Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome
Aims To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. Methods and results Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The tim...
Gespeichert in:
| Veröffentlicht in: | European heart journal 2005-06, Vol.26 (12), p.1180-1187 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1187 |
|---|---|
| container_issue | 12 |
| container_start_page | 1180 |
| container_title | European heart journal |
| container_volume | 26 |
| creator | Wenaweser, Peter Rey, Christoph Eberli, Franz R. Togni, Mario Tüller, David Locher, Stefan Remondino, Andrea Seiler, Christian Hess, Otto M. Meier, Bernhard Windecker, Stephan |
| description | Aims To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. Methods and results Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thrombosis was acute in 10 (11%), subacute in 61 (64%), and late in 24 (25%) patients. Procedural and clinical outcomes of emergency PCI for treatment of stent thrombosis were investigated. Emergency PCI was successful in 86 (91%), complicated by death in 2 (2%), and coronary artery bypass grafting in 2 (2%) patients. Myocardial infarction occurred in 77 (81%) patients with a peak creatine kinase level of 1466±1570 U/L. Left ventricular ejection fraction declined from 0.54±0.19 prior to 0.48±0.16 (P |
| doi_str_mv | 10.1093/eurheartj/ehi135 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67889488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1192781781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c531t-bf68152d36b9835f9c992c9696f6eefb92fd2e45c3455c38f800a4d2b87e9f383</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhSMEokvhzglZSHALtePYa3NDC20RlRACpBUXy3HGXS-JHWyn0N_BH8Y0q1biwsVz8Pee5s2rqqcEvyJY0hOY4w50zPsT2DlC2b1qRVjT1JK37H61wkSymnOxPaoepbTHGAtO-MPqiLB1IzjDq-r35ww-o7yLYexCcgnZMAzhp_OXqNMR6hGyHlC6odw4DdpnnV3wr1GajYGUULAIRoiX4M01miCaOWsPYU7IhBi8jtfI-QzxqlgUIdK-R1OE3pkc4o1c91cQE6AwZxNGeFw9sHpI8OQwj6uvp---bM7ri49n7zdvLmrDKMl1Z7koaXvKOykos9JI2RjJJbccwHaysX0DLTO0ZeURVmCs277pxBqkpYIeVy8X3ymGHzOkrEaXDAzDsr7iayFkK_4PNhhT1q5pAZ__A-7DHH0JoRrCWtlKTgqEF8jEkFIEq6boxnImRbD6W6u6rVUttRbJs4Pv3I3Q3wkOPRbgxQHQyejBRu2NS3ccFy2Woi1cvXCuNPrr9l_H7yUtXTN1vv2mPuEtO_2wOVNv6R_2SsHq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215494961</pqid></control><display><type>article</type><title>Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome</title><source>MEDLINE</source><source>OUP_牛津大学出版社现刊</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Wenaweser, Peter ; Rey, Christoph ; Eberli, Franz R. ; Togni, Mario ; Tüller, David ; Locher, Stefan ; Remondino, Andrea ; Seiler, Christian ; Hess, Otto M. ; Meier, Bernhard ; Windecker, Stephan</creator><creatorcontrib>Wenaweser, Peter ; Rey, Christoph ; Eberli, Franz R. ; Togni, Mario ; Tüller, David ; Locher, Stefan ; Remondino, Andrea ; Seiler, Christian ; Hess, Otto M. ; Meier, Bernhard ; Windecker, Stephan</creatorcontrib><description>Aims To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. Methods and results Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thrombosis was acute in 10 (11%), subacute in 61 (64%), and late in 24 (25%) patients. Procedural and clinical outcomes of emergency PCI for treatment of stent thrombosis were investigated. Emergency PCI was successful in 86 (91%), complicated by death in 2 (2%), and coronary artery bypass grafting in 2 (2%) patients. Myocardial infarction occurred in 77 (81%) patients with a peak creatine kinase level of 1466±1570 U/L. Left ventricular ejection fraction declined from 0.54±0.19 prior to 0.48±0.16 (P<0.05) at the time of stent thrombosis after emergency PCI. A 6 month major adverse clinical events comprised death (11%), reinfarction (16%), and recurrent stent thrombosis (12%) after emergency PCI. Multivariable logistic regression analysis identified the achievement of TIMI 3 flow (OR=0.1, CI 95% 0.01–0.54, P<0.001) and diameter stenosis <50% (OR=0.06, CI 95% 0.01–0.32, P<0.001) during emergency PCI to be independently associated with a reduced risk of cardiac death. Recurrent stent thrombosis was independently predicted by the omission of abciximab (OR=4.3, CI 95% 1.1–17.5). Conclusion Emergency PCI for treatment of stent thrombosis effectively restores vessel patency and flow. Patients presenting with stent thrombosis are at risk for recurrent myocardial infarction and recurrent stent thrombosis.