Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction

OBJECTIVE:To examine the association between decreased release of proinflammatory cytokines in response to urinary trypsin inhibitor pretreatment and decreased myocardial and lung injury after cardiopulmonary bypass. DESIGN:A prospective, randomized, double-blind study. SETTING:University hospital....

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Veröffentlicht in:	Critical care medicine 2006-05, Vol.34 (5), p.1351-1357
Hauptverfasser:	Nakanishi, Kazuhiro, Takeda, Shinhiro, Sakamoto, Atsuhiro, Kitamura, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiopulmonary Bypass - adverse effects Coronary Artery Bypass Cytokines - blood Cytokines - drug effects Double-Blind Method Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Female Glycoproteins - pharmacology Glycoproteins - therapeutic use Hemodynamics - drug effects Humans Intensive care medicine Leukocyte Elastase - blood Leukocyte Elastase - drug effects Male Medical sciences Middle Aged Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - prevention & control Pneumology Prospective Studies Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - prevention & control Troponin T - blood Troponin T - drug effects Trypsin Inhibitors - pharmacology Trypsin Inhibitors - therapeutic use
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