Interaction of brain noradrenergic system and the hypothalamic–pituitary–adrenal (HPA) axis in man
Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationsh...
Gespeichert in:
| Veröffentlicht in: | Psychoneuroendocrinology 2005-09, Vol.30 (8), p.807-814 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 814 |
|---|---|
| container_issue | 8 |
| container_start_page | 807 |
| container_title | Psychoneuroendocrinology |
| container_volume | 30 |
| creator | Young, Elizabeth A. Abelson, James L. Cameron, Oliver G. |
| description | Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship.
Untreated subjects with pure MDD (
n=13), MDD with comorbid anxiety disorders (
n=17), and pure anxiety disorders (
n=15) were recruited by advertising. Age and sex matched control subjects were recruited for each subject with a psychiatric diagnosis (
n=45). All subjects underwent a social stressor, the Trier Social Stress Test (TSST), and blood was collected for ACTH assay. These same subjects also underwent a clonidine challenge study for assessment of growth hormone release as a marker of tonic noradrenergic activation.
Examining log transformed area under the curve response for each hormone, a significant negative relationship (simple regression) was observed between systems in normal subjects. This relationship was preserved in anxiety subjects. However, both pure depressed and comorbid depressed and anxiety subjects demonstrated disruption of this relationship.
Under normal circumstances, noradrenergic systems can influence the magnitude of the HPA axis response to stress. However, in subjects with major depression, HPA axis activation appears autonomous of noradrenergic influence. |
| doi_str_mv | 10.1016/j.psyneuen.2005.03.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67875623</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0306453005000685</els_id><sourcerecordid>67875623</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-f2795b0306d3a7b563a3da5fab26594ec5ed9737525dc00ee0e9bb894892f1823</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhi0EosvCK1S-gOCQ4MSxE9-oKqCVKsEBztbEnrBeJU6wnYq98Q68IU-Cl13UI6fx4ftnxt8QclmxsmKVfLsvl3jwuKIva8ZEyXjJmHpENlXX8oJzyR6TDeNMFo3g7II8i3HPGJOdrJ-Si0p0SqpKbchw6xMGMMnNns4D7QM4T_0cwAb0GL45Q-MhJpwoeEvTDunusMxpByNMzvz--WtxaXUJwiG__4ZgpK9vPl-9ofDDRZq7TeCfkycDjBFfnOuWfP3w_sv1TXH36ePt9dVdYZqmScVQt0r0x7Uth7YXkgO3IAboaylUg0agVS1vRS2sYQyRoer7TjWdqoeqq_mWvDr1XcL8fcWY9OSiwXEEj_MatWy7VsiaZ1CeQBPmGAMOegluyr_QFdNHw3qv_xnWR8OacZ0N5-DlecLaT2gfYmelGXh5BiAaGIcA3rj4wOUTNHU-0pa8O3GYfdw7DDoah96gdQFN0nZ2_9vlD8-9oGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67875623</pqid></control><display><type>article</type><title>Interaction of brain noradrenergic system and the hypothalamic–pituitary–adrenal (HPA) axis in man</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Young, Elizabeth A. ; Abelson, James L. ; Cameron, Oliver G.</creator><creatorcontrib>Young, Elizabeth A. ; Abelson, James L. ; Cameron, Oliver G.</creatorcontrib><description>Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship.
Untreated subjects with pure MDD (
n=13), MDD with comorbid anxiety disorders (
n=17), and pure anxiety disorders (
n=15) were recruited by advertising. Age and sex matched control subjects were recruited for each subject with a psychiatric diagnosis (
n=45). All subjects underwent a social stressor, the Trier Social Stress Test (TSST), and blood was collected for ACTH assay. These same subjects also underwent a clonidine challenge study for assessment of growth hormone release as a marker of tonic noradrenergic activation.
Examining log transformed area under the curve response for each hormone, a significant negative relationship (simple regression) was observed between systems in normal subjects. This relationship was preserved in anxiety subjects. However, both pure depressed and comorbid depressed and anxiety subjects demonstrated disruption of this relationship.