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehi135</identifier><identifier>PMID: 15728650</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Angioplasty, Balloon, Coronary - methods ; Antibodies, Monoclonal - therapeutic use ; Biological and medical sciences ; Blood Vessel Prosthesis ; Cardiology. Vascular system ; Death, Sudden, Cardiac - prevention & control ; Emergency Treatment - methods ; Female ; Follow-Up Studies ; Graft Occlusion, Vascular - therapy ; Humans ; Immunoglobulin Fab Fragments - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Platelet Aggregation Inhibitors - therapeutic use ; Secondary Prevention ; Stent ; Stents - adverse effects ; Survival Analysis ; Thrombosis ; Thrombosis - etiology ; Thrombosis - therapy ; Treatment Outcome ; Tyrosine - analogs & derivatives ; Tyrosine - therapeutic use</subject><ispartof>European heart journal, 2005-06, Vol.26 (12), p.1180-1187</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jun 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-bf68152d36b9835f9c992c9696f6eefb92fd2e45c3455c38f800a4d2b87e9f383</citedby><cites>FETCH-LOGICAL-c531t-bf68152d36b9835f9c992c9696f6eefb92fd2e45c3455c38f800a4d2b87e9f383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16840984$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15728650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wenaweser, Peter</creatorcontrib><creatorcontrib>Rey, Christoph</creatorcontrib><creatorcontrib>Eberli, Franz R.</creatorcontrib><creatorcontrib>Togni, Mario</creatorcontrib><creatorcontrib>Tüller, David</creatorcontrib><creatorcontrib>Locher, Stefan</creatorcontrib><creatorcontrib>Remondino, Andrea</creatorcontrib><creatorcontrib>Seiler, Christian</creatorcontrib><creatorcontrib>Hess, Otto M.</creatorcontrib><creatorcontrib>Meier, Bernhard</creatorcontrib><creatorcontrib>Windecker, Stephan</creatorcontrib><title>Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. Methods and results Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thrombosis was acute in 10 (11%), subacute in 61 (64%), and late in 24 (25%) patients. Procedural and clinical outcomes of emergency PCI for treatment of stent thrombosis were investigated. Emergency PCI was successful in 86 (91%), complicated by death in 2 (2%), and coronary artery bypass grafting in 2 (2%) patients. Myocardial infarction occurred in 77 (81%) patients with a peak creatine kinase level of 1466±1570 U/L. Left ventricular ejection fraction declined from 0.54±0.19 prior to 0.48±0.16 (P<0.05) at the time of stent thrombosis after emergency PCI. A 6 month major adverse clinical events comprised death (11%), reinfarction (16%), and recurrent stent thrombosis (12%) after emergency PCI. Multivariable logistic regression analysis identified the achievement of TIMI 3 flow (OR=0.1, CI 95% 0.01–0.54, P<0.001) and diameter stenosis <50% (OR=0.06, CI 95% 0.01–0.32, P<0.001) during emergency PCI to be independently associated with a reduced risk of cardiac death. Recurrent stent thrombosis was independently predicted by the omission of abciximab (OR=4.3, CI 95% 1.1–17.5). Conclusion Emergency PCI for treatment of stent thrombosis effectively restores vessel patency and flow. Patients presenting with stent thrombosis are at risk for recurrent myocardial infarction and recurrent stent thrombosis.</description><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis</subject><subject>Cardiology. Vascular system</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Emergency Treatment - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft Occlusion, Vascular - therapy</subject><subject>Humans</subject><subject>Immunoglobulin Fab Fragments - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Secondary Prevention</subject><subject>Stent</subject><subject>Stents - adverse effects</subject><subject>Survival Analysis</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - therapy</subject><subject>Treatment Outcome</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - therapeutic use</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEokvhzglZSHALtePYa3NDC20RlRACpBUXy3HGXS-JHWyn0N_BH8Y0q1biwsVz8Pee5s2rqqcEvyJY0hOY4w50zPsT2DlC2b1qRVjT1JK37H61wkSymnOxPaoepbTHGAtO-MPqiLB1IzjDq-r35ww-o7yLYexCcgnZMAzhp_OXqNMR6hGyHlC6odw4DdpnnV3wr1GajYGUULAIRoiX4M01miCaOWsPYU7IhBi8jtfI-QzxqlgUIdK-R1OE3pkc4o1c91cQE6AwZxNGeFw9sHpI8OQwj6uvp---bM7ri49n7zdvLmrDKMl1Z7koaXvKOykos9JI2RjJJbccwHaysX0DLTO0ZeURVmCs277pxBqkpYIeVy8X3ymGHzOkrEaXDAzDsr7iayFkK_4PNhhT1q5pAZ__A-7DHH0JoRrCWtlKTgqEF8jEkFIEq6boxnImRbD6W6u6rVUttRbJs4Pv3I3Q3wkOPRbgxQHQyejBRu2NS3ccFy2Woi1cvXCuNPrr9l_H7yUtXTN1vv2mPuEtO_2wOVNv6R_2SsHq</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Wenaweser, Peter</creator><creator>Rey, Christoph</creator><creator>Eberli, Franz R.</creator><creator>Togni, Mario</creator><creator>Tüller, David</creator><creator>Locher, Stefan</creator><creator>Remondino, Andrea</creator><creator>Seiler, Christian</creator><creator>Hess, Otto M.