Allosteric Modulation of Binding Properties between Units of Chemokine Receptor Homo- and Hetero-Oligomers

We have demonstrated previously that the chemokine receptors CCR2 and CCR5 form homo- and heterodimers and that dimers can only bind a single chemokine molecule with high affinity. We provide here evidence from bioluminescence resonance energy transfer experiments that stimulation by chemokines does...

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Veröffentlicht in:	Molecular pharmacology 2006-05, Vol.69 (5), p.1652-1661
Hauptverfasser:	Springael, Jean-Yves, Le Minh, Phu Nguyen, Urizar, Eneko, Costagliola, Sabine, Vassart, Gilbert, Parmentier, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Binding Sites Binding, Competitive Calcium Signaling CHO Cells Cricetinae Dimerization Kinetics Macromolecular Substances Receptors, Chemokine - chemistry Receptors, Chemokine - metabolism
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