Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model

Structural in addition to electrical remodeling may be induced by persistent atrial fibrillation per se and make atrial fibrillation refractory to antiarrhythmic drug therapy. Matrix metalloproteinases (MMPs) contribute to structural remodeling in the interstitial space. Amiodarone is effective in t...

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Veröffentlicht in:	European journal of pharmacology 2006-04, Vol.536 (1), p.148-153
Hauptverfasser:	Ashikaga, Keiichi, Kobayashi, Takao, Kimura, Masaomi, Owada, Shingen, Sasaki, Shingo, Iwasa, Atsushi, Furukawa, Ken-ichi, Motomura, Shigeru, Okumura, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Administration, Oral Amiodarone Amiodarone - administration & dosage Amiodarone - therapeutic use Animals Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - therapeutic use Atrial fibrillation Atrial Fibrillation - etiology Atrial Fibrillation - physiopathology Atrial Fibrillation - prevention & control Biological and medical sciences Cardiac dysrhythmias Cardiac Pacing, Artificial - adverse effects Cardiac Pacing, Artificial - methods Cardiology. Vascular system Disease Models, Animal Dog Diseases - etiology Dog Diseases - physiopathology Dog Diseases - prevention & control Dogs Electrical remodeling Fibrosis Heart Heart Atria - drug effects Heart Atria - metabolism Heart Atria - pathology Heart Conduction System - drug effects Heart Conduction System - physiopathology Heart Ventricles - drug effects Heart Ventricles - physiopathology Humans Immunoblotting Matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Medical sciences Pharmacology. Drug treatments Structural remodeling Ventricular Remodeling - drug effects
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