Under normal circumstances, noradrenergic systems can influence the magnitude of the HPA axis response to stress. However, in subjects with major depression, HPA axis activation appears autonomous of noradrenergic influence.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/j.psyneuen.2005.03.009</identifier><identifier>PMID: 15896919</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>ACTH ; Adrenocorticotropic Hormone - blood ; Adult ; Anxiety disorders ; Anxiety Disorders - blood ; Anxiety Disorders - complications ; Anxiety Disorders - physiopathology ; Area Under Curve ; Behavioral psychophysiology ; Biological and medical sciences ; Clonidine ; Cortisol ; Depression ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - physiopathology ; Female ; Fundamental and applied biological sciences. Psychology ; Growth hormone ; Growth Hormone - blood ; Hormones and behavior ; Humans ; Hypothalamo-Hypophyseal System - metabolism ; Hypothalamo-Hypophyseal System - physiopathology ; Linear Models ; Locus Coeruleus - metabolism ; Locus Coeruleus - physiopathology ; Male ; Matched-Pair Analysis ; Neural Pathways - metabolism ; Neural Pathways - physiopathology ; Neurotransmission and behavior ; Noradrenergic system ; Norepinephrine - metabolism ; Pituitary-Adrenal System - metabolism ; Pituitary-Adrenal System - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Reference Values ; Social anxiety disorder ; Stress ; Stress, Psychological - blood ; Stress, Psychological - physiopathology</subject><ispartof>Psychoneuroendocrinology, 2005-09, Vol.30 (8), p.807-814</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-f2795b0306d3a7b563a3da5fab26594ec5ed9737525dc00ee0e9bb894892f1823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306453005000685$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16864287$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15896919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, Elizabeth A.</creatorcontrib><creatorcontrib>Abelson, James L.</creatorcontrib><creatorcontrib>Cameron, Oliver G.</creatorcontrib><title>Interaction of brain noradrenergic system and the hypothalamic–pituitary–adrenal (HPA) axis in man</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship.
Untreated subjects with pure MDD (
n=13), MDD with comorbid anxiety disorders (
n=17), and pure anxiety disorders (
n=15) were recruited by advertising. Age and sex matched control subjects were recruited for each subject with a psychiatric diagnosis (
n=45). All subjects underwent a social stressor, the Trier Social Stress Test (TSST), and blood was collected for ACTH assay. These same subjects also underwent a clonidine challenge study for assessment of growth hormone release as a marker of tonic noradrenergic activation.
Examining log transformed area under the curve response for each hormone, a significant negative relationship (simple regression) was observed between systems in normal subjects. This relationship was preserved in anxiety subjects. However, both pure depressed and comorbid depressed and anxiety subjects demonstrated disruption of this relationship.
Under normal circumstances, noradrenergic systems can influence the magnitude of the HPA axis response to stress. However, in subjects with major depression, HPA axis activation appears autonomous of noradrenergic influence.</description><subject>ACTH</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adult</subject><subject>Anxiety disorders</subject><subject>Anxiety Disorders - blood</subject><subject>Anxiety Disorders - complications</subject><subject>Anxiety Disorders - physiopathology</subject><subject>Area Under Curve</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Clonidine</subject><subject>Cortisol</subject><subject>Depression</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth hormone</subject><subject>Growth Hormone - blood</subject><subject>Hormones and behavior</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Linear Models</subject><subject>Locus Coeruleus - metabolism</subject><subject>Locus Coeruleus - physiopathology</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Neural Pathways - metabolism</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurotransmission and behavior</subject><subject>Noradrenergic system</subject><subject>Norepinephrine - metabolism</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Pituitary-Adrenal System - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Reference Values</subject><subject>Social anxiety disorder</subject><subject>Stress</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - physiopathology</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EosvCK1S-gOCQ4MSxE9-oKqCVKsEBztbEnrBeJU6wnYq98Q68IU-Cl13UI6fx4ftnxt8QclmxsmKVfLsvl3jwuKIva8ZEyXjJmHpENlXX8oJzyR6TDeNMFo3g7II8i3HPGJOdrJ-Si0p0SqpKbchw6xMGMMnNns4D7QM4T_0cwAb0GL45Q-MhJpwoeEvTDunusMxpByNMzvz--WtxaXUJwiG__4ZgpK9vPl-9ofDDRZq7TeCfkycDjBFfnOuWfP3w_sv1TXH36ePt9dVdYZqmScVQt0r0x7Uth7YXkgO3IAboaylUg0agVS1vRS2sYQyRoer7TjWdqoeqq_mWvDr1XcL8fcWY9OSiwXEEj_MatWy7VsiaZ1CeQBPmGAMOegluyr_QFdNHw3qv_xnWR8OacZ0N5-DlecLaT2gfYmelGXh5BiAaGIcA3rj4wOUTNHU-0pa8O3GYfdw7DDoah96gdQFN0nZ2_9vlD8-9oGg</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Young, Elizabeth A.</creator><creator>Abelson, James L.</creator><creator>Cameron, Oliver G.