Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification
To analyze the influence of radiotherapy doses, chemotherapy doses, and clinical parameters on in-field disease control to assess the optimal radiation doses for treatment of non-Hodgkin's lymphoma according to the newly proposed WHO classification. Subjects consisted of 35 extranodal marginal-...
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| Veröffentlicht in: | Strahlentherapie und Onkologie 2005-06, Vol.181 (6), p.385-391 |
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| creator | Sakata, Koh-Ichi Satoh, Masaaki Someya, Masanori Nagakura, Hisayasu Oouchi, Atushi Nakata, Kensei Kogawa, Katsuhisa Koito, Kazumitsu Hareyama, Masato Himi, Tetsuo |
| description | To analyze the influence of radiotherapy doses, chemotherapy doses, and clinical parameters on in-field disease control to assess the optimal radiation doses for treatment of non-Hodgkin's lymphoma according to the newly proposed WHO classification.
Subjects consisted of 35 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type, 75 diffuse large B-cell lymphomas (DLBCL), 14 follicular lymphomas, 17 extranodal natural killer (NK)/T-cell lymphomas, nasal type, eight unclassified peripheral T-cell lymphomas, four anaplastic large-cell lymphomas, T/null cell type, and five others. 59 patients received radiotherapy alone. 98 patients received CHOP, modified CHOP, or more intensive chemotherapy, and six patients were treated with other combination.
No patients with MALT lymphoma had in-field local recurrence. There were no recurrences in DLBCL patients who received chemotherapy in which the doses of adriamycin were > 200 mg/m(2), nor in DLBCL patients who were treated with > 45 Gy. Only nine of 15 patients with T-cell lymphoma treated with < or = 50 Gy and three of five patients treated with > 50 Gy had local control. The dose of adriamycin had no influence on local control of T-cell lymphoma.
T/NK-cell lymphomas were more radioresistant than B-cell lymphomas. The prognosis for peripheral T/NK-cell lymphomas is poor even when treated by irradiation combined with chemotherapy. |
| doi_str_mv | 10.1007/s00066-005-1330-x |
| format | Article |
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Subjects consisted of 35 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type, 75 diffuse large B-cell lymphomas (DLBCL), 14 follicular lymphomas, 17 extranodal natural killer (NK)/T-cell lymphomas, nasal type, eight unclassified peripheral T-cell lymphomas, four anaplastic large-cell lymphomas, T/null cell type, and five others. 59 patients received radiotherapy alone. 98 patients received CHOP, modified CHOP, or more intensive chemotherapy, and six patients were treated with other combination.
No patients with MALT lymphoma had in-field local recurrence. There were no recurrences in DLBCL patients who received chemotherapy in which the doses of adriamycin were > 200 mg/m(2), nor in DLBCL patients who were treated with > 45 Gy. Only nine of 15 patients with T-cell lymphoma treated with < or = 50 Gy and three of five patients treated with > 50 Gy had local control. The dose of adriamycin had no influence on local control of T-cell lymphoma.
