fd58d97b86942035b13910adde4423310b47d23a92a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenosine Triphosphate - analysis</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Energy Metabolism</topic><topic>Fibromyalgia</topic><topic>Fibromyalgia - diagnosis</topic><topic>Fibromyalgia - pathology</topic><topic>Fibromyalgia - physiopathology</topic><topic>Humans</topic><topic>Microcirculation - physiopathology</topic><topic>Microscopy, Electron</topic><topic>Mitochondria, Muscle - physiology</topic><topic>Mitochondria, Muscle - ultrastructure</topic><topic>Muscle disease</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscle, Skeletal - ultrastructure</topic><topic>Muscular Diseases - diagnosis</topic><topic>Muscular Diseases - pathology</topic><topic>Muscular Diseases - physiopathology</topic><topic>Pain</topic><topic>Phosphocreatine - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Goff, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Goff, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is fibromyalgia a muscle disorder?</atitle><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle><addtitle>Joint Bone Spine</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>73</volume><issue>3</issue><spage>239</spage><epage>242</epage><pages>239-242</pages><issn>1297-319X</issn><abstract>The presence of abnormalities in fibromyalgia muscle using current methodological approaches is well established. The more serious abnormalities are demonstrated by histologic studies particularly on electron microscopy: disorganisation of Z bands and abnormalities in the number and shape of mitochondria. Biochemical studies and P 31 magnetic resonance spectroscopy show inconstant abnormalities of ATP and phosphocreatine levels. Mitochondrial abnormalities reduced capillary circulation and thickened capillary endothelium may result in decreased availability of oxygen and impaired oxidative phosphorylation as well as ATP synthesis. These abnormalities do not seem to be the consequences of the much-discussed deconditioning of muscles although these consequences are not well known. Further studies of energy metabolism of the muscle during exercise are needed.</abstract><cop>France</cop><pub>Elsevier SAS</pub><pmid>16488643</pmid><doi>10.1016/j.jbspin.2005.03.022</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1297-319X |
| ispartof | Joint, bone, spine : revue du rhumatisme, 2006-05, Vol.73 (3), p.239-242 |
| issn | 1297-319X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Triphosphate - analysis Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Energy Metabolism Fibromyalgia Fibromyalgia - diagnosis Fibromyalgia - pathology Fibromyalgia - physiopathology Humans Microcirculation - physiopathology Microscopy, Electron Mitochondria, Muscle - physiology Mitochondria, Muscle - ultrastructure Muscle disease Muscle, Skeletal - chemistry Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscle, Skeletal - ultrastructure Muscular Diseases - diagnosis Muscular Diseases - pathology Muscular Diseases - physiopathology Pain Phosphocreatine - analysis |
| title | Is fibromyalgia a muscle disorder? |
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