Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum

Bioassay-guided fractionation of the CH 2Cl 2-soluble fraction led to the isolation of three PTP1B inhibitory diterpenoids, acanthoic acid (2), ent-kaur-16-en-19-oic acid (5), and 16αH,17-isovaleryloxy- ent-kauran-19-oic acid (7), along with their five derivatives. Inhibition of protein tyrosine pho...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-06, Vol.16 (11), p.3061-3064
Hauptverfasser:	Na, MinKyun, Oh, Won Keun, Kim, Young Ho, Cai, Xing Fu, Kim, SoHee, Kim, Bo Yeon, Ahn, Jong Seog
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthopanax koreanum Araliaceae Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenoids Eleutherococcus - chemistry General pharmacology Medical sciences Molecular Structure Non-competitive inhibitor Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Protein tyrosine phosphatase 1B (PTP1B) Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism
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