Insulin-like Growth Factor-binding Protein-5 Activates Plasminogen by Interaction with Tissue Plasminogen Activator, Independently of Its Ability to Bind to Plasminogen Activator Inhibitor-1, Insulin-like Growth Factor-I, or Heparin

Transgenic mice expressing IGFBP-5 in the mammary gland exhibit increased cell death and plasmin generation. Because IGFBP-5 has been reported to bind to plasminogen activator inhibitor-1 (PAI-1), we determined the effects of this interaction in HC11 cells. PAI-1 prevented plasmin generation from pl...

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Veröffentlicht in:	The Journal of biological chemistry 2006-04, Vol.281 (16), p.10883-10889
Hauptverfasser:	Sorrell, Alice M., Shand, John H., Tonner, Elizabeth, Gamberoni, Matteo, Accorsi, Pier A., Beattie, James, Allan, Gordon J., Flint, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques Carboxypeptidase B - metabolism Caspase 3 Caspases - metabolism Cell Death Cell Line Cell-Free System Chromatography, High Pressure Liquid Culture Media, Serum-Free - metabolism Escherichia coli - metabolism Fibrinolysin - metabolism Focal Adhesions - metabolism Glutathione Transferase - metabolism Heparin - metabolism Insulin-Like Growth Factor Binding Protein 5 - metabolism Insulin-Like Growth Factor Binding Protein 5 - physiology Insulin-Like Growth Factor I - metabolism Mice Mice, Transgenic Mutation Plasminogen - metabolism Plasminogen Activator Inhibitor 1 - metabolism Plasminogen Activators - metabolism Protein Structure, Tertiary Recombinant Fusion Proteins - metabolism Recombinant Proteins - metabolism Time Factors Tissue Plasminogen Activator - metabolism
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