FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells

ABSTRACTEndothelial progenitor cells (EPCs) contribute to postnatal neovascularization. Risk factors for coronary artery disease reduce the number of EPCs in humans. Since EPC apoptosis might be a potential mechanism to regulate the number of EPCs, we investigated the effects of oxidative stress and...

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Veröffentlicht in:	The FASEB journal 2005-06, Vol.19 (8), p.974-976
Hauptverfasser:	Urbich, Carmen, Knau, Andrea, Fichtlscherer, Stephan, Walter, Dirk H, Brůhl, Thomas, Potente, Michael, Hofmann, Wolf K, de Vos, Sven, Zeiher, Andreas M, Dimmeler, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - physiology Atorvastatin Calcium Bcl-2-Like Protein 11 cell death Cell Line Cell Survival - drug effects Cells, Cultured Endothelial Cells - physiology Flow Cytometry forkhead transcription factors Gene Expression - drug effects Heptanoic Acids - pharmacology Humans Hydrogen Peroxide - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Leukocytes, Mononuclear Membrane Proteins - genetics Membrane Proteins - physiology Oxidative Stress Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PI3K/Akt signaling Promoter Regions, Genetic - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Pyrroles - pharmacology statins Stem Cells - physiology Transcription Factors - physiology Transfection Umbilical Veins
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