Tumor lysate and IL-18 loaded dendritic cells elicits Th1 response, tumor-specific CD8+ cytotoxic T cells in patients with malignant glioma

In this study, we demonstrate that tumor lysate-loaded dendritic cells can elicit a specific CD8+ cytotoxic T lymphocyte response against autologous tumor cells in patients with malignant glioma. CTL from three of five patients expressed strong cytolytic activity against autologous glioma cells, did...

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Veröffentlicht in:	Journal of neuro-oncology 2005-04, Vol.72 (2), p.107-113
Hauptverfasser:	YAMANAKA, Ryuya, HONMA, Junpei, TSUCHIYA, Naoto, YAJIMA, Naoki, KOBAYASHI, Tsutomu, TANAKA, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Brain Neoplasms - immunology CD8-Positive T-Lymphocytes - immunology Culture Media, Conditioned Dendritic Cells - immunology Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Genes, MHC Class I - immunology Glioma - immunology Humans Immunotherapy, Adoptive Interleukin-18 - immunology Lymphocytes, Tumor-Infiltrating - immunology Male Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology T-Lymphocyte Subsets - immunology T-Lymphocytes, Cytotoxic - immunology Th1 Cells - immunology Transduction, Genetic Tumor Cells, Cultured Vertebrates: nervous system and sense organs
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