The Striatal and Extrastriatal D2 D3 Receptor-Binding Profile of Clozapine in Patients with Schizophrenia

Positron emission tomography (PET) studies reveal that clozapine at clinically used doses occupies less than 60% of D2/D3 dopamine receptors in human striatum. Here, the occupancy of D2/D3 dopamine receptors by clozapine in patients with schizophrenia was determined to test the hypothesis that cloza...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2006-05, Vol.31 (5), p.1027-1035
Hauptverfasser:	GRÜNDER, Gerhard, LANDVOGT, Christian, RÖSCH, Frank, WONG, Dean F, BARTENSTEIN, Peter, VERNALEKEN, Ingo, BUCHHOLZ, Hans-Georg, ONDRACEK, Jasmin, SIESSMEIER, Thomas, HÄRTTER, Sebastian, SCHRECKENBERGER, Mathias, STOETER, Peter, HIEMKE, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Antipsychotic Agents - blood Antipsychotic Agents - pharmacology Antipsychotics Benzamides Binding, Competitive - drug effects Binding, Competitive - physiology Biological and medical sciences Clozapine - blood Clozapine - pharmacology Corpus Striatum - diagnostic imaging Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Dopamine - metabolism Dose-Response Relationship, Drug Drug dosages Female Humans Male Medical sciences Middle Aged Neuropharmacology Patients Pharmacology. Drug treatments Plasma Positron-Emission Tomography Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Psychotropic drugs Pyrrolidines Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - drug effects Receptors, Dopamine D3 - metabolism Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Schizophrenia - metabolism Temporal Lobe - drug effects Temporal Lobe - metabolism Tomography
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