ferritin light-chain homologue promoter in Aedes aegypti
Promoters that direct the expression of antipathogenic molecules to primary sites of pathogenic invasions provide a means to interfere with these invasions. Thus, they have the potential to be used in mosquito control. However, exogenous elements are known to lower the fitness of most insects, and g...
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| Veröffentlicht in: | Insect molecular biology 2005-06, Vol.14 (3), p.263-270 |
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| creator | Pham, D.Q.D Chavez, C.A |
| description | Promoters that direct the expression of antipathogenic molecules to primary sites of pathogenic invasions provide a means to interfere with these invasions. Thus, they have the potential to be used in mosquito control. However, exogenous elements are known to lower the fitness of most insects, and given the ability of insects to evolve rapidly, all currently known promoters could be rendered useless. As transgenic mosquitoes may be a major component in the fight against mosquito‐borne diseases, the identification of new mosquito promoters is needed. The promoter of the Aedes aegypti ferritin light‐chain homologue (LCH) gene, a gene whose expression is induced in gut tissues during blood feeding has been identified and mapped. Transfection data indicate that the ferritin LCH promoter is a strong promoter. DNase I footprinting data and Transfac analyses suggest that the ferritin LCH promoter contains putative GATA, E2F, NIT2, TATA and DPE sites. These data together provide the first detailed map of a known ferritin LCH gene. |
| doi_str_mv | 10.1111/j.1365-2583.2005.00556.x |
| format | Article |
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These data together provide the first detailed map of a known ferritin LCH gene.</description><identifier>ISSN: 0962-1075</identifier><identifier>EISSN: 1365-2583</identifier><identifier>DOI: 10.1111/j.1365-2583.2005.00556.x</identifier><identifier>PMID: 15926895</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aedes - genetics ; Aedes aegypti ; Animals ; Base Sequence ; Cells, Cultured ; chromosome mapping ; Culicidae ; DNA footprinting ; ferritin ; ferritin light-chain homologue promoter ; Ferritins - genetics ; gene expression regulation ; gene regulation ; hematophagy ; Insect Proteins - genetics ; iron ; Iron - physiology ; Molecular Sequence Data ; mosquito ; promoter regions ; Promoter Regions, Genetic - genetics ; Promoter Regions, Genetic - physiology ; protein subunits ; regulatory sequences ; Regulatory Sequences, Nucleic Acid ; transcription ; transcription (genetics) ; Transcription, Genetic - physiology ; transfection</subject><ispartof>Insect molecular biology, 2005-06, Vol.14 (3), p.263-270</ispartof><rights>2005 The Royal Entomological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4866-c6c1e5d158e477b8ceca70b6a628dc19d6f11d69560ea8007a50232a30a2e473</citedby><cites>FETCH-LOGICAL-c4866-c6c1e5d158e477b8ceca70b6a628dc19d6f11d69560ea8007a50232a30a2e473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2583.2005.00556.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2583.2005.00556.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15926895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pham, D.Q.D</creatorcontrib><creatorcontrib>Chavez, C.A</creatorcontrib><title>ferritin light-chain homologue promoter in Aedes aegypti</title><title>Insect molecular biology</title><addtitle>Insect Mol Biol</addtitle><description>Promoters that direct the expression of antipathogenic molecules to primary sites of pathogenic invasions provide a means to interfere with these invasions. Thus, they have the potential to be used in mosquito control. However, exogenous elements are known to lower the fitness of most insects, and given the ability of insects to evolve rapidly, all currently known promoters could be rendered useless. As transgenic mosquitoes may be a major component in the fight against mosquito‐borne diseases, the identification of new mosquito promoters is needed. The promoter of the Aedes aegypti ferritin light‐chain homologue (LCH) gene, a gene whose expression is induced in gut tissues during blood feeding has been identified and mapped. Transfection data indicate that the ferritin LCH promoter is a strong promoter. DNase I footprinting data and Transfac analyses suggest that the ferritin LCH promoter contains putative GATA, E2F, NIT2, TATA and DPE sites. These data together provide the first detailed map of a known ferritin LCH gene.