Antihypertensive Potential and Mechanism of Action of Astaxanthin: II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats
The current study was designed to determine the effects of a dietary astaxanthin (ASX-O) on vascular reactivity in spontaneously hypertensive rats (SHR), in order to verify its antihypertensive action mechanism. We evaluated contractions induced by phenylephrine (Phe), angiotensin II (Ang II) and th...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2005, Vol.28(6), pp.967-971 |
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| creator | Hussein, Ghazi Goto, Hirozo Oda, Shinobu Iguchi, Tomomi Sankawa, Ushio Matsumoto, Kinzo Watanabe, Hiroshi |
| description | The current study was designed to determine the effects of a dietary astaxanthin (ASX-O) on vascular reactivity in spontaneously hypertensive rats (SHR), in order to verify its antihypertensive action mechanism. We evaluated contractions induced by phenylephrine (Phe), angiotensin II (Ang II) and the xanthine/xanthine oxidase (Xan/XOD) system, and relaxations induced by sodium nitroprusside (SNP) as well as endothelium-dependent relaxations mediated by acetylcholine (ACh) in thoracic aorta of the SHR, with and without ASX-O intervention. We also investigated the effects of ASX-O on blood rheology using a microchannel array system. In this study, ASX-O showed a significant modulatory effect on nitric oxide (NO)-induced vasorelaxation by the NO-donor SNP (p |
| doi_str_mv | 10.1248/bpb.28.967 |
| format | Article |
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Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Hussein, Ghazi ; Goto, Hirozo ; Oda, Shinobu ; Iguchi, Tomomi ; Sankawa, Ushio ; Matsumoto, Kinzo ; Watanabe, Hiroshi</creator><creatorcontrib>Hussein, Ghazi ; Goto, Hirozo ; Oda, Shinobu ; Iguchi, Tomomi ; Sankawa, Ushio ; Matsumoto, Kinzo ; Watanabe, Hiroshi ; Toyama Prefecture ; bDivision of Medicinal Pharmacology ; Toyama Medical & Pharmaceutical University ; aInternational Research Center for Traditional Medicine ; cDepartment of Kampo Diagnostics ; Institute of Natural Medicine</creatorcontrib><description>The current study was designed to determine the effects of a dietary astaxanthin (ASX-O) on vascular reactivity in spontaneously hypertensive rats (SHR), in order to verify its antihypertensive action mechanism. We evaluated contractions induced by phenylephrine (Phe), angiotensin II (Ang II) and the xanthine/xanthine oxidase (Xan/XOD) system, and relaxations induced by sodium nitroprusside (SNP) as well as endothelium-dependent relaxations mediated by acetylcholine (ACh) in thoracic aorta of the SHR, with and without ASX-O intervention. We also investigated the effects of ASX-O on blood rheology using a microchannel array system. In this study, ASX-O showed a significant modulatory effect on nitric oxide (NO)-induced vasorelaxation by the NO-donor SNP (p<0.05). However, it did not show significant effects in restoring the impaired endothelium-dependent relaxation to ACh in the SHR. On the other hand, the constrictive effects by Phe, Ang II and Xan/XOD were ameliorated by ASX-O (p<0.05). ASX-O also demonstrated significant hemorheological effect by decreasing the microchannel transit time of whole blood. In conclusion, the results suggest that ASX-O may act in modulating the blood fluidity in hypertension, and that the antihypertensive effects of ASX-O may be exerted through mechanisms including normalization of the sensitivity of the adrenoceptor sympathetic pathway, particularly [alpha]-adrenoceptors, and by restoration of the vascular tone through attenuation of the Ang II- and reactive oxygen species (ROS)-induced vasoconstriction.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.28.967</identifier><identifier>PMID: 15930728</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antihypertensive Agents - pharmacology ; Antihypertensive Agents - therapeutic use ; Aorta - drug effects ; Aorta - physiology ; astaxanthin ; beta Carotene - analogs & derivatives ; beta Carotene - pharmacology ; beta Carotene - therapeutic use ; blood rheology ; Hemorheology - methods ; hypertension ; Hypertension - drug therapy ; Hypertension - physiopathology ; In Vitro Techniques ; Male ; mechanism ; Rats ; Rats, Inbred SHR ; Vasoconstriction - drug effects ; Vasoconstriction - physiology ; Vasodilation - drug effects ; Vasodilation - physiology ; vasorelaxation ; Xanthophylls</subject><ispartof>Biological and Pharmaceutical Bulletin, 2005, Vol.28(6), pp.967-971</ispartof><rights>2005 