Rapid determination of trace amounts of minoxidil in hamster skin follicles with various formulations using narrow-bore LC/EC

A sensitive liquid chromatographic method with electrochemistry (LC/EC) was developed for the determination of trace of minoxidil in hamster skin follicles after topical administration of the ear using various formulations. The minoxidil in the sebaceous glands of the hamster ear was isolated from t...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2005-07, Vol.38 (3), p.532-536
Hauptverfasser:	Huang, Tiehua, Garceau, Michelle E., Ramstad, Tore, Stehle, Randall G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Cricetinae Dermis - metabolism Dosage Forms Ear Electrochemical detection Electrochemistry - methods Follicles Formulation Fundamental and applied biological sciences. Psychology General pharmacology Hydrogen-Ion Concentration Medical sciences Microbore liquid chromatography Minoxidil Minoxidil - analysis Minoxidil - isolation & purification Minoxidil - pharmacokinetics Pharmacology. Drug treatments Polyethylene Glycols - chemistry Reproducibility of Results Sebaceous Glands - metabolism Solubility Solvents - chemistry Trichloroacetic Acid - chemistry
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