T/NK-cell lymphomas were more radioresistant than B-cell lymphomas. The prognosis for peripheral T/NK-cell lymphomas is poor even when treated by irradiation combined with chemotherapy.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-005-1330-x</identifier><identifier>PMID: 15925981</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Antibiotics, Antineoplastic - therapeutic use ; Cancer ; Combined Modality Therapy ; Doxorubicin - therapeutic use ; Female ; Follow-Up Studies ; Humans ; Lymphoma ; Lymphoma, B-Cell - classification ; Lymphoma, B-Cell - drug therapy ; Lymphoma, B-Cell - mortality ; Lymphoma, B-Cell - radiotherapy ; Lymphoma, B-Cell, Marginal Zone - drug therapy ; Lymphoma, B-Cell, Marginal Zone - mortality ; Lymphoma, B-Cell, Marginal Zone - radiotherapy ; Lymphoma, Non-Hodgkin - classification ; Lymphoma, Non-Hodgkin - drug therapy ; Lymphoma, Non-Hodgkin - mortality ; Lymphoma, Non-Hodgkin - radiotherapy ; Male ; Middle Aged ; Radiation therapy ; Retrospective Studies ; Survival Analysis ; Time Factors</subject><ispartof>Strahlentherapie und Onkologie, 2005-06, Vol.181 (6), p.385-391</ispartof><rights>Urban & Vogel München 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-f1b1c9b0e0b10a3bd0840d23de90b2473cab2f63cb9f34dbf667ebf60f429c623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15925981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakata, Koh-Ichi</creatorcontrib><creatorcontrib>Satoh, Masaaki</creatorcontrib><creatorcontrib>Someya, Masanori</creatorcontrib><creatorcontrib>Nagakura, Hisayasu</creatorcontrib><creatorcontrib>Oouchi, Atushi</creatorcontrib><creatorcontrib>Nakata, Kensei</creatorcontrib><creatorcontrib>Kogawa, Katsuhisa</creatorcontrib><creatorcontrib>Koito, Kazumitsu</creatorcontrib><creatorcontrib>Hareyama, Masato</creatorcontrib><creatorcontrib>Himi, Tetsuo</creatorcontrib><title>Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><description>To analyze the influence of radiotherapy doses, chemotherapy doses, and clinical parameters on in-field disease control to assess the optimal radiation doses for treatment of non-Hodgkin's lymphoma according to the newly proposed WHO classification.
Subjects consisted of 35 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type, 75 diffuse large B-cell lymphomas (DLBCL), 14 follicular lymphomas, 17 extranodal natural killer (NK)/T-cell lymphomas, nasal type, eight unclassified peripheral T-cell lymphomas, four anaplastic large-cell lymphomas, T/null cell type, and five others. 59 patients received radiotherapy alone. 98 patients received CHOP, modified CHOP, or more intensive chemotherapy, and six patients were treated with other combination.
No patients with MALT lymphoma had in-field local recurrence. There were no recurrences in DLBCL patients who received chemotherapy in which the doses of adriamycin were > 200 mg/m(2), nor in DLBCL patients who were treated with > 45 Gy. Only nine of 15 patients with T-cell lymphoma treated with < or = 50 Gy and three of five patients treated with > 50 Gy had local control. The dose of adriamycin had no influence on local control of T-cell lymphoma.
T/NK-cell lymphomas were more radioresistant than B-cell lymphomas. The prognosis for peripheral T/NK-cell lymphomas is poor even when treated by irradiation combined with chemotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Cancer</subject><subject>Combined Modality Therapy</subject><subject>Doxorubicin - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell - classification</subject><subject>Lymphoma, B-Cell - drug therapy</subject><subject>Lymphoma, B-Cell - mortality</subject><subject>Lymphoma, B-Cell - radiotherapy</subject><subject>Lymphoma, B-Cell, Marginal Zone - drug therapy</subject><subject>Lymphoma, B-Cell, Marginal Zone - mortality</subject><subject>Lymphoma, B-Cell, Marginal Zone - radiotherapy</subject><subject>Lymphoma, Non-Hodgkin - classification</subject><subject>Lymphoma, Non-Hodgkin - drug therapy</subject><subject>Lymphoma, Non-Hodgkin - mortality</subject><subject>Lymphoma, Non-Hodgkin - radiotherapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1rGzEURUVoiJ2PH5BNEV00KzVPI41mtDShiQuGbBKanZA0UqxUI7mjMbX_fcfYUOjmvc25d3EPQrcUvlGA5r4AgBAEoCaUMSC7MzSnnEkCUr59QnOgjSQNrdsZuizlA4AKLvkFmtFaVrVs6Ry5RdJxX0LB2eOYrY7Y5jQOOeKQ8EaPwaWx4D9hXOOUE1nm7v1XSHcFx32_WedeY21tHrqQ3vGY8bh2-OfyGduoSwk-2Kkhp2t07nUs7ub0r9Dr4_eXhyVZPT_9eFisiGWVGImnhlppwIGhoJnpoOXQVaxzEkzFG2a1qbxg1kjPeGe8EI2bLnheSSsqdoW-Hns3Q_69dWVUfSjWxaiTy9uiRNO2XNZ0Ar_8B37k7TBNUVRb0aYRLT9A9AjZIZcyOK82Q-j1sFcU1EGAOgpQkwB1EKB2U-bzqXhretf9S5wWZ38BaSSCRA</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Sakata, Koh-Ichi</creator><creator>Satoh, Masaaki</creator><creator>Someya, Masanori</creator><creator>Nagakura, Hisayasu</creator><creator>Oouchi, Atushi</creator><creator>Nakata, Kensei</creator><creator>Kogawa, Katsuhisa</creator><creator>Koito, Kazumitsu</creator><creator>Hareyama, Masato</creator><creator>Himi, Tetsuo</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification</title><author>Sakata, Koh-Ichi ; Satoh, Masaaki ; Someya, Masanori ; Nagakura, Hisayasu ; Oouchi, Atushi ; Nakata, Kensei ; Kogawa, Katsuhisa ; Koito, Kazumitsu ; Hareyama, Masato ; Himi, Tetsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-f1b1c9b0e0b10a3bd0840d23de90b2473cab2f63cb9f34dbf667ebf60f429c623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibiotics, Antineoplastic - 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Academic</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakata, Koh-Ichi</au><au>Satoh, Masaaki</au><au>Someya, Masanori</au><au>Nagakura, Hisayasu</au><au>Oouchi, Atushi</au><au>Nakata, Kensei</au><au>Kogawa, Katsuhisa</au><au>Koito, Kazumitsu</au><au>Hareyama, Masato</au><au>Himi, Tetsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><addtitle>Strahlenther Onkol</addtitle><date>2005-06</date><risdate>2005</risdate><volume>181</volume><issue>6</issue><spage>385</spage><epage>391</epage><pages>385-391</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract>To analyze the influence of radiotherapy doses, chemotherapy doses, and clinical parameters on in-field disease control to assess the optimal radiation doses for treatment of non-Hodgkin's lymphoma according to the newly proposed WHO classification.
Subjects consisted of 35 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type, 75 diffuse large B-cell lymphomas (DLBCL), 14 follicular lymphomas, 17 extranodal natural killer (NK)/T-cell lymphomas, nasal type, eight unclassified peripheral T-cell lymphomas, four anaplastic large-cell lymphomas, T/null cell type, and five others. 59 patients received radiotherapy alone. 98 patients received CHOP, modified CHOP, or more intensive chemotherapy, and six patients were treated with other combination.
No patients with MALT lymphoma had in-field local recurrence. There were no recurrences in DLBCL patients who received chemotherapy in which the doses of adriamycin were > 200 mg/m(2), nor in DLBCL patients who were treated with > 45 Gy. Only nine of 15 patients with T-cell lymphoma treated with < or = 50 Gy and three of five patients treated with > 50 Gy had local control. The dose of adriamycin had no influence on local control of T-cell lymphoma.
T/NK-cell lymphomas were more radioresistant than B-cell lymphomas. The prognosis for peripheral T/NK-cell lymphomas is poor even when treated by irradiation combined with chemotherapy.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15925981</pmid><doi>10.1007/s00066-005-1330-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Antibiotics, Antineoplastic - therapeutic use Cancer Combined Modality Therapy Doxorubicin - therapeutic use Female Follow-Up Studies Humans Lymphoma Lymphoma, B-Cell - classification Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - mortality Lymphoma, B-Cell - radiotherapy Lymphoma, B-Cell, Marginal Zone - drug therapy Lymphoma, B-Cell, Marginal Zone - mortality Lymphoma, B-Cell, Marginal Zone - radiotherapy Lymphoma, Non-Hodgkin - classification Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - mortality Lymphoma, Non-Hodgkin - radiotherapy Male Middle Aged Radiation therapy Retrospective Studies Survival Analysis Time Factors |
| title | Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification |
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