</creator><creator>Meier, Bernhard</creator><creator>Windecker, Stephan</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome</title><author>Wenaweser, Peter ; Rey, Christoph ; Eberli, Franz R. ; Togni, Mario ; Tüller, David ; Locher, Stefan ; Remondino, Andrea ; Seiler, Christian ; Hess, Otto M. ; Meier, Bernhard ; Windecker, Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-bf68152d36b9835f9c992c9696f6eefb92fd2e45c3455c38f800a4d2b87e9f383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Vessel Prosthesis</topic><topic>Cardiology. Vascular system</topic><topic>Death, Sudden, Cardiac - prevention & control</topic><topic>Emergency Treatment - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft Occlusion, Vascular - therapy</topic><topic>Humans</topic><topic>Immunoglobulin Fab Fragments - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Secondary Prevention</topic><topic>Stent</topic><topic>Stents - adverse effects</topic><topic>Survival Analysis</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - therapy</topic><topic>Treatment Outcome</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wenaweser, Peter</creatorcontrib><creatorcontrib>Rey, Christoph</creatorcontrib><creatorcontrib>Eberli, Franz R.</creatorcontrib><creatorcontrib>Togni, Mario</creatorcontrib><creatorcontrib>Tüller, David</creatorcontrib><creatorcontrib>Locher, Stefan</creatorcontrib><creatorcontrib>Remondino, Andrea</creatorcontrib><creatorcontrib>Seiler, Christian</creatorcontrib><creatorcontrib>Hess, Otto M.</creatorcontrib><creatorcontrib>Meier, Bernhard</creatorcontrib><creatorcontrib>Windecker, Stephan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wenaweser, Peter</au><au>Rey, Christoph</au><au>Eberli, Franz R.</au><au>Togni, Mario</au><au>Tüller, David</au><au>Locher, Stefan</au><au>Remondino, Andrea</au><au>Seiler, Christian</au><au>Hess, Otto M.</au><au>Meier, Bernhard</au><au>Windecker, Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>26</volume><issue>12</issue><spage>1180</spage><epage>1187</epage><pages>1180-1187</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. Methods and results Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thrombosis was acute in 10 (11%), subacute in 61 (64%), and late in 24 (25%) patients. Procedural and clinical outcomes of emergency PCI for treatment of stent thrombosis were investigated. Emergency PCI was successful in 86 (91%), complicated by death in 2 (2%), and coronary artery bypass grafting in 2 (2%) patients. Myocardial infarction occurred in 77 (81%) patients with a peak creatine kinase level of 1466±1570 U/L. Left ventricular ejection fraction declined from 0.54±0.19 prior to 0.48±0.16 (P<0.05) at the time of stent thrombosis after emergency PCI. A 6 month major adverse clinical events comprised death (11%), reinfarction (16%), and recurrent stent thrombosis (12%) after emergency PCI. Multivariable logistic regression analysis identified the achievement of TIMI 3 flow (OR=0.1, CI 95% 0.01–0.54, P<0.001) and diameter stenosis <50% (OR=0.06, CI 95% 0.01–0.32, P<0.001) during emergency PCI to be independently associated with a reduced risk of cardiac death. Recurrent stent thrombosis was independently predicted by the omission of abciximab (OR=4.3, CI 95% 1.1–17.5). Conclusion Emergency PCI for treatment of stent thrombosis effectively restores vessel patency and flow. Patients presenting with stent thrombosis are at risk for recurrent myocardial infarction and recurrent stent thrombosis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15728650</pmid><doi>10.1093/eurheartj/ehi135</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 2005-06, Vol.26 (12), p.1180-1187 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67889488 |
| source | MEDLINE; OUP_牛津大学出版社现刊; Free E-Journal (出版社公開部分のみ） |
| subjects | Angioplasty, Balloon, Coronary - methods Antibodies, Monoclonal - therapeutic use Biological and medical sciences Blood Vessel Prosthesis Cardiology. Vascular system Death, Sudden, Cardiac - prevention & control Emergency Treatment - methods Female Follow-Up Studies Graft Occlusion, Vascular - therapy Humans Immunoglobulin Fab Fragments - therapeutic use Male Medical sciences Middle Aged Platelet Aggregation Inhibitors - therapeutic use Secondary Prevention Stent Stents - adverse effects Survival Analysis Thrombosis Thrombosis - etiology Thrombosis - therapy Treatment Outcome Tyrosine - analogs & derivatives Tyrosine - therapeutic use |
| title | Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A22%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stent%20thrombosis%20following%20bare-metal%20stent%20implantation:%20success%20of%20emergency%20percutaneous%20coronary%20intervention%20and%20predictors%20of%20adverse%20outcome&rft.jtitle=European%20heart%20journal&rft.au=Wenaweser,%20Peter&rft.date=2005-06-01&rft.volume=26&rft.issue=12&rft.spage=1180&rft.epage=1187&rft.pages=1180-1187&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/eurheartj/ehi135&rft_dat=%3Cproquest_cross%3E1192781781%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=215494961&rft_id=info:pmid/15728650&rfr_iscdi=true |