G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits
Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were t...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2006-05, Vol.344 (1), p.370-376 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Hasegawa, Hiroshi Takano, Hiroyuki Ohtsuka, Masashi Ueda, Kazutaka Niitsuma, Yuriko Qin, Yingjie Tadokoro, Hiroyuki Shiomi, Masashi Komuro, Issei |
| description | Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis. |
| doi_str_mv | 10.1016/j.bbrc.2006.03.081 |
| format | Article |
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We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2006.03.081</identifier><identifier>PMID: 16600176</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Atherosclerosis ; Coronary Artery Disease - drug therapy ; Cytokine ; Disease Models, Animal ; G-CSF ; Granulocyte Colony-Stimulating Factor - therapeutic use ; Lipids - blood ; Myocardial Infarction - prevention & control ; Rabbits - metabolism ; Tunica Intima - drug effects ; Tunica Intima - pathology ; Vascular injury ; WHHL-MI</subject><ispartof>Biochemical and biophysical research communications, 2006-05, Vol.344 (1), p.370-376</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-2319a8ec31946d283110cca496435db2742a30d9c570448353ecf5fced5bbdec3</citedby><cites>FETCH-LOGICAL-c420t-2319a8ec31946d283110cca496435db2742a30d9c570448353ecf5fced5bbdec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X06006048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16600176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Hiroshi</creatorcontrib><creatorcontrib>Takano, Hiroyuki</creatorcontrib><creatorcontrib>Ohtsuka, Masashi</creatorcontrib><creatorcontrib>Ueda, Kazutaka</creatorcontrib><creatorcontrib>Niitsuma, Yuriko</creatorcontrib><creatorcontrib>Qin, Yingjie</creatorcontrib><creatorcontrib>Tadokoro, Hiroyuki</creatorcontrib><creatorcontrib>Shiomi, Masashi</creatorcontrib><creatorcontrib>Komuro, Issei</creatorcontrib><title>G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis.</description><subject>Animals</subject><subject>Atherosclerosis</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Cytokine</subject><subject>Disease Models, Animal</subject><subject>G-CSF</subject><subject>Granulocyte Colony-Stimulating Factor - therapeutic use</subject><subject>Lipids - blood</subject><subject>Myocardial Infarction - prevention & control</subject><subject>Rabbits - metabolism</subject><subject>Tunica Intima - drug effects</subject><subject>Tunica Intima - pathology</subject><subject>Vascular injury</subject><subject>WHHL-MI</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UE1Lw0AQXUSxtfoHPEhO3hJnP7JJwIsUW4WCBy14Wza7E92SJrqbFvz3bmjBm5cZZua9x5tHyDWFjAKVd5usrr3JGIDMgGdQ0hMypVBByiiIUzKFeElZRd8n5CKEDQClQlbnZEKljEMhp2S9TOevi-TL4x67ISTDJ8ah__AYguu7pG8SHXe-D6YdqwuJ7mzSYe-6wW11mzS93-phxLou8bqu3RAuyVmj24BXxz4j68Xj2_wpXb0sn-cPq9QIBkPKOK10iSY2IS0rOaVgjBaVFDy3NSsE0xxsZfIChCh5ztE0eWPQ5nVtI29Gbg-60fL3DsOgti4YbFsdDe6CkkVZFkXkzQg7AE38IXhs1JeP7v2PoqDGMNVGjWGqMUwFXMUwI-nmqL6rt2j_KMf0IuD-AMD4496hV8E47KI_59EMyvbuP_1fsKaGPw</recordid><startdate>20060526</startdate><enddate>20060526</enddate><creator>Hasegawa, Hiroshi</creator><creator>Takano, Hiroyuki</creator><creator>Ohtsuka, Masashi</creator><creator>Ueda, Kazutaka</creator><creator>Niitsuma, Yuriko</creator><creator>Qin, Yingjie</creator><creator>Tadokoro, Hiroyuki</creator><creator>Shiomi, Masashi</creator><creator>Komuro, Issei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060526</creationdate><title>G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits</title><author>Hasegawa, Hiroshi ; Takano, Hiroyuki ; Ohtsuka, Masashi ; Ueda, Kazutaka ; Niitsuma, Yuriko ; Qin, Yingjie ; Tadokoro, Hiroyuki ; Shiomi, Masashi ; Komuro, Issei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-2319a8ec31946d283110cca496435db2742a30d9c570448353ecf5fced5bbdec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Atherosclerosis</topic><topic>Coronary Artery Disease - drug therapy</topic><topic>Cytokine</topic><topic>Disease Models, Animal</topic><topic>G-CSF</topic><topic>Granulocyte Colony-Stimulating Factor - therapeutic use</topic><topic>Lipids - blood</topic><topic>Myocardial Infarction - prevention & control</topic><topic>Rabbits - metabolism</topic><topic>Tunica Intima - drug effects</topic><topic>Tunica Intima - pathology</topic><topic>Vascular injury</topic><topic>WHHL-MI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Hiroshi</creatorcontrib><creatorcontrib>Takano, Hiroyuki</creatorcontrib><creatorcontrib>Ohtsuka, Masashi</creatorcontrib><creatorcontrib>Ueda, Kazutaka</creatorcontrib><creatorcontrib>Niitsuma, Yuriko</creatorcontrib><creatorcontrib>Qin, Yingjie</creatorcontrib><creatorcontrib>Tadokoro, Hiroyuki</creatorcontrib><creatorcontrib>Shiomi, Masashi</creatorcontrib><creatorcontrib>Komuro, Issei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Hiroshi</au><au>Takano, Hiroyuki</au><au>Ohtsuka, Masashi</au><au>Ueda, Kazutaka</au><au>Niitsuma, Yuriko</au><au>Qin, Yingjie</au><au>Tadokoro, Hiroyuki</au><au>Shiomi, Masashi</au><au>Komuro, Issei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-05-26</date><risdate>2006</risdate><volume>344</volume><issue>1</issue><spage>370</spage><epage>376</epage><pages>370-376</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling after myocardial infarction, but its effect on atherosclerosis is unknown. We examined two kinds of rabbit atherosclerosis models. Myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits were treated with G-CSF or saline for 7 days from 14 months old. The vascular injury models were created by inflating angioplasty balloon in the iliac artery of rabbits and were divided into G-CSF and saline group. G-CSF significantly reduced the stenosis score of coronary artery and lipid plaque area of thoracic aorta in WHHL-MI rabbits at 4 weeks after the treatment. In the vascular injury model, G-CSF significantly prevented an increase in neointima/media ratio at 4 weeks after the treatment. G-CSF accelerated the reendothelialization of denuded arteries, and the pretreatment with nitric oxide synthase inhibitor significantly inhibited it. These results suggest that G-CSF has a therapeutic potential for the progression of atherosclerosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16600176</pmid><doi>10.1016/j.bbrc.2006.03.081</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Atherosclerosis Coronary Artery Disease - drug therapy Cytokine Disease Models, Animal G-CSF Granulocyte Colony-Stimulating Factor - therapeutic use Lipids - blood Myocardial Infarction - prevention & control Rabbits - metabolism Tunica Intima - drug effects Tunica Intima - pathology Vascular injury WHHL-MI |
| title | G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits |
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