Corticotropin‐releasing factor 1 receptor‐mediated mechanisms inhibit colonic hypersensitivity in rats

The potential relationship between stress and irritable bowel syndrome (IBS) symptomatology suggests a possible role for stress‐mediating hormones, such as corticotropin‐releasing factor (CRF), in the altered perception of stimuli in IBS patients. In previous studies, Wistar–Kyoto (WKY) rats with ge...

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Veröffentlicht in:	Neurogastroenterology and motility 2005-06, Vol.17 (3), p.415-422
Hauptverfasser:	Greenwood‐van Meerveld, B., Johnson, A. C., Cochrane, S., Schulkin, J., Myers, D. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antalarmin Anxiety - physiopathology colon Colon - innervation Colon - physiology Colonic Diseases - drug therapy Colonic Diseases - physiopathology corticotropin releasing factor Corticotropin-Releasing Hormone - physiology Hormone Antagonists - pharmacology Irritable Bowel Syndrome - drug therapy Irritable Bowel Syndrome - physiopathology Physical Stimulation Pyrimidines - pharmacology Pyrroles - pharmacology Rats Rats, Inbred F344 Rats, Inbred WKY Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - physiology Reflex - physiology Species Specificity
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