Relationship between contrast enhancement on fluid-attenuated inversion recovery MR sequences and signal intensity on T2-weighted MR images: Visual evaluation of brain tumors
Purpose To investigate the relationship between the degree of contrast enhancement in fluid‐attenuated inversion recovery (FLAIR) sequences and tumor signal intensity on T2‐weighted images. Materials and Methods A total of 96 patients suspected of having brain tumors were examined by MR imaging, and...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2005-06, Vol.21 (6), p.694-700 |
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| creator | Kubota, Takao Yamada, Kei Kizu, Osamu Hirota, Tatsuya Ito, Hirotoshi Ishihara, Kiyoshi Nishimura, Tsunehiko |
| description | Purpose
To investigate the relationship between the degree of contrast enhancement in fluid‐attenuated inversion recovery (FLAIR) sequences and tumor signal intensity on T2‐weighted images.
Materials and Methods
A total of 96 patients suspected of having brain tumors were examined by MR imaging, and whenever a brain tumor with an enhancing part larger than the slice thickness was demonstrated on postcontrast T1‐weighted images, postcontrast FLAIR images were additionally acquired. The tumor signal intensity on the T2‐weighted images was visually classified as follows: equal or lower compared with normal cerebral cortex (group 1), higher than normal cortex (group 2), and as high as cerebrospinal fluid (CSF) (group 3). When a lesion contained several parts with different signal intensities on T2‐weighted images, we assessed each part separately. In each group, we visually compared pre‐ and postcontrast FLAIR images and assessed whether tumor contrast enhancement was present. When contrast enhancement was present on FLAIR sequence, the degree of contrast enhancement in T1‐weighted and FLAIR sequences was visually compared.
Results
Postcontrast T1‐weighted images showed 46 enhancing lesions, including 48 parts, in 31 MR examinations. FLAIR images of the lesion‐parts in group 1 (N = 18) did not show significant contrast enhancement. In group 2 (N = 12), all the parts were enhanced in FLAIR sequences, and three parts were enhanced more clearly in the FLAIR sequences than in the T1‐weighted sequences. In group 3 (N = 18), all the parts were enhanced equally or more clearly in the FLAIR sequences than in the T1‐weighted sequences.
Conclusion
The signal intensity in FLAIR sequences is largely influenced by both T1 and T2 relaxation time; there is a close relationship between the signal intensity of brain tumors on T2‐weighted images and the degree of contrast enhancement on FLAIR sequences. When tumors have higher signal intensity than normal cortex on T2‐weighted images, additional postcontrast FLAIR imaging may improve their depiction. J. Magn. Reson. Imaging 2005;21:694–700. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.20331 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67868659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19412040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4321-76a12db143ab44b38a956170987ebe50621246e841ac8f7b0a3f9e8da9b2a6a23</originalsourceid><addsrcrecordid>eNqFkctu00AUhi0Eojc2PACaFQskl7l5bLNDFfSiNEhpAInN6Ng-TqbY4zAzbpqX4hmZNAF27WrO4vt-za8_SV4zesoo5e9ve2dOORWCPUsOWcZ5yrNCPY83zUTKCpofJEfe31JKy1JmL5MDlpVUCSkOk98z7CCYwfqlWZEKwxrRknqwwYEPBO0SbI092kAGS9puNE0KIaAdIWBDjL1D56NOHNZDvDfkekY8_hoxap6AbYg3CwtdRKPlTdhsg-Y8XaNZLLcZUTA9LNB_IN-MHyOKd9CND78iQ0sqB8aSMPaD8yfJixY6j6_273Hy9fOn-dlFOvlyfnn2cZLWUnCW5goYbyomBVRSVqKAMlMsp2WRY4UZVZxxqbCQDOqizSsKoi2xaKCsOCjg4jh5u8tduSF28UH3xtfYdWBxGL1WeaEKlZVPgqyUjFNJI_huB9Zu8N5hq1cu1nYbzajezqi3M-qHGSP8Zp86Vj02_9H9bhFgO2BtOtw8EqWvrmeXf0PTnWN8wPt_DrifsY7IM_19eq5vLqZX0x-TuabiD3qXuzM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19412040</pqid></control><display><type>article</type><title>Relationship between contrast enhancement on fluid-attenuated inversion recovery MR sequences and signal intensity on T2-weighted MR images: Visual evaluation of brain tumors</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Free Content</source><creator>Kubota, Takao ; Yamada, Kei ; Kizu, Osamu ; Hirota, Tatsuya ; Ito, Hirotoshi ; Ishihara, Kiyoshi ; Nishimura, Tsunehiko</creator><creatorcontrib>Kubota, Takao ; Yamada, Kei ; Kizu, Osamu ; Hirota, Tatsuya ; Ito, Hirotoshi ; Ishihara, Kiyoshi ; Nishimura, Tsunehiko</creatorcontrib><description>Purpose
To investigate the relationship between the degree of contrast enhancement in fluid‐attenuated inversion recovery (FLAIR) sequences and tumor signal intensity on T2‐weighted images.
