Synthesis of a novel class of fatty acids-derived isoquinolines

Two series of novel tetrahydroisoquinoline derivatives bearing at C-1 position a carbon chain derived from fatty acids were prepared employing two complementary synthetic methodologies. The Pictet–Spengler condensation was performed on myristyl, palmityl, stearyl and oleyl aldehydes, whereas the Bis...

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Veröffentlicht in:	Chemistry and physics of lipids 2005-06, Vol.135 (2), p.131-145
Hauptverfasser:	Matuszewska, Iwona, Leniewski, Andrzej, Roszkowski, Piotr, Czarnocki, Zbigniew
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood-Brain Barrier - metabolism Fatty acids Fatty Acids - chemistry Lipids Magnetic Resonance Spectroscopy N-Acyldopamines Neurotransmitters Parkinson disease Tetrahydroisoquinolines - chemical synthesis Tetrahydroisoquinolines - chemistry Tetrahydroisoquinolines - pharmacokinetics
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