HMG-CoA reductase inhibitors improve acute ischemic stroke outcome
Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of...
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| Veröffentlicht in: | Stroke (1970) 2005-06, Vol.36 (6), p.1298-1300 |
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| container_title | Stroke (1970) |
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| creator | MOONIS, Majaz KANE, Kevin SCHWIDERSKI, Ute SANDAGE, Bobby W FISHER, Marc |
| description | Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored.
We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score < or =2 at 12 weeks and modified Rankin Scale (mRS) < or =2.
Before stroke, 129 patients were receiving statins, 123 initiated statins within 4 weeks, and 600 patients were not on statins. Multivariate logistic regression analysis demonstrated that poststroke statins were associated with a significant probability of a favorable outcome at 12 weeks [NIHSS (P=0.002; OR, 1.92; CI, 1.27 to 2.91) and mRS (P=0.033; OR, 1.57; CI, 1.04 to 2.38)], whereas prestroke statins demonstrated a trend toward significance.
These preliminary results suggest that statin use may improve outcome of acute ischemic stroke. |
| doi_str_mv | 10.1161/01.str.0000165920.67784.58 |
| format | Article |
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We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score < or =2 at 12 weeks and modified Rankin Scale (mRS) < or =2.
Before stroke, 129 patients were receiving statins, 123 initiated statins within 4 weeks, and 600 patients were not on statins. Multivariate logistic regression analysis demonstrated that poststroke statins were associated with a significant probability of a favorable outcome at 12 weeks [NIHSS (P=0.002; OR, 1.92; CI, 1.27 to 2.91) and mRS (P=0.033; OR, 1.57; CI, 1.04 to 2.38)], whereas prestroke statins demonstrated a trend toward significance.
These preliminary results suggest that statin use may improve outcome of acute ischemic stroke.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.str.0000165920.67784.58</identifier><identifier>PMID: 15879346</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain Ischemia - drug therapy ; Cerebral Hemorrhage - drug therapy ; Cerebrovascular Disorders - drug therapy ; Female ; Follow-Up Studies ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Nervous system (semeiology, syndromes) ; Neurology ; Odds Ratio ; Pharmacology. Drug treatments ; Recurrence ; Regression Analysis ; Risk ; Severity of Illness Index ; Stroke - drug therapy ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2005-06, Vol.36 (6), p.1298-1300</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-52cf047dd6aa79606c0cf829de5181809d525b326e7adbe74495535b934526373</citedby><cites>FETCH-LOGICAL-c532t-52cf047dd6aa79606c0cf829de5181809d525b326e7adbe74495535b934526373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3685,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16820955$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15879346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOONIS, Majaz</creatorcontrib><creatorcontrib>KANE, Kevin</creatorcontrib><creatorcontrib>SCHWIDERSKI, Ute</creatorcontrib><creatorcontrib>SANDAGE, Bobby W</creatorcontrib><creatorcontrib>FISHER, Marc</creatorcontrib><title>HMG-CoA reductase inhibitors improve acute ischemic stroke outcome</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored.
We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score < or =2 at 12 weeks and modified Rankin Scale (mRS) < or =2.
Before stroke, 129 patients were receiving statins, 123 initiated statins within 4 weeks, and 600 patients were not on statins. Multivariate logistic regression analysis demonstrated that poststroke statins were associated with a significant probability of a favorable outcome at 12 weeks [NIHSS (P=0.002; OR, 1.92; CI, 1.27 to 2.91) and mRS (P=0.033; OR, 1.57; CI, 1.04 to 2.38)], whereas prestroke statins demonstrated a trend toward significance.
