Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a beta-actin hybrid promoter

Gene therapy for acute cardiac events such as myocardial infarction requires early gene expression over an entire region of myocardium, which has not been possible using adeno-associated virus (AAV) vectors to date. Here we demonstrate marked improvement in the distribution and rapidity of gene expr...

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Veröffentlicht in:	Molecular therapy 2005-06, Vol.11 (6), p.980-985
Hauptverfasser:	Kawamoto, Shunsuke, Shi, Qun, Nitta, Yoshio, Miyazaki, Jun-ichi, Allen, Margaret D
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Alkaline Phosphatase - analysis Alkaline Phosphatase - genetics Animals Dependovirus - genetics Gene Expression Genes, Reporter - genetics Genetic Vectors - genetics Male Myocardium - chemistry Myocardium - metabolism Promoter Regions, Genetic - genetics Rats Transduction, Genetic
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