Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): In vivo evaluation

A novel sustained-release (SR) system, disintegration-controlled matrix tablet (DCMT), was developed for poorly water-soluble drugs. DCMT, consisting of wax and solid dispersion (SD) granules containing a disintegrant, could control the release of nilvadipine (NiD), a model compound, by its disinteg...

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Veröffentlicht in:	Journal of controlled release 2006-05, Vol.112 (1), p.51-56
Hauptverfasser:	Tanaka, Nobuyuki, Imai, Keiji, Okimoto, Kazuto, Ueda, Satoshi, Tokunaga, Yuji, Ibuki, Rinta, Higaki, Kazutaka, Kimura, Toshikiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Oral Animals Biological and medical sciences Biological Availability Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacokinetics Chemistry, Pharmaceutical Delayed-Action Preparations Disintegration Dogs General pharmacology Hypromellose Derivatives Intestinal Absorption IVIVC Male Medical sciences Methylcellulose - analogs & derivatives Methylcellulose - chemistry Nifedipine - administration & dosage Nifedipine - analogs & derivatives Nifedipine - chemistry Nifedipine - pharmacokinetics Nilvadipine Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solid dispersion Solubility Soybean Oil - chemistry Sustained-release Tablets, Enteric-Coated Water - chemistry
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