Metalloprotein-dependent decomposition of S-nitrosothiols: Studies on the stabilization and measurement of S-nitrosothiols in tissues

The stabilization of S-nitrosothiols is critical for the development of assays to measure their concentration in tissues. Low-molecular-weight S-nitrosothiols are unstable in tissue homogenates, even in the presence of thiol blockers or metal-ion chelators. The aim of this study was to try and stabi...

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Veröffentlicht in:Free radical biology & medicine 2006-05, Vol.40 (9), p.1654-1663
Hauptverfasser: Mani, Ali R., Ebrahimkhani, Mohammad R., Ippolito, Silvia, Ollosson, Richard, Moore, Kevin P.
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Sprache:eng
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