Physical Activity and Survival After Breast Cancer Diagnosis
CONTEXT Physical activity has been shown to decrease the incidence of breast cancer, but the effect on recurrence or survival after a breast cancer diagnosis is not known. OBJECTIVE To determine whether physical activity among women with breast cancer decreases their risk of death from breast cancer...
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| Veröffentlicht in: | JAMA : the journal of the American Medical Association 2005-05, Vol.293 (20), p.2479-2486 |
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| container_title | JAMA : the journal of the American Medical Association |
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| creator | Holmes, Michelle D Chen, Wendy Y Feskanich, Diane Kroenke, Candyce H Colditz, Graham A |
| description | CONTEXT Physical activity has been shown to decrease the incidence of breast
cancer, but the effect on recurrence or survival after a breast cancer diagnosis
is not known. OBJECTIVE To determine whether physical activity among women with breast cancer
decreases their risk of death from breast cancer compared with more sedentary
women. DESIGN, SETTING, AND PARTICIPANTS Prospective observational study based on responses from 2987 female
registered nurses in the Nurses’ Health Study who were diagnosed with
stage I, II, or III breast cancer between 1984 and 1998 and who were followed
up until death or June 2002, whichever came first. MAIN OUTCOME MEASURE Breast cancer mortality risk according to physical activity category
( |
| doi_str_mv | 10.1001/jama.293.20.2479 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67869969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>200955</ama_id><sourcerecordid>67869969</sourcerecordid><originalsourceid>FETCH-LOGICAL-a428t-8fc53018689048317b15925aae46dd47e58388453e48c9655000cc32a7b090f33</originalsourceid><addsrcrecordid>eNqF0UlLAzEYBuAgiq3Vu15kEPQ2Y_YFvNS6QkFBPQ9pJqMps7TJTKH_3kirghdzCcn3kOX9ADhGMEMQosu5rnWGFckwzDAVagcMESMyJUzJXTCEUMlUUEkH4CCEOYwDEbEPBogpRGNhCK6eP9bBGV0lY9O5levWiW6K5KX3K7f62i0765Nrb3XokoluTFzdOP3etMGFQ7BX6irYo-08Am93t6-Th3T6dP84GU9TTbHsUlkaRiCSXCpIJUFiFu_HTGtLeVFQYZkkUlJGLJVGccbiO40hWIsZVLAkZAQuNucufLvsbejy2gVjq0o3tu1DzoXkSnH1L0SCcEiZiPDsD5y3vW_iJ3KMEI1GwYhOt6if1bbIF97V2q_z7_QiON8CHWKEpY_5uPDrBGKUMx7dycbFdv1UcewOY-QTNYGDVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211404590</pqid></control><display><type>article</type><title>Physical Activity and Survival After Breast Cancer Diagnosis</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Holmes, Michelle D ; Chen, Wendy Y ; Feskanich, Diane ; Kroenke, Candyce H ; Colditz, Graham A</creator><creatorcontrib>Holmes, Michelle D ; Chen, Wendy Y ; Feskanich, Diane ; Kroenke, Candyce H ; Colditz, Graham A</creatorcontrib><description>CONTEXT Physical activity has been shown to decrease the incidence of breast
cancer, but the effect on recurrence or survival after a breast cancer diagnosis
is not known. OBJECTIVE To determine whether physical activity among women with breast cancer
decreases their risk of death from breast cancer compared with more sedentary
women. DESIGN, SETTING, AND PARTICIPANTS Prospective observational study based on responses from 2987 female
registered nurses in the Nurses’ Health Study who were diagnosed with
stage I, II, or III breast cancer between 1984 and 1998 and who were followed
up until death or June 2002, whichever came first. MAIN OUTCOME MEASURE Breast cancer mortality risk according to physical activity category
(<3, 3-8.9, 9-14.9, 15-23.9, or ≥24 metabolic equivalent task [MET]
hours per week). RESULTS Compared with women who engaged in less than 3 MET-hours per week of
physical activity, the adjusted relative risk (RR) of death from breast cancer
was 0.80 (95% confidence interval [CI], 0.60-1.06) for 3 to 8.9 MET-hours
per week; 0.50 (95% CI, 0.31-0.82) for 9 to 14.9 MET-hours per week; 0.56
(95% CI, 0.38-0.84) for 15 to 23.9 MET-hours per week; and 0.60 (95% CI, 0.40-0.89)
for 24 or more MET-hours per week (P for trend =
.004). Three MET-hours is equivalent to walking at average pace of 2 to 2.9
mph for 1 hour. The benefit of physical activity was particularly apparent
among women with hormone-responsive tumors. The RR of breast cancer death
for women with hormone-responsive tumors who engaged in 9 or more MET-hours
per week of activity compared with women with hormone-responsive tumors who
engaged in less than 9 MET-hours per week was 0.50 (95% CI, 0.34-0.74). Compared
with women who engaged in less than 3 MET-hours per week of activity, the
absolute unadjusted mortality risk reduction was 6% at 10 years for women
who engaged in 9 or more MET-hours per week. CONCLUSIONS Physical activity after a breast cancer diagnosis may reduce the risk
of death from this disease. The greatest benefit occurred in women who performed
the equivalent of walking 3 to 5 hours per week at an average pace, with little
evidence of a correlation between increased benefit and greater energy expenditure.
