Family-based designs in the age of large-scale gene-association studies

Key Points Either population-based or family-based designs can be used in gene-association studies. Population-based designs use unrelated individuals; family-based designs use probands and their relatives, typically either parents or siblings. Genetic-association studies face the obstacles of popul...

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Veröffentlicht in:	Nature reviews. Genetics 2006-05, Vol.7 (5), p.385-394
Hauptverfasser:	Laird, Nan M, Lange, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Disease Family Fundamental and applied biological sciences. Psychology Gene Function Genes Genetic Techniques Genetics of eukaryotes. Biological and molecular evolution Genetics, Population Genome, Human Genomes Haplotypes Human Genetics Humans Hypotheses Hypothesis testing Linkage Disequilibrium Models, Genetic Parents & parenting Pedigree Phenotype Population-based studies Quantitative Trait, Heritable review-article Statistical power
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