Determination of Antifungal Activities in Serum Samples from Mice Treated with Different Antifungal Drugs Allows Detection of an Active Metabolite of Itraconazole

To establish an in vitro method of predicting in vivo efficacy of antifungal drugs against Candida albicans and Aspergillus fumigatus, the antifungal activities of fluconazole, itraconazole, and amphotericin B were determined in mouse serum. The minimum inhibitory concentration (MIC) of each drug wa...

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Veröffentlicht in:	Microbiology and immunology 2006, Vol.50 (4), p.281-292
Hauptverfasser:	Maki, Katsuyuki, Watabe, Etsuko, Iguchi, Yumi, Nakamura, Hideko, Tomishima, Masaki, Ohki, Hidenori, Yamada, Akira, Matsumoto, Satoru, Ikeda, Fumiaki, Tawara, Shuichi, Mutoh, Seitaro
Format:	Artikel
Sprache:	eng
Schlagworte:	active metabolite amphotericin B Animals Antifungal Agents - blood Antifungal Agents - pharmacokinetics Antifungal Agents - pharmacology antifungal titer Aspergillus fumigatus Aspergillus fumigatus - drug effects bioautography Biotransformation Candida albicans Candida albicans - drug effects ex vivo itraconazole Itraconazole - blood Itraconazole - pharmacokinetics Itraconazole - pharmacology Male Mice Mice, Inbred ICR Microbial Sensitivity Tests
Online-Zugang:	Volltext
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