Materials and Methods
A total of 96 patients suspected of having brain tumors were examined by MR imaging, and whenever a brain tumor with an enhancing part larger than the slice thickness was demonstrated on postcontrast T1‐weighted images, postcontrast FLAIR images were additionally acquired. The tumor signal intensity on the T2‐weighted images was visually classified as follows: equal or lower compared with normal cerebral cortex (group 1), higher than normal cortex (group 2), and as high as cerebrospinal fluid (CSF) (group 3). When a lesion contained several parts with different signal intensities on T2‐weighted images, we assessed each part separately. In each group, we visually compared pre‐ and postcontrast FLAIR images and assessed whether tumor contrast enhancement was present. When contrast enhancement was present on FLAIR sequence, the degree of contrast enhancement in T1‐weighted and FLAIR sequences was visually compared.
Results
Postcontrast T1‐weighted images showed 46 enhancing lesions, including 48 parts, in 31 MR examinations. FLAIR images of the lesion‐parts in group 1 (N = 18) did not show significant contrast enhancement. In group 2 (N = 12), all the parts were enhanced in FLAIR sequences, and three parts were enhanced more clearly in the FLAIR sequences than in the T1‐weighted sequences. In group 3 (N = 18), all the parts were enhanced equally or more clearly in the FLAIR sequences than in the T1‐weighted sequences.
Conclusion
The signal intensity in FLAIR sequences is largely influenced by both T1 and T2 relaxation time; there is a close relationship between the signal intensity of brain tumors on T2‐weighted images and the degree of contrast enhancement on FLAIR sequences. When tumors have higher signal intensity than normal cortex on T2‐weighted images, additional postcontrast FLAIR imaging may improve their depiction. J. Magn. Reson. Imaging 2005;21:694–700. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.20331</identifier><identifier>PMID: 15906343</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenoma - diagnosis ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Astrocytoma - diagnosis ; Brain Neoplasms - diagnosis ; brain tumor ; contrast enhancement ; Contrast Media ; Female ; FLAIR ; Gadolinium DTPA ; Humans ; Image Enhancement - methods ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; MR imaging ; T2 relaxation time</subject><ispartof>Journal of magnetic resonance imaging, 2005-06, Vol.21 (6), p.694-700</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>Copyright (c) 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4321-76a12db143ab44b38a956170987ebe50621246e841ac8f7b0a3f9e8da9b2a6a23</citedby><cites>FETCH-LOGICAL-c4321-76a12db143ab44b38a956170987ebe50621246e841ac8f7b0a3f9e8da9b2a6a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.20331$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.20331$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15906343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubota, Takao</creatorcontrib><creatorcontrib>Yamada, Kei</creatorcontrib><creatorcontrib>Kizu, Osamu</creatorcontrib><creatorcontrib>Hirota, Tatsuya</creatorcontrib><creatorcontrib>Ito, Hirotoshi</creatorcontrib><creatorcontrib>Ishihara, Kiyoshi</creatorcontrib><creatorcontrib>Nishimura, Tsunehiko</creatorcontrib><title>Relationship between contrast enhancement on fluid-attenuated inversion recovery MR sequences and signal intensity on T2-weighted MR images: Visual evaluation of brain tumors</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To investigate the relationship between the degree of contrast enhancement in fluid‐attenuated inversion recovery (FLAIR) sequences and tumor signal intensity on T2‐weighted images.
