Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro
The lignans, gomisin G ( 1), schisantherin A ( 2), benzoylgomisin Q ( 3) and isoanwulignan ( 4) were isolated from the stems of Schisandra henryi. Compound 1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound 1 represents a new...
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| Veröffentlicht in: | Fitoterapia 2005-06, Vol.76 (3), p.370-373 |
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| container_title | Fitoterapia |
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| creator | Chen, Ye-Gao Wu, Zheng-Cai Gui, Shi-Hong Lv, Yu-Ping Liao, Xin-Rong Halaweish, Fathi |
| description | The lignans, gomisin G (
1), schisantherin A (
2), benzoylgomisin Q (
3) and isoanwulignan (
4) were isolated from the stems of
Schisandra henryi. Compound
1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound
1 represents a new type of DNA strand scission agent. |
| doi_str_mv | 10.1016/j.fitote.2005.03.012 |
| format | Article |
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1), schisantherin A (
2), benzoylgomisin Q (
3) and isoanwulignan (
4) were isolated from the stems of
Schisandra henryi. Compound
1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound
1 represents a new type of DNA strand scission agent.</description><identifier>ISSN: 0367-326X</identifier><identifier>DOI: 10.1016/j.fitote.2005.03.012</identifier><identifier>PMID: 15893434</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Cell Line, Tumor ; Cytotoxic activity ; DNA - chemistry ; General pharmacology ; Humans ; Lignans ; Lignans - chemistry ; Lignans - pharmacology ; Medical sciences ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Schisandra - chemistry ; Schisandra henryi</subject><ispartof>Fitoterapia, 2005-06, Vol.76 (3), p.370-373</ispartof><rights>2005</rights><rights>2005 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-4a5b87127c2ec5658d8863bcda4ee417d9853760181b5db9cc361026b38f17ac3</citedby><cites>FETCH-LOGICAL-c390t-4a5b87127c2ec5658d8863bcda4ee417d9853760181b5db9cc361026b38f17ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0367326X05000560$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16859298$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15893434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ye-Gao</creatorcontrib><creatorcontrib>Wu, Zheng-Cai</creatorcontrib><creatorcontrib>Gui, Shi-Hong</creatorcontrib><creatorcontrib>Lv, Yu-Ping</creatorcontrib><creatorcontrib>Liao, Xin-Rong</creatorcontrib><creatorcontrib>Halaweish, Fathi</creatorcontrib><title>Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro</title><title>Fitoterapia</title><addtitle>Fitoterapia</addtitle><description>The lignans, gomisin G (
1), schisantherin A (
2), benzoylgomisin Q (
3) and isoanwulignan (
4) were isolated from the stems of
Schisandra henryi. Compound
1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound
1 represents a new type of DNA strand scission agent.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cytotoxic activity</subject><subject>DNA - chemistry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Lignans</subject><subject>Lignans - chemistry</subject><subject>Lignans - pharmacology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Schisandra - chemistry</subject><subject>Schisandra henryi</subject><issn>0367-326X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuP0zAUhbMAMcPAP0DIG9g1-BE7zgZpNDwGqYIFILGznJub6S2JPdhpof8el1aaHau7-c65R19VvRC8FlyYN9t6pCUuWEvOdc1VzYV8VF1yZdqVkubHRfU05y3nQqtGPKkuhLadalRzWaU13QUfMhtTnNlX2FD2YUiebTCFA7HftGzYu8_XDCb0ewp3zMNCe1oOrHAMDuVt_EPAcBwRFhYDm3D3E2fy_4BbnDwDnKbMKLCSS_FZ9Xj0U8bn53tVff_w_tvN7Wr95eOnm-v1ClTHl1XjdW9bIVuQCNpoO1hrVA-DbxAb0Q6d1ao1XFjR66HvAJQRXJpe2VG0HtRV9frUe5_irx3mxc2Uj1N8wLjLzrTWylaaAjYnEFLMOeHo7hPNPh2c4O7o123dya87-nVcueK3xF6e-3f9jMND6Cy3AK_OgM_gpzH5AJQfOGN1JztbuLcnDouNPWFyGQgD4ECpOHVDpP8v-QsvsZ22</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Chen, Ye-Gao</creator><creator>Wu, Zheng-Cai</creator><creator>Gui, Shi-Hong</creator><creator>Lv, Yu-Ping</creator><creator>Liao, Xin-Rong</creator><creator>Halaweish, Fathi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro</title><author>Chen, Ye-Gao ; Wu, Zheng-Cai ; Gui, Shi-Hong ; Lv, Yu-Ping ; Liao, Xin-Rong ; Halaweish, Fathi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-4a5b87127c2ec5658d8863bcda4ee417d9853760181b5db9cc361026b38f17ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cytotoxic activity</topic><topic>DNA - chemistry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Lignans</topic><topic>Lignans - chemistry</topic><topic>Lignans - pharmacology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Schisandra - chemistry</topic><topic>Schisandra henryi</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ye-Gao</creatorcontrib><creatorcontrib>Wu, Zheng-Cai</creatorcontrib><creatorcontrib>Gui, Shi-Hong</creatorcontrib><creatorcontrib>Lv, Yu-Ping</creatorcontrib><creatorcontrib>Liao, Xin-Rong</creatorcontrib><creatorcontrib>Halaweish, Fathi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fitoterapia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ye-Gao</au><au>Wu, Zheng-Cai</au><au>Gui, Shi-Hong</au><au>Lv, Yu-Ping</au><au>Liao, Xin-Rong</au><au>Halaweish, Fathi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro</atitle><jtitle>Fitoterapia</jtitle><addtitle>Fitoterapia</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>76</volume><issue>3</issue><spage>370</spage><epage>373</epage><pages>370-373</pages><issn>0367-326X</issn><abstract>The lignans, gomisin G (
1), schisantherin A (
2), benzoylgomisin Q (
3) and isoanwulignan (
4) were isolated from the stems of
Schisandra henryi. Compound
1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound
1 represents a new type of DNA strand scission agent.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15893434</pmid><doi>10.1016/j.fitote.2005.03.012</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Fitoterapia, 2005-06, Vol.76 (3), p.370-373 |
| issn | 0367-326X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cell Line, Tumor Cytotoxic activity DNA - chemistry General pharmacology Humans Lignans Lignans - chemistry Lignans - pharmacology Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Schisandra - chemistry Schisandra henryi |
| title | Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro |
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