1α,25-Dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells

Resistance of NOD thymocytes to apoptosis-inducing signals is restored by 1α,25-dihydroxyvitamin D 3 (1α,25(OH) 2D 3), a therapy preventing diabetes in NOD mice. We studied whether modulation of thymocyte apoptosis is due to direct effects on thymic T lymphocytes or indirect effects via thymic dendr...

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Veröffentlicht in:	Journal of autoimmunity 2005-06, Vol.24 (4), p.281-289
Hauptverfasser:	Decallonne, B., van Etten, E., Overbergh, L., Valckx, D., Bouillon, R., Mathieu, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology Apoptosis Apoptosis - drug effects Apoptosis - immunology bcl-X Protein Biological and medical sciences Dendritic Cells - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation - drug effects Gene Expression Regulation - immunology General aspects Immunopathology Injections, Intraperitoneal Interleukin-2 - immunology Medical sciences Mice Mice, Inbred NOD NOD mice Proto-Oncogene Proteins c-bcl-2 - immunology T-Lymphocytes - immunology Thymus Thymus Gland - cytology Thymus Gland - immunology Type 1 diabetes Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives
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