</description><subject>Aedes - genetics</subject><subject>Aedes aegypti</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cells, Cultured</subject><subject>chromosome mapping</subject><subject>Culicidae</subject><subject>DNA footprinting</subject><subject>ferritin</subject><subject>ferritin light-chain homologue promoter</subject><subject>Ferritins - genetics</subject><subject>gene expression regulation</subject><subject>gene regulation</subject><subject>hematophagy</subject><subject>Insect Proteins - genetics</subject><subject>iron</subject><subject>Iron - physiology</subject><subject>Molecular Sequence Data</subject><subject>mosquito</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Promoter Regions, Genetic - physiology</subject><subject>protein subunits</subject><subject>regulatory sequences</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>transcription</subject><subject>transcription (genetics)</subject><subject>Transcription, Genetic - physiology</subject><subject>transfection</subject><issn>0962-1075</issn><issn>1365-2583</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9vEzEQxS0EomnhK8CKA7ddxvb6n8SlrWip1JZDizhajnc2cdhkg70rkm-Pw0ZF4gKWLD_ZvzfyvCGkoFDRvD6sKsqlKJnQvGIAospbyGr3jMyeHp6TGRjJSgpKnJDTlFYAoI00L8kJFYZJbcSM6BZjDEPYFF1YLIfSL13Wy37dd_1ixGIbsxwwFvn2HBtMhcPFfjuEV-RF67qEr4_nGXm8-vR4-bm8_XJ9c3l-W_paS1l66SmKhgqNtVJz7dE7BXPpJNONp6aRLaWNNEICOg2gnADGmePgWHbwM_J-Kps_8mPENNh1SB67zm2wH5OVSmtFKfsnSFWtTW45g-_-Alf9GDe5B8ugVkwxIzOkJ8jHPqWIrd3GsHZxbynYwwjsyh6Stoek7WEE9vcI7C5b3xzrj_M1Nn-Mx8wz8HECfoYO9_9d2N7cXWSR7eVkD2nA3ZPdxe85DK6E_XZ_be9BaXXxcGfrzL-d-Nb11i1iSPbrAwPKgQIwLTn_BQriqsA</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Pham, D.Q.D</creator><creator>Chavez, C.A</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>ferritin light-chain homologue promoter in Aedes aegypti</title><author>Pham, D.Q.D ; Chavez, C.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4866-c6c1e5d158e477b8ceca70b6a628dc19d6f11d69560ea8007a50232a30a2e473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aedes - genetics</topic><topic>Aedes aegypti</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cells, Cultured</topic><topic>chromosome mapping</topic><topic>Culicidae</topic><topic>DNA footprinting</topic><topic>ferritin</topic><topic>ferritin light-chain homologue promoter</topic><topic>Ferritins - genetics</topic><topic>gene expression regulation</topic><topic>gene regulation</topic><topic>hematophagy</topic><topic>Insect Proteins - genetics</topic><topic>iron</topic><topic>Iron - physiology</topic><topic>Molecular Sequence Data</topic><topic>mosquito</topic><topic>promoter regions</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Promoter Regions, Genetic - physiology</topic><topic>protein subunits</topic><topic>regulatory sequences</topic><topic>Regulatory Sequences, Nucleic Acid</topic><topic>transcription</topic><topic>transcription (genetics)</topic><topic>Transcription, Genetic - physiology</topic><topic>transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pham, D.Q.D</creatorcontrib><creatorcontrib>Chavez, C.A</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Insect molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pham, D.Q.D</au><au>Chavez, C.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ferritin light-chain homologue promoter in Aedes aegypti</atitle><jtitle>Insect molecular biology</jtitle><addtitle>Insect Mol Biol</addtitle><date>2005-06</date><risdate>2005</risdate><volume>14</volume><issue>3</issue><spage>263</spage><epage>270</epage><pages>263-270</pages><issn>0962-1075</issn><eissn>1365-2583</eissn><abstract>Promoters that direct the expression of antipathogenic molecules to primary sites of pathogenic invasions provide a means to interfere with these invasions. Thus, they have the potential to be used in mosquito control. However, exogenous elements are known to lower the fitness of most insects, and given the ability of insects to evolve rapidly, all currently known promoters could be rendered useless. As transgenic mosquitoes may be a major component in the fight against mosquito‐borne diseases, the identification of new mosquito promoters is needed. The promoter of the Aedes aegypti ferritin light‐chain homologue (LCH) gene, a gene whose expression is induced in gut tissues during blood feeding has been identified and mapped. Transfection data indicate that the ferritin LCH promoter is a strong promoter. DNase I footprinting data and Transfac analyses suggest that the ferritin LCH promoter contains putative GATA, E2F, NIT2, TATA and DPE sites. These data together provide the first detailed map of a known ferritin LCH gene.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15926895</pmid><doi>10.1111/j.1365-2583.2005.00556.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Aedes - genetics Aedes aegypti Animals Base Sequence Cells, Cultured chromosome mapping Culicidae DNA footprinting ferritin ferritin light-chain homologue promoter Ferritins - genetics gene expression regulation gene regulation hematophagy Insect Proteins - genetics iron Iron - physiology Molecular Sequence Data mosquito promoter regions Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology protein subunits regulatory sequences Regulatory Sequences, Nucleic Acid transcription transcription (genetics) Transcription, Genetic - physiology transfection |
| title | ferritin light-chain homologue promoter in Aedes aegypti |
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