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Interaction of brain noradrenergic system and the hypothalamic–pituitary–adrenal (HPA) axis in man</title><author>Young, Elizabeth A. ; Abelson, James L. ; Cameron, Oliver G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-f2795b0306d3a7b563a3da5fab26594ec5ed9737525dc00ee0e9bb894892f1823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ACTH</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adult</topic><topic>Anxiety disorders</topic><topic>Anxiety Disorders - blood</topic><topic>Anxiety Disorders - complications</topic><topic>Anxiety Disorders - physiopathology</topic><topic>Area Under Curve</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Clonidine</topic><topic>Cortisol</topic><topic>Depression</topic><topic>Depressive Disorder, Major - blood</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth hormone</topic><topic>Growth Hormone - blood</topic><topic>Hormones and behavior</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Linear Models</topic><topic>Locus Coeruleus - metabolism</topic><topic>Locus Coeruleus - physiopathology</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Neural Pathways - metabolism</topic><topic>Neural Pathways - physiopathology</topic><topic>Neurotransmission and behavior</topic><topic>Noradrenergic system</topic><topic>Norepinephrine - metabolism</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Reference Values</topic><topic>Social anxiety disorder</topic><topic>Stress</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, Elizabeth A.</creatorcontrib><creatorcontrib>Abelson, James L.</creatorcontrib><creatorcontrib>Cameron, Oliver G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, Elizabeth A.</au><au>Abelson, James L.</au><au>Cameron, Oliver G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of brain noradrenergic system and the hypothalamic–pituitary–adrenal (HPA) axis in man</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>30</volume><issue>8</issue><spage>807</spage><epage>814</epage><pages>807-814</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><coden>PSYCDE</coden><abstract>Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and little is known about the influence of psychiatric disorders, which disturb one of these systems, on this relationship.
Untreated subjects with pure MDD (
n=13), MDD with comorbid anxiety disorders (
n=17), and pure anxiety disorders (
n=15) were recruited by advertising. Age and sex matched control subjects were recruited for each subject with a psychiatric diagnosis (
n=45). All subjects underwent a social stressor, the Trier Social Stress Test (TSST), and blood was collected for ACTH assay. These same subjects also underwent a clonidine challenge study for assessment of growth hormone release as a marker of tonic noradrenergic activation.
Examining log transformed area under the curve response for each hormone, a significant negative relationship (simple regression) was observed between systems in normal subjects. This relationship was preserved in anxiety subjects. However, both pure depressed and comorbid depressed and anxiety subjects demonstrated disruption of this relationship.
Under normal circumstances, noradrenergic systems can influence the magnitude of the HPA axis response to stress. However, in subjects with major depression, HPA axis activation appears autonomous of noradrenergic influence.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15896919</pmid><doi>10.1016/j.psyneuen.2005.03.009</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4530 |
| ispartof | Psychoneuroendocrinology, 2005-09, Vol.30 (8), p.807-814 |
| issn | 0306-4530 1873-3360 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67875623 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ACTH Adrenocorticotropic Hormone - blood Adult Anxiety disorders Anxiety Disorders - blood Anxiety Disorders - complications Anxiety Disorders - physiopathology Area Under Curve Behavioral psychophysiology Biological and medical sciences Clonidine Cortisol Depression Depressive Disorder, Major - blood Depressive Disorder, Major - complications Depressive Disorder, Major - physiopathology Female Fundamental and applied biological sciences. Psychology Growth hormone Growth Hormone - blood Hormones and behavior Humans Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiopathology Linear Models Locus Coeruleus - metabolism Locus Coeruleus - physiopathology Male Matched-Pair Analysis Neural Pathways - metabolism Neural Pathways - physiopathology Neurotransmission and behavior Noradrenergic system Norepinephrine - metabolism Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reference Values Social anxiety disorder Stress Stress, Psychological - blood Stress, Psychological - physiopathology |
| title | Interaction of brain noradrenergic system and the hypothalamic–pituitary–adrenal (HPA) axis in man |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T12%3A10%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interaction%20of%20brain%20noradrenergic%20system%20and%20the%20hypothalamic%E2%80%93pituitary%E2%80%93adrenal%20(HPA)%20axis%20in%20man&rft.jtitle=Psychoneuroendocrinology&rft.au=Young,%20Elizabeth%20A.&rft.date=2005-09-01&rft.volume=30&rft.issue=8&rft.spage=807&rft.epage=814&rft.pages=807-814&rft.issn=0306-4530&rft.eissn=1873-3360&rft.coden=PSYCDE&rft_id=info:doi/10.1016/j.psyneuen.2005.03.009&rft_dat=%3Cproquest_cross%3E67875623%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67875623&rft_id=info:pmid/15896919&rft_els_id=S0306453005000685&rfr_iscdi=true |