Changes in Collagen Orientation and Distribution in Keratoconus Corneas
To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons. Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional map...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2005-06, Vol.46 (6), p.1948-1956 |
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| container_end_page | 1956 |
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| container_issue | 6 |
| container_start_page | 1948 |
| container_title | Investigative ophthalmology & visual science |
| container_volume | 46 |
| creator | Meek, Keith M Tuft, Stephen J Huang, Yifei Gill, Paulvinder S Hayes, Sally Newton, Richard H Bron, Anthony J |
| description | To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons.
Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional maps of the orientation of the lamellae and of the distribution of total and preferentially aligned lamellae.
Compared with normal corneas, in keratoconus the gross organization of the stromal lamellae was dramatically changed, and the collagen fibrillar mass was unevenly distributed, particularly around the presumed apex of the cone.
The development of keratoconus involves a high degree of inter- and probably intralamellar displacement and slippage that leads to thinning of the central cornea and associated changes in corneal curvature. This slippage may be promoted by a loss of cohesive forces and mechanical failure in regions where lamellae bifurcate. |
| doi_str_mv | 10.1167/iovs.04-1253 |
| format | Article |
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Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional maps of the orientation of the lamellae and of the distribution of total and preferentially aligned lamellae.
Compared with normal corneas, in keratoconus the gross organization of the stromal lamellae was dramatically changed, and the collagen fibrillar mass was unevenly distributed, particularly around the presumed apex of the cone.
The development of keratoconus involves a high degree of inter- and probably intralamellar displacement and slippage that leads to thinning of the central cornea and associated changes in corneal curvature. This slippage may be promoted by a loss of cohesive forces and mechanical failure in regions where lamellae bifurcate.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.04-1253</identifier><identifier>PMID: 15914608</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Collagen - chemistry ; Collagen - metabolism ; Corneal Stroma - chemistry ; Corneal Stroma - metabolism ; Corneal Stroma - ultrastructure ; Diseases of cornea, anterior segment and sclera ; Humans ; Keratoconus - metabolism ; Keratoconus - pathology ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; X-Ray Diffraction</subject><ispartof>Investigative ophthalmology & visual science, 2005-06, Vol.46 (6), p.1948-1956</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-56486dc78f039cdf95f66c2691f6d8354e2720ca922723577853ce62794a235d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16816138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15914608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meek, Keith M</creatorcontrib><creatorcontrib>Tuft, Stephen J</creatorcontrib><creatorcontrib>Huang, Yifei</creatorcontrib><creatorcontrib>Gill, Paulvinder S</creatorcontrib><creatorcontrib>Hayes, Sally</creatorcontrib><creatorcontrib>Newton, Richard H</creatorcontrib><creatorcontrib>Bron, Anthony J</creatorcontrib><title>Changes in Collagen Orientation and Distribution in Keratoconus Corneas</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons.
Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional maps of the orientation of the lamellae and of the distribution of total and preferentially aligned lamellae.
Compared with normal corneas, in keratoconus the gross organization of the stromal lamellae was dramatically changed, and the collagen fibrillar mass was unevenly distributed, particularly around the presumed apex of the cone.