The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-92dfb5d54bc7e2a824618ee6829708b1970e594cdc348479de2c8896622f22793</citedby><cites>FETCH-LOGICAL-c542t-92dfb5d54bc7e2a824618ee6829708b1970e594cdc348479de2c8896622f22793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15930728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussein, Ghazi</creatorcontrib><creatorcontrib>Goto, Hirozo</creatorcontrib><creatorcontrib>Oda, Shinobu</creatorcontrib><creatorcontrib>Iguchi, Tomomi</creatorcontrib><creatorcontrib>Sankawa, Ushio</creatorcontrib><creatorcontrib>Matsumoto, Kinzo</creatorcontrib><creatorcontrib>Watanabe, Hiroshi</creatorcontrib><creatorcontrib>Toyama Prefecture</creatorcontrib><creatorcontrib>bDivision of Medicinal Pharmacology</creatorcontrib><creatorcontrib>Toyama Medical & Pharmaceutical University</creatorcontrib><creatorcontrib>aInternational Research Center for Traditional Medicine</creatorcontrib><creatorcontrib>cDepartment of Kampo Diagnostics</creatorcontrib><creatorcontrib>Institute of Natural Medicine</creatorcontrib><title>Antihypertensive Potential and Mechanism of Action of Astaxanthin: II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The current study was designed to determine the effects of a dietary astaxanthin (ASX-O) on vascular reactivity in spontaneously hypertensive rats (SHR), in order to verify its antihypertensive action mechanism. We evaluated contractions induced by phenylephrine (Phe), angiotensin II (Ang II) and the xanthine/xanthine oxidase (Xan/XOD) system, and relaxations induced by sodium nitroprusside (SNP) as well as endothelium-dependent relaxations mediated by acetylcholine (ACh) in thoracic aorta of the SHR, with and without ASX-O intervention. We also investigated the effects of ASX-O on blood rheology using a microchannel array system. In this study, ASX-O showed a significant modulatory effect on nitric oxide (NO)-induced vasorelaxation by the NO-donor SNP (p<0.05). However, it did not show significant effects in restoring the impaired endothelium-dependent relaxation to ACh in the SHR. On the other hand, the constrictive effects by Phe, Ang II and Xan/XOD were ameliorated by ASX-O (p<0.05). ASX-O also demonstrated significant hemorheological effect by decreasing the microchannel transit time of whole blood. In conclusion, the results suggest that ASX-O may act in modulating the blood fluidity in hypertension, and that the antihypertensive effects of ASX-O may be exerted through mechanisms including normalization of the sensitivity of the adrenoceptor sympathetic pathway, particularly [alpha]-adrenoceptors, and by restoration of the vascular tone through attenuation of the Ang II- and reactive oxygen species (ROS)-induced vasoconstriction.</description><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Aorta - drug effects</subject><subject>Aorta - physiology</subject><subject>astaxanthin</subject><subject>beta Carotene - analogs & derivatives</subject><subject>beta Carotene - pharmacology</subject><subject>beta Carotene - therapeutic use</subject><subject>blood rheology</subject><subject>Hemorheology - methods</subject><subject>hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>mechanism</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstriction - physiology</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><subject>vasorelaxation</subject><subject>Xanthophylls</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU1v1DAQhiMEotvChR-AfOKAlMV2PuxwQauKdlcqApWPq-U4k65Xjh1spyJ_gt-Mt9kCB49HmsfvjN_JslcErwkt-bt2bNeUr5uaPclWpChZXlFSPc1WuCE8r0nFz7LzEA4YY4Zp8Tw7I1VTYEb5Kvu9sVHv5xF8BBv0PaAvLmVRS4Ok7dAnUHtpdRiQ69FGRe3sQxai_CVt3Gv7Hu12a_RDBjUZ6dEtyETd6zg_vN_C4PwenHF3M9IWfR2djdKCm4KZ0fb_xrcyhhfZs16aAC9P90X2_erjt8ttfvP5ene5uclVVdKYN7Tr26qrylYxoJLTsiYcoOa0YZi3JEWomlJ1qih5yZoOqOK8qWtKe0pZU1xkbxbd0bufE4QoBh0UGLOMJmqW8KLECXy7gMq7EDz0YvR6kH4WBIuj-yK5LygXyf0Evz6pTu0A3T_0ZHcCrhcgVbWSxlmjLYiDm7xN3xUqsFYnrwTFuBIYU47rdKWT5FNghGDGKDsqfViUDmkTd_C3lfRRKwOPU9VLOL5-rKR9egG2-APzK6-i</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Hussein, Ghazi</creator><creator>Goto, Hirozo</creator><creator>Oda, Shinobu</creator><creator>Iguchi, Tomomi</creator><creator>Sankawa, Ushio</creator><creator>Matsumoto, Kinzo</creator><creator>Watanabe, Hiroshi</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Antihypertensive Potential and Mechanism of Action of Astaxanthin: II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats</title><author>Hussein, Ghazi ; Goto, Hirozo ; Oda, Shinobu ; Iguchi, Tomomi ; Sankawa, Ushio ; Matsumoto, Kinzo ; Watanabe, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-92dfb5d54bc7e2a824618ee6829708b1970e594cdc348479de2c8896622f22793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Aorta - drug effects</topic><topic>Aorta - physiology</topic><topic>astaxanthin</topic><topic>beta Carotene - analogs & derivatives</topic><topic>beta Carotene - pharmacology</topic><topic>beta Carotene - therapeutic use</topic><topic>blood rheology</topic><topic>Hemorheology - methods</topic><topic>hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>mechanism</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstriction - physiology</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>vasorelaxation</topic><topic>Xanthophylls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussein, Ghazi</creatorcontrib><creatorcontrib>Goto, Hirozo</creatorcontrib><creatorcontrib>Oda, Shinobu</creatorcontrib><creatorcontrib>Iguchi, Tomomi</creatorcontrib><creatorcontrib>Sankawa, Ushio</creatorcontrib><creatorcontrib>Matsumoto, Kinzo</creatorcontrib><creatorcontrib>Watanabe, Hiroshi</creatorcontrib><creatorcontrib>Toyama Prefecture</creatorcontrib><creatorcontrib>bDivision of Medicinal Pharmacology</creatorcontrib><creatorcontrib>Toyama Medical & Pharmaceutical University</creatorcontrib><creatorcontrib>aInternational Research Center for Traditional Medicine</creatorcontrib><creatorcontrib>cDepartment of Kampo Diagnostics</creatorcontrib><creatorcontrib>Institute of Natural Medicine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussein, Ghazi</au><au>Goto, Hirozo</au><au>Oda, Shinobu</au><au>Iguchi, Tomomi</au><au>Sankawa, Ushio</au><au>Matsumoto, Kinzo</au><au>Watanabe, Hiroshi</au><aucorp>Toyama Prefecture</aucorp><aucorp>bDivision of Medicinal Pharmacology</aucorp><aucorp>Toyama Medical & Pharmaceutical University</aucorp><aucorp>aInternational Research Center for Traditional Medicine</aucorp><aucorp>cDepartment of Kampo Diagnostics</aucorp><aucorp>Institute of Natural Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihypertensive Potential and Mechanism of Action of Astaxanthin: II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2005</date><risdate>2005</risdate><volume>28</volume><issue>6</issue><spage>967</spage><epage>971</epage><pages>967-971</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The current study was designed to determine the effects of a dietary astaxanthin (ASX-O) on vascular reactivity in spontaneously hypertensive rats (SHR), in order to verify its antihypertensive action mechanism. We evaluated contractions induced by phenylephrine (Phe), angiotensin II (Ang II) and the xanthine/xanthine oxidase (Xan/XOD) system, and relaxations induced by sodium nitroprusside (SNP) as well as endothelium-dependent relaxations mediated by acetylcholine (ACh) in thoracic aorta of the SHR, with and without ASX-O intervention. We also investigated the effects of ASX-O on blood rheology using a microchannel array system. In this study, ASX-O showed a significant modulatory effect on nitric oxide (NO)-induced vasorelaxation by the NO-donor SNP (p<0.05). However, it did not show significant effects in restoring the impaired endothelium-dependent relaxation to ACh in the SHR. On the other hand, the constrictive effects by Phe, Ang II and Xan/XOD were ameliorated by ASX-O (p<0.05). ASX-O also demonstrated significant hemorheological effect by decreasing the microchannel transit time of whole blood. In conclusion, the results suggest that ASX-O may act in modulating the blood fluidity in hypertension, and that the antihypertensive effects of ASX-O may be exerted through mechanisms including normalization of the sensitivity of the adrenoceptor sympathetic pathway, particularly [alpha]-adrenoceptors, and by restoration of the vascular tone through attenuation of the Ang II- and reactive oxygen species (ROS)-induced vasoconstriction.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>15930728</pmid><doi>10.1248/bpb.28.967</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Aorta - drug effects Aorta - physiology astaxanthin beta Carotene - analogs & derivatives beta Carotene - pharmacology beta Carotene - therapeutic use blood rheology Hemorheology - methods hypertension Hypertension - drug therapy Hypertension - physiopathology In Vitro Techniques Male mechanism Rats Rats, Inbred SHR Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilation - drug effects Vasodilation - physiology vasorelaxation Xanthophylls |
| title | Antihypertensive Potential and Mechanism of Action of Astaxanthin: II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats |
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