Autoantigens act as tissue-specific chemoattractants

We have investigated the chemoattractant properties of self‐antigens associated with autoimmune diseases and solid tumors. Many autoantigens induced leukocyte migration, especially by immature dendritic cells (iDC) by interacting with various chemoattractant Gi‐protein‐coupled receptors (GiPCR). Our...

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Veröffentlicht in:	Journal of leukocyte biology 2005-06, Vol.77 (6), p.854-861
Hauptverfasser:	Oppenheim, Joost J., Dong, Hui Fang, Plotz, Paul, Caspi, Rachel R., Dykstra, Michelle, Pierce, Susan, Martin, Roland, Carlos, Casey, Finn, Olivera, Koul, Omanand, Howard, O. M. Zack
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - immunology Autoantigens - immunology Autoimmune Diseases - immunology chemokines Chemotactic Factors - immunology chemotaxis Chemotaxis, Leukocyte - immunology dendritic cells Dendritic Cells - immunology Humans Leukocytes, Mononuclear - immunology Mice migrations Neoplasms - immunology tumor antigens
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