Materials and Methods
A total of 96 patients suspected of having brain tumors were examined by MR imaging, and whenever a brain tumor with an enhancing part larger than the slice thickness was demonstrated on postcontrast T1‐weighted images, postcontrast FLAIR images were additionally acquired. The tumor signal intensity on the T2‐weighted images was visually classified as follows: equal or lower compared with normal cerebral cortex (group 1), higher than normal cortex (group 2), and as high as cerebrospinal fluid (CSF) (group 3). When a lesion contained several parts with different signal intensities on T2‐weighted images, we assessed each part separately. In each group, we visually compared pre‐ and postcontrast FLAIR images and assessed whether tumor contrast enhancement was present. When contrast enhancement was present on FLAIR sequence, the degree of contrast enhancement in T1‐weighted and FLAIR sequences was visually compared.
Results
Postcontrast T1‐weighted images showed 46 enhancing lesions, including 48 parts, in 31 MR examinations. FLAIR images of the lesion‐parts in group 1 (N = 18) did not show significant contrast enhancement. In group 2 (N = 12), all the parts were enhanced in FLAIR sequences, and three parts were enhanced more clearly in the FLAIR sequences than in the T1‐weighted sequences. In group 3 (N = 18), all the parts were enhanced equally or more clearly in the FLAIR sequences than in the T1‐weighted sequences.
Conclusion
The signal intensity in FLAIR sequences is largely influenced by both T1 and T2 relaxation time; there is a close relationship between the signal intensity of brain tumors on T2‐weighted images and the degree of contrast enhancement on FLAIR sequences. When tumors have higher signal intensity than normal cortex on T2‐weighted images, additional postcontrast FLAIR imaging may improve their depiction. J. Magn. Reson. Imaging 2005;21:694–700. © 2005 Wiley‐Liss, Inc.</description><subject>Adenoma - diagnosis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Astrocytoma - diagnosis</subject><subject>Brain Neoplasms - diagnosis</subject><subject>brain tumor</subject><subject>contrast enhancement</subject><subject>Contrast Media</subject><subject>Female</subject><subject>FLAIR</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MR imaging</subject><subject>T2 relaxation time</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu00AUhi0Eojc2PACaFQskl7l5bLNDFfSiNEhpAInN6Ng-TqbY4zAzbpqX4hmZNAF27WrO4vt-za8_SV4zesoo5e9ve2dOORWCPUsOWcZ5yrNCPY83zUTKCpofJEfe31JKy1JmL5MDlpVUCSkOk98z7CCYwfqlWZEKwxrRknqwwYEPBO0SbI092kAGS9puNE0KIaAdIWBDjL1D56NOHNZDvDfkekY8_hoxap6AbYg3CwtdRKPlTdhsg-Y8XaNZLLcZUTA9LNB_IN-MHyOKd9CND78iQ0sqB8aSMPaD8yfJixY6j6_273Hy9fOn-dlFOvlyfnn2cZLWUnCW5goYbyomBVRSVqKAMlMsp2WRY4UZVZxxqbCQDOqizSsKoi2xaKCsOCjg4jh5u8tduSF28UH3xtfYdWBxGL1WeaEKlZVPgqyUjFNJI_huB9Zu8N5hq1cu1nYbzajezqi3M-qHGSP8Zp86Vj02_9H9bhFgO2BtOtw8EqWvrmeXf0PTnWN8wPt_DrifsY7IM_19eq5vLqZX0x-TuabiD3qXuzM</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Kubota, Takao</creator><creator>Yamada, Kei</creator><creator>Kizu, Osamu</creator><creator>Hirota, Tatsuya</creator><creator>Ito, Hirotoshi</creator><creator>Ishihara, Kiyoshi</creator><creator>Nishimura, Tsunehiko</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Relationship between contrast enhancement on fluid-attenuated inversion recovery MR sequences and signal intensity on T2-weighted MR images: Visual evaluation of brain tumors</title><author>Kubota, Takao ; Yamada, Kei ; Kizu, Osamu ; Hirota, Tatsuya ; Ito, Hirotoshi ; Ishihara, Kiyoshi ; Nishimura, Tsunehiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4321-76a12db143ab44b38a956170987ebe50621246e841ac8f7b0a3f9e8da9b2a6a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenoma - diagnosis</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Astrocytoma - diagnosis</topic><topic>Brain Neoplasms - diagnosis</topic><topic>brain tumor</topic><topic>contrast