Current status of gene therapy strategies to treat HIV/AIDS
Progress in developing effective gene transfer approaches to treat HIV-1 infection has been steady. Many different transgenes have been reported to inhibit HIV-1 in vitro. However, effective translation of such results to clinical practice, or even to animal models of AIDS, has been challenging. Amo...
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| Veröffentlicht in: | Molecular therapy 2005-06, Vol.11 (6), p.823-842 |
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| container_title | Molecular therapy |
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| creator | Strayer, David S Akkina, Ramesh Bunnell, Bruce A Dropulic, Boro Planelles, Vicente Pomerantz, Roger J Rossi, John J Zaia, John A |
| description | Progress in developing effective gene transfer approaches to treat HIV-1 infection has been steady. Many different transgenes have been reported to inhibit HIV-1 in vitro. However, effective translation of such results to clinical practice, or even to animal models of AIDS, has been challenging. Among the reasons for this failure are uncertainty as to the most effective cell population(s) to target, the diffuseness of these target cells in the body, and ineffective or insufficiently durable gene delivery. Better understanding of the HIV-1 replicative cycle, host factors involved in HIV-1 infection, vector biology and application, transgene technology, animal models, and clinical study design have all contributed vastly to planning current and future strategies for application of gene therapeutic approaches to the treatment of AIDS. This review focuses on the newest developments in these areas and provides a strong basis for renewed optimism that gene therapy will have an important role to play in treating people infected with HIV-1. |
| doi_str_mv | 10.1016/j.ymthe.2005.01.020 |
| format | Article |
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Many different transgenes have been reported to inhibit HIV-1 in vitro. However, effective translation of such results to clinical practice, or even to animal models of AIDS, has been challenging. Among the reasons for this failure are uncertainty as to the most effective cell population(s) to target, the diffuseness of these target cells in the body, and ineffective or insufficiently durable gene delivery. Better understanding of the HIV-1 replicative cycle, host factors involved in HIV-1 infection, vector biology and application, transgene technology, animal models, and clinical study design have all contributed vastly to planning current and future strategies for application of gene therapeutic approaches to the treatment of AIDS. This review focuses on the newest developments in these areas and provides a strong basis for renewed optimism that gene therapy will have an important role to play in treating people infected with HIV-1.</description><identifier>ISSN: 1525-0016</identifier><identifier>EISSN: 1525-0024</identifier><identifier>DOI: 10.1016/j.ymthe.2005.01.020</identifier><identifier>PMID: 15922953</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - therapy ; AIDS ; Animals ; Gene therapy ; Genetic Therapy - methods ; Genetic Vectors - genetics ; HIV ; HIV Infections - therapy ; HIV-1 - genetics ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Mice ; Models, Animal ; Pathology ; Transgenes ; Vectors (Biology)</subject><ispartof>Molecular therapy, 2005-06, Vol.11 (6), p.823-842</ispartof><rights>Copyright Nature Publishing Group Jun 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-8894ac96e932227a498670a4d4e68ebc52fe5051d986d69a3670c2f0ab8969f03</citedby><cites>FETCH-LOGICAL-c400t-8894ac96e932227a498670a4d4e68ebc52fe5051d986d69a3670c2f0ab8969f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1792783918?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15922953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strayer, David S</creatorcontrib><creatorcontrib>Akkina, Ramesh</creatorcontrib><creatorcontrib>Bunnell, Bruce A</creatorcontrib><creatorcontrib>Dropulic, Boro</creatorcontrib><creatorcontrib>Planelles, Vicente</creatorcontrib><creatorcontrib>Pomerantz, Roger J</creatorcontrib><creatorcontrib>Rossi, John J</creatorcontrib><creatorcontrib>Zaia, John A</creatorcontrib><title>Current status of gene therapy strategies to treat HIV/AIDS</title><title>Molecular therapy</title><addtitle>Mol Ther</addtitle><description>Progress in developing effective gene transfer approaches to treat HIV-1 infection has been steady. Many different transgenes have been reported to inhibit HIV-1 in vitro. However, effective translation of such results to clinical practice, or even to animal models of AIDS, has been challenging. Among the reasons for this failure are uncertainty as to the most effective cell population(s) to target, the diffuseness of these target cells in the body, and ineffective or insufficiently durable gene delivery. Better understanding of the HIV-1 replicative cycle, host factors involved in HIV-1 infection, vector biology and application, transgene technology, animal models, and clinical study design have all contributed vastly to planning current and future strategies for application of gene therapeutic approaches to the treatment of AIDS. This review focuses on the newest developments in these areas and provides a strong basis for renewed optimism that gene therapy will have an important role to play in treating people infected with HIV-1.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - therapy</subject><subject>AIDS</subject><subject>Animals</subject><subject>Gene therapy</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors - genetics</subject><subject>HIV</subject><subject>HIV Infections - therapy</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Mice</subject><subject>Models, Animal</subject><subject>Pathology</subject><subject>Transgenes</subject><subject>Vectors (Biology)</subject><issn>1525-0016</issn><issn>1525-0024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE1LAzEQhoMotlZ_gaALgrfdTrKbbIKnUj9aKHjw4xrS3dna0t2tSfbQf29qSwVPM8w88zI8hFxTSChQMVwl29p_YcIAeAI0AQYnpE854zEAy06PPRU9cuHcKnSUK3FOeqEwpnjaJw_jzlpsfOS88Z2L2ipaYINRCLZmsw1jazwulugi30beovHRZPo5HE0f3y7JWWXWDq8OdUA-np_ex5N49voyHY9mcZEB-FhKlZlCCVQpYyw3mZIiB5OVGQqJ84KzCjlwWoZ5KZRJw7ZgFZi5VEJVkA7I_T53Y9vvDp3X9dIVuF6bBtvOaZHLXHHKAnj3D1y1nW3Cb5rmiuUyVVQGKt1ThW2ds1jpjV3Wxm41Bb0zq1f616zemdVAdTAbrm4O2d28xvLv5qAyALd7oAkiLR6B2u9iKLD0BzMFfcg</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Strayer, David S</creator><creator>Akkina, Ramesh</creator><creator>Bunnell, Bruce A</creator><creator>Dropulic, Boro</creator><creator>Planelles, Vicente</creator><creator>Pomerantz, Roger J</creator><creator>Rossi, John J</creator><creator>Zaia, John A</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Current status of gene therapy strategies to treat HIV/AIDS</title><author>Strayer, David S ; 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| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - therapy AIDS Animals Gene therapy Genetic Therapy - methods Genetic Vectors - genetics HIV HIV Infections - therapy HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Humans Mice Models, Animal Pathology Transgenes Vectors (Biology) |
| title | Current status of gene therapy strategies to treat HIV/AIDS |
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