Macrophage's Proinflammatory Response to a Mycobacterial Infection Is Dependent on Sphingosine Kinase-Mediated Activation of Phosphatidylinositol Phospholipase C, Protein Kinase C, ERK1/2, and Phosphatidylinositol 3-Kinase

Previous studies have shown that the ability of Mycobacterium tuberculosis to block a Ca(2+) flux is an important step in its capacity to halt phagosome maturation. This affect on Ca(2+) release results from M. tuberculosis inhibition of sphingosine kinase (SPK) activity. However, these studies did...

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Veröffentlicht in:	Journal of Immunology 2006-05, Vol.176 (9), p.5494-5503
Hauptverfasser:	Yadav, Mahesh, Clark, Lindsay, Schorey, Jeffrey S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - enzymology Bone Marrow - microbiology Calcium - metabolism Cells, Cultured Chemokine CCL5 - biosynthesis Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Granulocyte Colony-Stimulating Factor - biosynthesis Inflammation Mediators - metabolism Interleukin-6 - biosynthesis Macrophages - metabolism Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mycobacterium avium Mycobacterium avium - physiology Mycobacterium Infections - enzymology Mycobacterium Infections - microbiology Mycobacterium smegmatis Mycobacterium smegmatis - physiology Mycobacterium tuberculosis Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Diacylglycerol-Lyase - metabolism Phosphoinositide Phospholipase C Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Kinase C - metabolism Signal Transduction Tumor Necrosis Factor-alpha - biosynthesis
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