These preliminary results suggest that statin use may improve outcome of acute ischemic stroke.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain Ischemia - drug therapy</subject><subject>Cerebral Hemorrhage - drug therapy</subject><subject>Cerebrovascular Disorders - drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Pharmacology. Drug treatments</subject><subject>Recurrence</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>Severity of Illness Index</subject><subject>Stroke - drug therapy</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-BQmC3hL3-8NbLdoKFUHredlsNjSaNHU3Efz3bm2gR-eyh3lm5t0HgCsEM4Q4uoUoC53PYCzEmcIw40JImjF5BMaIYZpSjuUxGENIVIqpUiNwFsJH5DGR7BSMEJNCEcrH4H7xPE9n7TTxruhtZ4JLqs26yquu9SGpmq1vv11ibN_FRrBr11Q2idfbT5e0fWfbxp2Dk9LUwV0M7wS8Pz6sZot0-TJ_mk2XqWUEdynDtoRUFAU3RigOuYW2lFgVjiGJJFQFwywnmDthitwJShVjhOUxJ8OcCDIBN_u9MdNX70Knm5jI1bXZuLYPmgvJJRH8XxApEf3E5RNwtwetb0PwrtRbXzXG_2gE9U61hki_rV71QbX-U62ZjMOXw5U-b1xxGB3cRuB6AEywpi692dgqHDguMdx98RcSRoZi</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>MOONIS, Majaz</creator><creator>KANE, Kevin</creator><creator>SCHWIDERSKI, Ute</creator><creator>SANDAGE, Bobby W</creator><creator>FISHER, Marc</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>HMG-CoA reductase inhibitors improve acute ischemic stroke outcome</title><author>MOONIS, Majaz ; KANE, Kevin ; SCHWIDERSKI, Ute ; SANDAGE, Bobby W ; FISHER, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-52cf047dd6aa79606c0cf829de5181809d525b326e7adbe74495535b934526373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain Ischemia - drug therapy</topic><topic>Cerebral Hemorrhage - drug therapy</topic><topic>Cerebrovascular Disorders - drug therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Pharmacology. Drug treatments</topic><topic>Recurrence</topic><topic>Regression Analysis</topic><topic>Risk</topic><topic>Severity of Illness Index</topic><topic>Stroke - drug therapy</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOONIS, Majaz</creatorcontrib><creatorcontrib>KANE, Kevin</creatorcontrib><creatorcontrib>SCHWIDERSKI, Ute</creatorcontrib><creatorcontrib>SANDAGE, Bobby W</creatorcontrib><creatorcontrib>FISHER, Marc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOONIS, Majaz</au><au>KANE, Kevin</au><au>SCHWIDERSKI, Ute</au><au>SANDAGE, Bobby W</au><au>FISHER, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HMG-CoA reductase inhibitors improve acute ischemic stroke outcome</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>36</volume><issue>6</issue><spage>1298</spage><epage>1300</epage><pages>1298-1300</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored.
We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score < or =2 at 12 weeks and modified Rankin Scale (mRS) < or =2.
Before stroke, 129 patients were receiving statins, 123 initiated statins within 4 weeks, and 600 patients were not on statins. Multivariate logistic regression analysis demonstrated that poststroke statins were associated with a significant probability of a favorable outcome at 12 weeks [NIHSS (P=0.002; OR, 1.92; CI, 1.27 to 2.91) and mRS (P=0.033; OR, 1.57; CI, 1.04 to 2.38)], whereas prestroke statins demonstrated a trend toward significance.
These preliminary results suggest that statin use may improve outcome of acute ischemic stroke.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15879346</pmid><doi>10.1161/01.str.0000165920.67784.58</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain Ischemia - drug therapy Cerebral Hemorrhage - drug therapy Cerebrovascular Disorders - drug therapy Female Follow-Up Studies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Medical sciences Middle Aged Multivariate Analysis Nervous system (semeiology, syndromes) Neurology Odds Ratio Pharmacology. Drug treatments Recurrence Regression Analysis Risk Severity of Illness Index Stroke - drug therapy Treatment Outcome Vascular diseases and vascular malformations of the nervous system |
| title | HMG-CoA reductase inhibitors improve acute ischemic stroke outcome |
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