Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation
ABSTRACT Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mol...
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| Veröffentlicht in: | American journal of perinatology 2006-04, Vol.23 (3), p.163-166 |
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| container_title | American journal of perinatology |
| container_volume | 23 |
| creator | Sherer, David M Dalloul, Mudar Stimphil, Raphael Hellmann, Mira Khoury-Collado, Fady Osho, Joseph Fomitcheva, Larissa Brennan, Kelly J Abulafia, Ovadia |
| description | ABSTRACT
Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 × 10
9
cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole. |
| doi_str_mv | 10.1055/s-2006-934093 |
| format | Article |
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Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 × 10
9
cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2006-934093</identifier><identifier>PMID: 16586230</identifier><language>eng</language><publisher>United States</publisher><subject>Abortion, Induced ; Adult ; Diagnosis, Differential ; Female ; HELLP Syndrome - blood ; HELLP Syndrome - diagnosis ; HELLP Syndrome - pathology ; Humans ; Hydatidiform Mole - diagnosis ; Hydatidiform Mole - diagnostic imaging ; Hydatidiform Mole - genetics ; Hydatidiform Mole - pathology ; Pregnancy ; Pregnancy Trimester, Second ; Ultrasonography, Prenatal ; Uterine Neoplasms - diagnosis ; Uterine Neoplasms - diagnostic imaging ; Uterine Neoplasms - genetics ; Uterine Neoplasms - pathology</subject><ispartof>American journal of perinatology, 2006-04, Vol.23 (3), p.163-166</ispartof><rights>Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-56af336414f95bfb4f5fb96f3228684915b2e7586710d64c1e0b55809799575c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-934093.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2006-934093$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16586230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sherer, David M</creatorcontrib><creatorcontrib>Dalloul, Mudar</creatorcontrib><creatorcontrib>Stimphil, Raphael</creatorcontrib><creatorcontrib>Hellmann, Mira</creatorcontrib><creatorcontrib>Khoury-Collado, Fady</creatorcontrib><creatorcontrib>Osho, Joseph</creatorcontrib><creatorcontrib>Fomitcheva, Larissa</creatorcontrib><creatorcontrib>Brennan, Kelly J</creatorcontrib><creatorcontrib>Abulafia, Ovadia</creatorcontrib><title>Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 × 10
9
cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole.</description><subject>Abortion, Induced</subject><subject>Adult</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>HELLP Syndrome - blood</subject><subject>HELLP Syndrome - diagnosis</subject><subject>HELLP Syndrome - pathology</subject><subject>Humans</subject><subject>Hydatidiform Mole - diagnosis</subject><subject>Hydatidiform Mole - diagnostic imaging</subject><subject>Hydatidiform Mole - genetics</subject><subject>Hydatidiform Mole - pathology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Ultrasonography, Prenatal</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - diagnostic imaging</subject><subject>Uterine Neoplasms - genetics</subject><subject>Uterine Neoplasms - pathology</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1O3DAUha2qVZnSLrutvOqKUDuOf7JEoylTaRBIgLq0nORamCY2tR1Q-ix92BpmpK5YWT7n87HuPQh9puSUEs6_paomRFQta0jL3qAVJa2qlFT8LVoRyXhFBaNH6ENK94TQWhH1Hh1RwZWoGVmhv2f9nAFf-gQZB4uv4REi4C1MYVySSyd4M8KjyTDgnSsW3vg_ywRFN75I4QlfjcUdy-t1mH3G14sfYpgAO48NvjLZQVGfXL57ucbszIi3y1CMwdkQJ3wRRsAmYyrxT4BfCZ9DysUO_iN6Z82Y4NPhPEa33zc36221uzz_sT7bVT2rVa64MJYx0dDGtryzXWO57VphWV0roZqW8q4GWSaWlAyi6SmQjnNFWtm2XPKeHaOv-9yHGH7P5Xc9udTDOBoPYU5ayLJQ2bACVnuwjyGlCFY_RDeZuGhK9HMdOunnOvS-jsJ_OQTP3QTDf_qw_wKc7IF852ACfR_m6Muor-T9AxodksI</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Sherer, David M</creator><creator>Dalloul, Mudar</creator><creator>Stimphil, Raphael</creator><creator>Hellmann, Mira</creator><creator>Khoury-Collado, Fady</creator><creator>Osho, Joseph</creator><creator>Fomitcheva, Larissa</creator><creator>Brennan, Kelly J</creator><creator>Abulafia, Ovadia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation</title><author>Sherer, David M ; Dalloul, Mudar ; Stimphil, Raphael ; Hellmann, Mira ; Khoury-Collado, Fady ; Osho, Joseph ; Fomitcheva, Larissa ; Brennan, Kelly J ; Abulafia, Ovadia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-56af336414f95bfb4f5fb96f3228684915b2e7586710d64c1e0b55809799575c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Abortion, Induced</topic><topic>Adult</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>HELLP Syndrome - blood</topic><topic>HELLP Syndrome - diagnosis</topic><topic>HELLP Syndrome - pathology</topic><topic>Humans</topic><topic>Hydatidiform Mole - diagnosis</topic><topic>Hydatidiform Mole - diagnostic imaging</topic><topic>Hydatidiform Mole - genetics</topic><topic>Hydatidiform Mole - pathology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Ultrasonography, Prenatal</topic><topic>Uterine Neoplasms - diagnosis</topic><topic>Uterine Neoplasms - diagnostic imaging</topic><topic>Uterine Neoplasms - genetics</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sherer, David M</creatorcontrib><creatorcontrib>Dalloul, Mudar</creatorcontrib><creatorcontrib>Stimphil, Raphael</creatorcontrib><creatorcontrib>Hellmann, Mira</creatorcontrib><creatorcontrib>Khoury-Collado, Fady</creatorcontrib><creatorcontrib>Osho, Joseph</creatorcontrib><creatorcontrib>Fomitcheva, Larissa</creatorcontrib><creatorcontrib>Brennan, Kelly J</creatorcontrib><creatorcontrib>Abulafia, Ovadia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sherer, David M</au><au>Dalloul, Mudar</au><au>Stimphil, Raphael</au><au>Hellmann, Mira</au><au>Khoury-Collado, Fady</au><au>Osho, Joseph</au><au>Fomitcheva, Larissa</au><au>Brennan, Kelly J</au><au>Abulafia, Ovadia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>23</volume><issue>3</issue><spage>163</spage><epage>166</epage><pages>163-166</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><abstract>ABSTRACT
Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 × 10
9
cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole.</abstract><cop>United States</cop><pmid>16586230</pmid><doi>10.1055/s-2006-934093</doi><tpages>4</tpages></addata></record> |
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| subjects | Abortion, Induced Adult Diagnosis, Differential Female HELLP Syndrome - blood HELLP Syndrome - diagnosis HELLP Syndrome - pathology Humans Hydatidiform Mole - diagnosis Hydatidiform Mole - diagnostic imaging Hydatidiform Mole - genetics Hydatidiform Mole - pathology Pregnancy Pregnancy Trimester, Second Ultrasonography, Prenatal Uterine Neoplasms - diagnosis Uterine Neoplasms - diagnostic imaging Uterine Neoplasms - genetics Uterine Neoplasms - pathology |
| title | Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation |
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