Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning
In a screen to identify factors that regulate the conversion of mesenchyme to epithelium during the early stages of nephrogenesis, it was found that the Smad4-interacting transcriptional cofactor, Cited1, is expressed in the condensed cap mesenchyme surrounding the tip of the ureteric bud (UB), is d...
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| Veröffentlicht in: | Journal of the American Society of Nephrology 2005-06, Vol.16 (6), p.1632-1644 |
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| container_issue | 6 |
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| container_title | Journal of the American Society of Nephrology |
| container_volume | 16 |
| creator | Plisov, Sergey Tsang, Michael Shi, Genbin Boyle, Scott Yoshino, Kiyoshi Dunwoodie, Sally L Dawid, Igor B Shioda, Toshi Perantoni, Alan O de Caestecker, Mark P |
| description | In a screen to identify factors that regulate the conversion of mesenchyme to epithelium during the early stages of nephrogenesis, it was found that the Smad4-interacting transcriptional cofactor, Cited1, is expressed in the condensed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiation into epithelia, and has the capacity to block UB branching and epithelial morphogenesis in cultured metanephroi. Cited1 represses Wnt/beta-catenin but activates Smad4-dependent transcription involved in TGF-beta and Bmp signaling. By modifying these pathways, Cited1 may coordinate cellular differentiation and survival signals that regulate nephronic patterning in the metanephros. |
| doi_str_mv | 10.1681/ASN.2004060476 |
| format | Article |
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Cited1 represses Wnt/beta-catenin but activates Smad4-dependent transcription involved in TGF-beta and Bmp signaling. 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| issn | 1046-6673 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals beta Catenin Cell Differentiation Cell Survival Cytoskeletal Proteins - physiology DNA-Binding Proteins - physiology Epithelium Intercellular Signaling Peptides and Proteins - physiology Kidney - embryology Kidney - physiology Nuclear Proteins - physiology Organogenesis - physiology Rats Signal Transduction Smad4 Protein Trans-Activators - physiology Transcription, Genetic Transforming Growth Factor beta - physiology Wnt Proteins |
| title | Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning |
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