Acute changes of biventricular gene expression in volume and right ventricular pressure overload

We investigated the effects of acute volume and RV pressure overload on biventricular function and gene expression of BNP, pro-inflammatory cytokines (IL-6 and TNF-α), iNOS, growth factors (IGF-1, ppET-1), ACE and Ca 2+-handling proteins (SERCA2a, phospholamban and calsequestrin). Male Wistar rats (...

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Veröffentlicht in:	Life sciences (1973) 2006-04, Vol.78 (22), p.2633-2642
Hauptverfasser:	Roncon-Albuquerque, Roberto, Vasconcelos, Mariana, Lourenço, André P., Brandão-Nogueira, Ana, Teles, Antónia, Henriques-Coelho, Tiago, Leite-Moreira, Adelino F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Biological Factors - genetics Biological Factors - metabolism Dextrans - administration & dosage Disease Models, Animal Gene expression Gene Expression - physiology Growth factors Heart Ventricles - metabolism Hemodynamics Hemodynamics - genetics Ligation - methods Male Mechanotransduction Mechanotransduction, Cellular - genetics Myocytes, Cardiac - physiology Pulmonary Artery - surgery Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Ventricular Dysfunction, Right - genetics Ventricular Dysfunction, Right - metabolism Ventricular Remodeling - physiology
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