Prognostic Value of HSP27 in Head and Neck Squamous Cell Carcinoma: a Retrospective Analysis of 57 Tumours
Background: The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma (OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC. Materials and Methods: The immunohistochemical expression of HSP27 was e...
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| Veröffentlicht in: | Anticancer research 2006-03, Vol.26 (2B), p.1343-1349 |
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| creator | MUZIO, Lorenzo Lo CAMPISI, Giuseppina FARINA, Antonio RUBINI, Corrado FERRARI, Francesca FALASCHINI, Silvia LEONARDI, Rosalia CARINCI, Francesco STALBANO, Stefania DE ROSA, Gaetano |
| description | Background: The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma
(OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC. Materials and Methods:
The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After
grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM,
staging and survival rate. Univariate and multivariate analyses were performed. Results: HSP27 was found to be reduced in
31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP27 immunolabelling did not show significant
differences in relation to any variables retrospectively considered. In terms of prognostic significance, HSP27 reduced expression
was found to have an independent association with the poorest overall survival rate (p=0.009; OR= 4.404; CI=1.444:13.427 by
Cox regression). Conclusion: HSP27 reduced expression is an early marker of poor prognosis, useful in identifying aggressive
biological behaviour in OSCC cases even before relapse. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67872108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17140894</sourcerecordid><originalsourceid>FETCH-LOGICAL-h301t-9460bd639dfe54504f204de172d33fa472eacdc71f4cafdf82dcc4633ccf9c8e3</originalsourceid><addsrcrecordid>eNqFkEtPwkAUhRujEUT_gpmN7prMqzOtO2xUTIgSQbfNZR4w2AfOtBr-vTViWLo6m-9-9-QcRUMiMxLLhOHjaIhpgmOJcTKIzkLYYCxElrLTaECEIFnC2TDazHyzqpvQOoXeoOwMaiyazGdUIlejiQGNoNboyah3NP_ooGq6gHJTligHr1zdVHCDAL2Y1jdha1TrPg0a11Duggs_rkSiRddf-XAenVgog7nY5yh6vb9b5JN4-vzwmI-n8Zph0sYZF3ipBcu0NQlPMLcUc22IpJoxC1xSA0orSSxXYLVNqVaKC8aUsplKDRtF17_erW8-OhPaonJB9ZWhNn37QshUUoLTf0EiCcdpxnvwcg92y8roYutdBX5X_M3YA1d7AIKC0nqolQsHTgqZiIwePq7dav3lvClCBWXZa1kBnoqC3haE9cJvmpuIzA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17140894</pqid></control><display><type>article</type><title>Prognostic Value of HSP27 in Head and Neck Squamous Cell Carcinoma: a Retrospective Analysis of 57 Tumours</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>MUZIO, Lorenzo Lo ; CAMPISI, Giuseppina ; FARINA, Antonio ; RUBINI, Corrado ; FERRARI, Francesca ; FALASCHINI, Silvia ; LEONARDI, Rosalia ; CARINCI, Francesco ; STALBANO, Stefania ; DE ROSA, Gaetano</creator><creatorcontrib>MUZIO, Lorenzo Lo ; CAMPISI, Giuseppina ; FARINA, Antonio ; RUBINI, Corrado ; FERRARI, Francesca ; FALASCHINI, Silvia ; LEONARDI, Rosalia ; CARINCI, Francesco ; STALBANO, Stefania ; DE ROSA, Gaetano</creatorcontrib><description>Background: The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma
(OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC. Materials and Methods:
The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After
grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM,
staging and survival rate. Univariate and multivariate analyses were performed. Results: HSP27 was found to be reduced in
31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP27 immunolabelling did not show significant
differences in relation to any variables retrospectively considered. In terms of prognostic significance, HSP27 reduced expression
was found to have an independent association with the poorest overall survival rate (p=0.009; OR= 4.404; CI=1.444:13.427 by
Cox regression). Conclusion: HSP27 reduced expression is an early marker of poor prognosis, useful in identifying aggressive
biological behaviour in OSCC cases even before relapse.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16619543</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Female ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - pathology ; Heat-Shock Proteins - biosynthesis ; Humans ; Immunohistochemistry ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Prognosis ; Retrospective Studies ; Survival Rate ; Tumors</subject><ispartof>Anticancer research, 2006-03, Vol.26 (2B), p.1343-1349</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17675692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16619543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MUZIO, Lorenzo Lo</creatorcontrib><creatorcontrib>CAMPISI, Giuseppina</creatorcontrib><creatorcontrib>FARINA, Antonio</creatorcontrib><creatorcontrib>RUBINI, Corrado</creatorcontrib><creatorcontrib>FERRARI, Francesca</creatorcontrib><creatorcontrib>FALASCHINI, Silvia</creatorcontrib><creatorcontrib>LEONARDI, Rosalia</creatorcontrib><creatorcontrib>CARINCI, Francesco</creatorcontrib><creatorcontrib>STALBANO, Stefania</creatorcontrib><creatorcontrib>DE ROSA, Gaetano</creatorcontrib><title>Prognostic Value of HSP27 in Head and Neck Squamous Cell Carcinoma: a Retrospective Analysis of 57 Tumours</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma
(OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC. Materials and Methods:
The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After
grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM,
staging and survival rate. Univariate and multivariate analyses were performed. Results: HSP27 was found to be reduced in
31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP27 immunolabelling did not show significant
differences in relation to any variables retrospectively considered. In terms of prognostic significance, HSP27 reduced expression
was found to have an independent association with the poorest overall survival rate (p=0.009; OR= 4.404; CI=1.444:13.427 by
Cox regression). Conclusion: HSP27 reduced expression is an early marker of poor prognosis, useful in identifying aggressive
biological behaviour in OSCC cases even before relapse.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Female</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Heat-Shock Proteins - biosynthesis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwkAUhRujEUT_gpmN7prMqzOtO2xUTIgSQbfNZR4w2AfOtBr-vTViWLo6m-9-9-QcRUMiMxLLhOHjaIhpgmOJcTKIzkLYYCxElrLTaECEIFnC2TDazHyzqpvQOoXeoOwMaiyazGdUIlejiQGNoNboyah3NP_ooGq6gHJTligHr1zdVHCDAL2Y1jdha1TrPg0a11Duggs_rkSiRddf-XAenVgog7nY5yh6vb9b5JN4-vzwmI-n8Zph0sYZF3ipBcu0NQlPMLcUc22IpJoxC1xSA0orSSxXYLVNqVaKC8aUsplKDRtF17_erW8-OhPaonJB9ZWhNn37QshUUoLTf0EiCcdpxnvwcg92y8roYutdBX5X_M3YA1d7AIKC0nqolQsHTgqZiIwePq7dav3lvClCBWXZa1kBnoqC3haE9cJvmpuIzA</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>MUZIO, Lorenzo Lo</creator><creator>CAMPISI, Giuseppina</creator><creator>FARINA, Antonio</creator><creator>RUBINI, Corrado</creator><creator>FERRARI, Francesca</creator><creator>FALASCHINI, Silvia</creator><creator>LEONARDI, Rosalia</creator><creator>CARINCI, Francesco</creator><creator>STALBANO, Stefania</creator><creator>DE ROSA, Gaetano</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Prognostic Value of HSP27 in Head and Neck Squamous Cell Carcinoma: a Retrospective Analysis of 57 Tumours</title><author>MUZIO, Lorenzo Lo ; CAMPISI, Giuseppina ; FARINA, Antonio ; RUBINI, Corrado ; FERRARI, Francesca ; FALASCHINI, Silvia ; LEONARDI, Rosalia ; CARINCI, Francesco ; STALBANO, Stefania ; DE ROSA, Gaetano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-9460bd639dfe54504f204de172d33fa472eacdc71f4cafdf82dcc4633ccf9c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Female</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Heat-Shock Proteins - biosynthesis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MUZIO, Lorenzo Lo</creatorcontrib><creatorcontrib>CAMPISI, Giuseppina</creatorcontrib><creatorcontrib>FARINA, Antonio</creatorcontrib><creatorcontrib>RUBINI, Corrado</creatorcontrib><creatorcontrib>FERRARI, Francesca</creatorcontrib><creatorcontrib>FALASCHINI, Silvia</creatorcontrib><creatorcontrib>LEONARDI, Rosalia</creatorcontrib><creatorcontrib>CARINCI, Francesco</creatorcontrib><creatorcontrib>STALBANO, Stefania</creatorcontrib><creatorcontrib>DE ROSA, Gaetano</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MUZIO, Lorenzo Lo</au><au>CAMPISI, Giuseppina</au><au>FARINA, Antonio</au><au>RUBINI, Corrado</au><au>FERRARI, Francesca</au><au>FALASCHINI, Silvia</au><au>LEONARDI, Rosalia</au><au>CARINCI, Francesco</au><au>STALBANO, Stefania</au><au>DE ROSA, Gaetano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of HSP27 in Head and Neck Squamous Cell Carcinoma: a Retrospective Analysis of 57 Tumours</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>26</volume><issue>2B</issue><spage>1343</spage><epage>1349</epage><pages>1343-1349</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma
(OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC. Materials and Methods:
The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After
grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM,
staging and survival rate. Univariate and multivariate analyses were performed. Results: HSP27 was found to be reduced in
31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP27 immunolabelling did not show significant
differences in relation to any variables retrospectively considered. In terms of prognostic significance, HSP27 reduced expression
was found to have an independent association with the poorest overall survival rate (p=0.009; OR= 4.404; CI=1.444:13.427 by
Cox regression). Conclusion: HSP27 reduced expression is an early marker of poor prognosis, useful in identifying aggressive
biological behaviour in OSCC cases even before relapse.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16619543</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Female Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Heat-Shock Proteins - biosynthesis Humans Immunohistochemistry Logistic Models Male Medical sciences Middle Aged Neoplasm Staging Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Prognosis Retrospective Studies Survival Rate Tumors |
| title | Prognostic Value of HSP27 in Head and Neck Squamous Cell Carcinoma: a Retrospective Analysis of 57 Tumours |
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