enhancement</topic><topic>Contrast Media</topic><topic>Female</topic><topic>FLAIR</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MR imaging</topic><topic>T2 relaxation time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubota, Takao</creatorcontrib><creatorcontrib>Yamada, Kei</creatorcontrib><creatorcontrib>Kizu, Osamu</creatorcontrib><creatorcontrib>Hirota, Tatsuya</creatorcontrib><creatorcontrib>Ito, Hirotoshi</creatorcontrib><creatorcontrib>Ishihara, Kiyoshi</creatorcontrib><creatorcontrib>Nishimura, Tsunehiko</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubota, Takao</au><au>Yamada, Kei</au><au>Kizu, Osamu</au><au>Hirota, Tatsuya</au><au>Ito, Hirotoshi</au><au>Ishihara, Kiyoshi</au><au>Nishimura, Tsunehiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between contrast enhancement on fluid-attenuated inversion recovery MR sequences and signal intensity on T2-weighted MR images: Visual evaluation of brain tumors</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2005-06</date><risdate>2005</risdate><volume>21</volume><issue>6</issue><spage>694</spage><epage>700</epage><pages>694-700</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To investigate the relationship between the degree of contrast enhancement in fluid‐attenuated inversion recovery (FLAIR) sequences and tumor signal intensity on T2‐weighted images.
Materials and Methods
A total of 96 patients suspected of having brain tumors were examined by MR imaging, and whenever a brain tumor with an enhancing part larger than the slice thickness was demonstrated on postcontrast T1‐weighted images, postcontrast FLAIR images were additionally acquired. The tumor signal intensity on the T2‐weighted images was visually classified as follows: equal or lower compared with normal cerebral cortex (group 1), higher than normal cortex (group 2), and as high as cerebrospinal fluid (CSF) (group 3). When a lesion contained several parts with different signal intensities on T2‐weighted images, we assessed each part separately. In each group, we visually compared pre‐ and postcontrast FLAIR images and assessed whether tumor contrast enhancement was present. When contrast enhancement was present on FLAIR sequence, the degree of contrast enhancement in T1‐weighted and FLAIR sequences was visually compared.
Results
Postcontrast T1‐weighted images showed 46 enhancing lesions, including 48 parts, in 31 MR examinations. FLAIR images of the lesion‐parts in group 1 (N = 18) did not show significant contrast enhancement. In group 2 (N = 12), all the parts were enhanced in FLAIR sequences, and three parts were enhanced more clearly in the FLAIR sequences than in the T1‐weighted sequences. In group 3 (N = 18), all the parts were enhanced equally or more clearly in the FLAIR sequences than in the T1‐weighted sequences.
Conclusion
The signal intensity in FLAIR sequences is largely influenced by both T1 and T2 relaxation time; there is a close relationship between the signal intensity of brain tumors on T2‐weighted images and the degree of contrast enhancement on FLAIR sequences. When tumors have higher signal intensity than normal cortex on T2‐weighted images, additional postcontrast FLAIR imaging may improve their depiction. J. Magn. Reson. Imaging 2005;21:694–700. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15906343</pmid><doi>10.1002/jmri.20331</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma - diagnosis Adolescent Adult Aged Aged, 80 and over Astrocytoma - diagnosis Brain Neoplasms - diagnosis brain tumor contrast enhancement Contrast Media Female FLAIR Gadolinium DTPA Humans Image Enhancement - methods Magnetic Resonance Imaging - methods Male Middle Aged MR imaging T2 relaxation time |
| title | Relationship between contrast enhancement on fluid-attenuated inversion recovery MR sequences and signal intensity on T2-weighted MR images: Visual evaluation of brain tumors |
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