Women with breast cancer who follow US physical activity recommendations may
improve their survival.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.293.20.2479</identifier><identifier>PMID: 15914748</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Biological and medical sciences ; Breast cancer ; Breast Neoplasms - mortality ; Exercise ; Female ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical diagnosis ; Medical sciences ; Mortality ; Physical fitness ; Prevention programs ; Proportional Hazards Models ; Prospective Studies ; Survival Analysis ; Tumors</subject><ispartof>JAMA : the journal of the American Medical Association, 2005-05, Vol.293 (20), p.2479-2486</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Medical Association May 25, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a428t-8fc53018689048317b15925aae46dd47e58388453e48c9655000cc32a7b090f33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jama/articlepdf/10.1001/jama.293.20.2479$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.293.20.2479$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,780,784,3340,27924,27925,76489,76492</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17154656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15914748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmes, Michelle D</creatorcontrib><creatorcontrib>Chen, Wendy Y</creatorcontrib><creatorcontrib>Feskanich, Diane</creatorcontrib><creatorcontrib>Kroenke, Candyce H</creatorcontrib><creatorcontrib>Colditz, Graham A</creatorcontrib><title>Physical Activity and Survival After Breast Cancer Diagnosis</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>CONTEXT Physical activity has been shown to decrease the incidence of breast
cancer, but the effect on recurrence or survival after a breast cancer diagnosis
is not known. OBJECTIVE To determine whether physical activity among women with breast cancer
decreases their risk of death from breast cancer compared with more sedentary
women. DESIGN, SETTING, AND PARTICIPANTS Prospective observational study based on responses from 2987 female
registered nurses in the Nurses’ Health Study who were diagnosed with
stage I, II, or III breast cancer between 1984 and 1998 and who were followed
up until death or June 2002, whichever came first. MAIN OUTCOME MEASURE Breast cancer mortality risk according to physical activity category
(<3, 3-8.9, 9-14.9, 15-23.9, or ≥24 metabolic equivalent task [MET]
hours per week). RESULTS Compared with women who engaged in less than 3 MET-hours per week of
physical activity, the adjusted relative risk (RR) of death from breast cancer
was 0.80 (95% confidence interval [CI], 0.60-1.06) for 3 to 8.9 MET-hours
per week; 0.50 (95% CI, 0.31-0.82) for 9 to 14.9 MET-hours per week; 0.56
(95% CI, 0.38-0.84) for 15 to 23.9 MET-hours per week; and 0.60 (95% CI, 0.40-0.89)
for 24 or more MET-hours per week (P for trend =
.004). Three MET-hours is equivalent to walking at average pace of 2 to 2.9
mph for 1 hour. The benefit of physical activity was particularly apparent
among women with hormone-responsive tumors. The RR of breast cancer death
for women with hormone-responsive tumors who engaged in 9 or more MET-hours
per week of activity compared with women with hormone-responsive tumors who
engaged in less than 9 MET-hours per week was 0.50 (95% CI, 0.34-0.74). Compared
with women who engaged in less than 3 MET-hours per week of activity, the
absolute unadjusted mortality risk reduction was 6% at 10 years for women
who engaged in 9 or more MET-hours per week. CONCLUSIONS Physical activity after a breast cancer diagnosis may reduce the risk
of death from this disease. The greatest benefit occurred in women who performed
the equivalent of walking 3 to 5 hours per week at an average pace, with little
evidence of a correlation between increased benefit and greater energy expenditure.
