Suppression of Pro-metastasis Phenotypes Expression in Malignant Pleural Mesothelioma by the PI3K Inhibitor LY294002 or the MEK Inhibitor UO126

Background: This study aimed to evaluate the impact of selective abrogation of either the MEK/ERK1/2 (UO126 or PD98059) or the PI3K/AKT (LY294002) signaling cascade on cell proliferation, motility and invasion and production of VEGF (collectively termed pro-metastasis phenotypes) in cultured maligna...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Anticancer research 2006-03, Vol.26 (2A), p.809-821
Hauptverfasser:	COLE, George W, ALLEVA, Annette M, ZUO, Jing T, SEHGAL, Shailen S, YEOW, Wen-Shuz, SCHRUMP, David S, NGUYEN, Dao M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Butadienes - pharmacology Cell Line, Tumor Cell Movement - drug effects Chromones - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Humans Interleukin-8 - biosynthesis MAP Kinase Kinase Kinases - antagonists & inhibitors Medical sciences Mesothelioma - blood supply Mesothelioma - drug therapy Mesothelioma - enzymology Mesothelioma - secondary Morpholines - pharmacology Neoplasm Metastasis Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - pathology Nitriles - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Pleural Neoplasms - blood supply Pleural Neoplasms - drug therapy Pleural Neoplasms - enzymology Pleural Neoplasms - pathology Pneumology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Quinazolines - pharmacology Tumors Tumors of the respiratory system and mediastinum Vascular Endothelial Growth Factor A - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!