The development of keratoconus involves a high degree of inter- and probably intralamellar displacement and slippage that leads to thinning of the central cornea and associated changes in corneal curvature. This slippage may be promoted by a loss of cohesive forces and mechanical failure in regions where lamellae bifurcate.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Collagen - chemistry</subject><subject>Collagen - metabolism</subject><subject>Corneal Stroma - chemistry</subject><subject>Corneal Stroma - metabolism</subject><subject>Corneal Stroma - ultrastructure</subject><subject>Diseases of cornea, anterior segment and sclera</subject><subject>Humans</subject><subject>Keratoconus - metabolism</subject><subject>Keratoconus - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>X-Ray Diffraction</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1PwzAQxS0EoqWwMaMsMJHibzsjKlAQlbrAbLmO0xolTrETKv57XBqp09Pd_e7p6QFwjeAUIS4eXPsTp5DmCDNyAsaIMZwzIckpGENEeQ4ppCNwEeMXhBghDM_BCLEinaAcg_lso_3axsz5bNbWtV5bny2Ds77TnWt9pn2ZPbnYBbfq_xcJfLdBd61pfR_TU_BWx0twVuk62qtBJ-Dz5flj9povlvO32eMiN5SgLmecSl4aIStIClNWBas4N5gXqOKlJIxaLDA0usBJCRNCMmIsx6KgOs0lmYC7g-82tN-9jZ1qXDQ2Bfe27aPiQnIpoEjg_QE0oY0x2Eptg2t0-FUIqn1xal-cglTti0v4zeDbrxpbHuGhqQTcDoCORtdV0N64eOS4RBwReQy4cevNzgWrYqPrOtkitdvtKFdcoYJK8gfgy4Jl</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Meek, Keith M</creator><creator>Tuft, Stephen J</creator><creator>Huang, Yifei</creator><creator>Gill, Paulvinder S</creator><creator>Hayes, Sally</creator><creator>Newton, Richard H</creator><creator>Bron, Anthony J</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Changes in Collagen Orientation and Distribution in Keratoconus Corneas</title><author>Meek, Keith M ; Tuft, Stephen J ; Huang, Yifei ; Gill, Paulvinder S ; Hayes, Sally ; Newton, Richard H ; Bron, Anthony J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-56486dc78f039cdf95f66c2691f6d8354e2720ca922723577853ce62794a235d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Collagen - chemistry</topic><topic>Collagen - metabolism</topic><topic>Corneal Stroma - chemistry</topic><topic>Corneal Stroma - metabolism</topic><topic>Corneal Stroma - ultrastructure</topic><topic>Diseases of cornea, anterior segment and sclera</topic><topic>Humans</topic><topic>Keratoconus - metabolism</topic><topic>Keratoconus - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meek, Keith M</creatorcontrib><creatorcontrib>Tuft, Stephen J</creatorcontrib><creatorcontrib>Huang, Yifei</creatorcontrib><creatorcontrib>Gill, Paulvinder S</creatorcontrib><creatorcontrib>Hayes, Sally</creatorcontrib><creatorcontrib>Newton, Richard H</creatorcontrib><creatorcontrib>Bron, Anthony J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meek, Keith M</au><au>Tuft, Stephen J</au><au>Huang, Yifei</au><au>Gill, Paulvinder S</au><au>Hayes, Sally</au><au>Newton, Richard H</au><au>Bron, Anthony J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Collagen Orientation and Distribution in Keratoconus Corneas</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>46</volume><issue>6</issue><spage>1948</spage><epage>1956</epage><pages>1948-1956</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To map the collagen orientation and relative distribution of collagen fibrillar mass in keratoconus corneal buttons.
Structural analysis was performed by obtaining synchrotron x-ray scattering patterns across the samples at 0.25-mm intervals. The patterns were analyzed to produce two-dimensional maps of the orientation of the lamellae and of the distribution of total and preferentially aligned lamellae.
Compared with normal corneas, in keratoconus the gross organization of the stromal lamellae was dramatically changed, and the collagen fibrillar mass was unevenly distributed, particularly around the presumed apex of the cone.
The development of keratoconus involves a high degree of inter- and probably intralamellar displacement and slippage that leads to thinning of the central cornea and associated changes in corneal curvature. This slippage may be promoted by a loss of cohesive forces and mechanical failure in regions where lamellae bifurcate.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>15914608</pmid><doi>10.1167/iovs.04-1253</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Collagen - chemistry Collagen - metabolism Corneal Stroma - chemistry Corneal Stroma - metabolism Corneal Stroma - ultrastructure Diseases of cornea, anterior segment and sclera Humans Keratoconus - metabolism Keratoconus - pathology Male Medical sciences Middle Aged Ophthalmology X-Ray Diffraction |
| title | Changes in Collagen Orientation and Distribution in Keratoconus Corneas |
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