Macrophage activation by polysaccharide isolated from Astragalus membranaceus

We show that APS, a polysaccharide isolated from the roots of Astragalus membranaceus, significantly induces nitric oxide (NO) production and inducible NO synthase (iNOS) transcription through the activation of nuclear factor-κB/Rel (NF-κB/Rel). In vivo administration of APS induced NO production by...

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Veröffentlicht in:	International immunopharmacology 2005-07, Vol.5 (7), p.1225-1233
Hauptverfasser:	Lee, Kun Yeong, Jeon, Young Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals Astragalus membranaceus Astragalus membranaceus - chemistry Biological and medical sciences Cell Line Female Gene Expression Regulation, Enzymologic - drug effects iNOS Macrophage Activation - drug effects Macrophages Medical sciences Mice NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB/Rel Nitric Oxide - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Nitrites - metabolism Pharmacology. Drug treatments Polymyxin B - pharmacology Polysaccharides - pharmacology
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