Women with breast cancer who follow US physical activity recommendations may
improve their survival.</description><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - mortality</subject><subject>Exercise</subject><subject>Female</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Physical fitness</subject><subject>Prevention programs</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UlLAzEYBuAgiq3Vu15kEPQ2Y_YFvNS6QkFBPQ9pJqMps7TJTKH_3kirghdzCcn3kOX9ADhGMEMQosu5rnWGFckwzDAVagcMESMyJUzJXTCEUMlUUEkH4CCEOYwDEbEPBogpRGNhCK6eP9bBGV0lY9O5levWiW6K5KX3K7f62i0765Nrb3XokoluTFzdOP3etMGFQ7BX6irYo-08Am93t6-Th3T6dP84GU9TTbHsUlkaRiCSXCpIJUFiFu_HTGtLeVFQYZkkUlJGLJVGccbiO40hWIsZVLAkZAQuNucufLvsbejy2gVjq0o3tu1DzoXkSnH1L0SCcEiZiPDsD5y3vW_iJ3KMEI1GwYhOt6if1bbIF97V2q_z7_QiON8CHWKEpY_5uPDrBGKUMx7dycbFdv1UcewOY-QTNYGDVg</recordid><startdate>20050525</startdate><enddate>20050525</enddate><creator>Holmes, Michelle D</creator><creator>Chen, Wendy Y</creator><creator>Feskanich, Diane</creator><creator>Kroenke, Candyce H</creator><creator>Colditz, Graham A</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050525</creationdate><title>Physical Activity and Survival After Breast Cancer Diagnosis</title><author>Holmes, Michelle D ; Chen, Wendy Y ; Feskanich, Diane ; Kroenke, Candyce H ; Colditz, Graham A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a428t-8fc53018689048317b15925aae46dd47e58388453e48c9655000cc32a7b090f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - mortality</topic><topic>Exercise</topic><topic>Female</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Physical fitness</topic><topic>Prevention programs</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmes, Michelle D</creatorcontrib><creatorcontrib>Chen, Wendy Y</creatorcontrib><creatorcontrib>Feskanich, Diane</creatorcontrib><creatorcontrib>Kroenke, Candyce H</creatorcontrib><creatorcontrib>Colditz, Graham A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmes, Michelle D</au><au>Chen, Wendy Y</au><au>Feskanich, Diane</au><au>Kroenke, Candyce H</au><au>Colditz, Graham A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical Activity and Survival After Breast Cancer Diagnosis</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>2005-05-25</date><risdate>2005</risdate><volume>293</volume><issue>20</issue><spage>2479</spage><epage>2486</epage><pages>2479-2486</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>CONTEXT Physical activity has been shown to decrease the incidence of breast
cancer, but the effect on recurrence or survival after a breast cancer diagnosis
is not known. OBJECTIVE To determine whether physical activity among women with breast cancer
decreases their risk of death from breast cancer compared with more sedentary
women. DESIGN, SETTING, AND PARTICIPANTS Prospective observational study based on responses from 2987 female
registered nurses in the Nurses’ Health Study who were diagnosed with
stage I, II, or III breast cancer between 1984 and 1998 and who were followed
up until death or June 2002, whichever came first. MAIN OUTCOME MEASURE Breast cancer mortality risk according to physical activity category
(<3, 3-8.9, 9-14.9, 15-23.9, or ≥24 metabolic equivalent task [MET]
hours per week). RESULTS Compared with women who engaged in less than 3 MET-hours per week of
physical activity, the adjusted relative risk (RR) of death from breast cancer
was 0.80 (95% confidence interval [CI], 0.60-1.06) for 3 to 8.9 MET-hours
per week; 0.50 (95% CI, 0.31-0.82) for 9 to 14.9 MET-hours per week; 0.56
(95% CI, 0.38-0.84) for 15 to 23.9 MET-hours per week; and 0.60 (95% CI, 0.40-0.89)
for 24 or more MET-hours per week (P for trend =
.004). Three MET-hours is equivalent to walking at average pace of 2 to 2.9
mph for 1 hour. The benefit of physical activity was particularly apparent
among women with hormone-responsive tumors. The RR of breast cancer death
for women with hormone-responsive tumors who engaged in 9 or more MET-hours
per week of activity compared with women with hormone-responsive tumors who
engaged in less than 9 MET-hours per week was 0.50 (95% CI, 0.34-0.74). Compared
with women who engaged in less than 3 MET-hours per week of activity, the
absolute unadjusted mortality risk reduction was 6% at 10 years for women
who engaged in 9 or more MET-hours per week. CONCLUSIONS Physical activity after a breast cancer diagnosis may reduce the risk
of death from this disease. The greatest benefit occurred in women who performed
the equivalent of walking 3 to 5 hours per week at an average pace, with little
evidence of a correlation between increased benefit and greater energy expenditure.
Women with breast cancer who follow US physical activity recommendations may
improve their survival.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>15914748</pmid><doi>10.1001/jama.293.20.2479</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 2005-05, Vol.293 (20), p.2479-2486 |
| issn | 0098-7484 1538-3598 |
| language | eng |
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| source | MEDLINE; American Medical Association Journals |
| subjects | Biological and medical sciences Breast cancer Breast Neoplasms - mortality Exercise Female General aspects Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical diagnosis Medical sciences Mortality Physical fitness Prevention programs Proportional Hazards Models Prospective Studies Survival Analysis Tumors |
| title | Physical Activity and Survival After Breast Cancer Diagnosis |
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